Finn Research Group

the Finn Group's people, science, and history

Nobel 2022 Celebration!

In 2022, K. Barry Sharpless was