For the most updated list of publications from this group, please visit this site.
Journals
D.R. Dautel, J.A. Champion. “Self-Assembly of Functional Protein Nanosheets from Thermo-responsive Bolaamphiphiles.” Biomacromolecules. 2022. Accepted.
D.R. Dautel, W.T. Heller, J.A. Champion. “Protein Vesicles with pH Responsive Disassembly.” Biomacromolecules. 2022. In press.
Y. Li, J.A. Champion. “Self-assembling Nanocarriers from Engineered Proteins: Design, Functionalization, and Application for Drug Delivery.” Advanced Drug Delivery Reviews. 114462. 2022. (invited)
Photocrosslinked, Tunable Protein Vesicles for Drug Delivery Applications.” Adv Healthc Mater. 2021
Demonstration of intracellular trafficking, cytosolic bioavailability, and target manipulation of an antibody delivery platform.” Nanomedicine. 2021
Protein Nanoparticle Charge and Hydrophobicity Govern Protein Corona and Macrophage Uptake.” ACS Appl Mater Interfaces. 2020.
RD Franklin, JA Whitley, AA Caparco, BR Bommarius, JA Champion, AS Bommarius. “Continuous production of a chiral amine in a packed bed reactor with co-immobilized amine dehydrogenase and formate dehydrogenase.” Chemical Engineering Journal. 2020.
DR Dautel, JA Champion. “Protein Vesicles Self-Assembled from Functional Globular Proteins with Different Charge and Size.” Biomacromolecules. 2020.
AN Tsoras, KM Wong, AK Paravastu, JA Champion. “Rational Design of Antigen Incorporation Into Subunit Vaccine Biomaterials Can Enhance Antigen-Specific Immune Responses.” Frontiers in Immunology. 2020.
KM Poulsen, T Pho, JA Champion, CK Payne. “Automation and low-cost proteomics for characterization of the protein corona: experimental methods for big data.” Analytical and Bioanalytical Chemistry. 2020.
Protein and Peptide Nanocluster Vaccines.” Curr Top Microbiol Immunol. 2020
Caparco AA, Pelletier E, Petit, JL, Jouenne A, Bommarius BR, Berardinis V, Zaparucha A, Champion JA, Bommarius AS, Vergne-Vaxelaire C. “Metagenomic Mining for Amine Dehydrogenase Discovery.” Advanced Synthesis & Catalysis. 2020; 362:1-11.
Caparco AA, Bommarius BR, Bommarius AS, Champion JA. “Protein‐inorganic calcium‐phosphate supraparticles as a robust platform for enzyme co‐immobilization.” Biotechnology and Bioengineering. 2020; 1-11.
Tuning the Morphology of Protein-Inorganic Calcium-Phosphate Supraparticles via Directed Assembly. Langmuir. 2020
Dhankher A, Hernandez ME, Howard HC, Champion JA. “Characterization and Control of Dynamic Rearrangement in a Self-Assembled Antibody Carrier.” Biomacromolecules. 2020; 21(4):1407-1416.
Understanding the Coacervate-to-Vesicle Transition of Globular Fusion Proteins to Engineer Protein Vesicle Size and Membrane Heterogeneity.” Biomacromolecules. 2019; 20(9):3494-3503.
Tsoras AN, Champion JA. “Protein and Peptide Biomaterials for Engineered Subunit Vaccines and Immunotherapeutic Applications.” Annual Review of Chemical and Biomolecular Engineering. 2019; 10:337-359.
Ling K, Wu H, Neish AS, Champion JA. “Alginate/chitosan microparticles for gastric passage and intestinal release of therapeutic protein nanoparticles.” Journal of Controlled Release. 2019; 295:174-186.
Garapaty A, Champion JA. “Shape of ligand immobilized particles dominates and amplifies the macrophage cytokine response to ligands.” PloS one. 2019; 14(5).
Rosu C, Jang Y, Jiang L, Champion JA. “Nature-Inspired and “Water-Skating” Paper and Polyester Substrates Enabled by the Molecular Structure of Poly(γ-stearyl-α,l-glutamate) Homopolypeptide.” Biomacromolecules. 2018; 19(12):4617-4628.
Wilson CJ, Bommarius AS, Champion JA, Chernoff YO, Lynn DG, Paravastu AK, Liang C, Hsieh MC, Heemstra JM. “Biomolecular assemblies: moving from observation to predictive design.” Chemical Reviews. 2018; 118(24):11519-11574.
Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsuyama S, Yu G, Compans RW, Li JD, Prausnitz MR, Champion JA, Wang BZ. “Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice.” Proceedings of the National Academy of Sciences. 2018; 115(33):E7758-E7767.
Caparco AA, Bommarius AS, Champion JA. “Effect of peptide linker length and composition on immobilization and catalysis of leucine zipper‐enzyme fusion proteins.” AIChE Journal. 2018; 64(8):2934-2946.
Tsoras AN, Champion JA. “Cross-Linked Peptide Nanoclusters for Delivery of Oncofetal Antigen as a Cancer Vaccine.” Bioconjugate chemistry. 2018;
Deng L, Mohan T, Chang TZ, Gonzalez GX, Wang Y, Kwon YM, Kang SM, Compans RW, Champion JA, Wang BZ. “Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses.” Nature communications. 2018; 9(1):359.
Jang Y, Choi WT, Johnson CT, García AJ, Singh PM, Breedveld V, Hess DW, Champion JA. “Inhibition of Bacterial Adhesion on Nanotextured Stainless Steel 316L by Electrochemical Etching.“ACS biomaterials science & engineering. 2018; 4(1):90-97.
Chang TC, Deng L, Wang BZ, Champion JA. “H7 Hemagglutinin nanoparticles retain immunogenicity after> 3 months of 25 C storage.” PloS one. 2018; 13(8).
Herrera Estrada L, Wu H, Ling K, Zhang G, Sumagin R, Parkos CA, Jones RM, Champion JA, Neish AS. “Bioengineering Bacterially Derived Immunomodulants: A Therapeutic Approach to Inflammatory Bowel Disease.” ACS nano. 2017; 11(10):9650-9662.
Jang Y, Choi WT, Heller WT, Ke Z, Wright ER, Champion JA. “Engineering Globular Protein Vesicles through Tunable Self-Assembly of Recombinant Fusion Proteins.” Small (Weinheim an der Bergstrasse, Germany). 2017; 13(36).
Deng L, Kim JR, Chang TZ, Zhang H, Mohan T, Champion JA, Wang BZ. “Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge.” Virology. 2017; 509:82-89.
Lim SI, Lukianov CI, Champion JA.”Self-assembled protein nanocarrier for intracellular delivery of antibody.” J. of Controlled Release. (2017) 249:1-10.
Chang TZ, Diambou I, Kim JR, Wang B, Champion JA. “Host- and pathogen-derived adjuvant coatings on protein nanoparticle vaccines.” Bioeng Transl Med. (2017) 2(1):120-130.
Garapaty A, Champion JA. “Tunable particles alter macrophage uptake based on combinatorial effects of physical properties.” Bioengineering & Translational Medicine. (2017) 2(1): 92-101
Padmore T, Stark C, Turkevich LA, Champion JA. “Quantitative analysis of the role of fiber length on phagocytosis and inflammatory response by alveolar macrophages.” Biochimica et biophysica acta. (2017) 1861(2):58-67.
Chang TZ, Stadmiller SS, Staskevicius E, Champion JA. “Effects of ovalbumin protein nanoparticle vaccine size and coating on dendritic cell processing.” Biomaterials science. (2017) 5(2):223-233.
Park W, Yee CM, Champion JA. “Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α.” Journal of Materials Chemistry B. (2016) 4(9):1633-9.
Jang Y, Champion JA. “Self-Assembled Materials Made from Functional Recombinant Proteins.” Accounts of chemical research. (2016); 49(10): 2188-2198. PubMed PMID: 27677734
Park WM, Champion JA. “Colloidal Assembly of Hierarchically Structured Porous Supraparticles from Flower-Shaped Protein-Inorganic Hybrid Nanoparticles.” ACS nano. (2016); 10(9):8271-80. PubMed PMID: 27552189
Wang L, Chang TZ, He Y, Kim JR, Wang S, Mohan T, Berman Z, Tompkins SM, Tripp RA, Compans RW, Champion JA, Wang BZ. “Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity.” Nanomedicine : nanotechnology, biology, and medicine. (2016). PubMed PMID: 27622321
Herrera Estrada LP, Padmore TJ, Champion JA. “Bacterial Effector Nanoparticles as Breast Cancer Therapeutics.” Mol. Pharmaceutics. (2016) DOI: 10.1021/acs.molpharmaceut.5b0037
Park WM, Yee CM, Champion JA. “Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α.” J Mater Chem B. 2016. DOI:10.1039/C5TB01647A
Garapaty A, Champion JA. “Non-covalent phosphorylcholine coating reduces protein adsorption and phagocytic uptake of microparticles.” Chem Commun. 2015. DOI:10.1039/C5CC03459K.
Garapaty, A. and J. A. Champion (2015). “Biomimetic and synthetic interfaces to tune immune responses.” Biointerphases 10(3): 030801.
Zan X, Garapaty A, Champion JA. “Engineering Polyelectrolyte Capsules with Independently Controlled Size and Shape.” Langmuir. 2015.
Herrera Estrada LP, Champion JA. “Protein nanoparticles for therapeutic protein delivery.” Biomaterials Science. 2015;3(6):787-799.
Tiernan, A. R., J. A. Champion, et al. (2015). “Trichostatin A affects the secretion pathways of beta and intestinal endocrine cells.” Experimental Cell Research 330(1): 212-221.
Park, W. M. and J. A. Champion (2014). “Thermally Triggered Self-Assembly of Folded Proteins into Vesicles.” Journal of the American Chemical Society.
Silverman, B. R. and J. A. Champion (2014). “Presentation of fibronectin fragments using affinity protein interactions for enhanced retention and function.” Acta Biomaterialia 10(12): 4956-4960
Estrada, L. H., S. Chu, et al. (2014). “Protein Nanoparticles for Intracellular Delivery of Therapeutic Enzymes.” Journal of Pharmaceutical Sciences 103(6): 1863-1871
Wang L, Hess A, Chang TZ, Wang YC, Champion JA, Compans RW, Wang BZ. “Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines.” Nanomedicine: Nanotechnology, Biology and Medicine 10(2): 473-482
W.M. Park and J.A. Champion. “Two-Step Protein Self-Assembly in the Extracellular Matrix.” Angew. Chem. Int. Ed.(2013) 52.31, 8098-8101.
J.T. Ngo, B.M. Babin, J.A. Champion, E.M. Shuman and D.A. Tirrell. “State-selective metabolic labeling of cellular proteins.” ACS Chem. Biol .(2012) 7.8, 1326-1330. (commentary C&E News online, 2012.)
J.A. Champion and S. Mitragotri. “Role of target geometry in phagocytosis.” PNAS. 103(13), 4930-4934. 2006. (PNAScover image by JAC, commentary J. Cell Biol. 173(1), 2006.)
J.A. Champion, Y.K. Katare and S. Mitragotri. “Particle shape: A new design parameter for micro and nanoscale drug delivery carriers.” J. Control. Release. 121(1), 3-9. 2007.
J.A. Champion, Y.K. Katare and S. Mitragotri. “Making polymeric micro- and nanoparticles of complex shapes.” PNAS.104(29), 11901-11904. 2007. (commentary Science 317(5838), 2007 and C&E News 85(29), 2007.)
J.A. Champion, A. Walker and S. Mitragotri. “Role of particle size in phagocytosis of polymeric microspheres.” Pharm. Res. 25(8), 1815-1821. 2008.
S. Muro, C. Garnacho, J.A. Champion, J. Leferovich, C. Gajewski, E. Schuchman, S. Mitragotri and V.R. Muzykantov. “Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.” Mol. Ther. 16(8), 1450-1458. 2008.
J.A. Champion and S. Mitragotri. “Shape induced inhibition of phagocytosis of polymer particles.” Pharm. Res. 26(1), 244-249. 2009.
J.T. Ngo, J.A. Champion, A. Mahdavi, I.C. Tanrikulu, K.E. Beatty, R.E. Connor, T.H. Yoo, D.C. Dieterich, E.M. Shuman and D.A. Tirrell. “Cell-selective metabolic labeling of proteins.” Nat. Chem. Biol. 5(10), 715-717. 2009. (Nat. Chem. Biol. cover image by JAC, commentary Nature 460(805), 2009.)
Chapters
J.A. Champion and S. Mitragotri. “Ch 15: UFOs, worms, and surfboards: What shapes teach us about cell-material interactions.” Advances in Regenerative Medicine: Role of Nanotechnology and Engineering Principles. V.P. Shastri et al. (eds). Springer. 2010.
Patent Applications
J.A. Champion, T.C. Chang. “Antibody-coated nanoparticle vaccines.” Filed 2019.
J.A. Champion, S.I. Lim. “Nanocarriers for Intracellular Delivery.” Filed 2019.
A.S. Neish, J.A. Champion. “Protein particles comprising disulfide crosslinkers and uses.” Filed 2018.
J.A. Champion, W.M. Park. “Protein vesicles and methods of making and using thereof.” Filed 2016.
J.A. Champion, S. Mitragotri and Ahmet Tezel. “Swellable hyaluronic acid particles.” Filed 2010.
J.A. Champion and S. Mitragotri. “Coated hyaluronic acid particles.” Filed 2008.
J.A. Champion, Y.K. Katare and S. Mitragotri. “Engineering shape of polymeric micro- and nanoparticles.” Filed 2007.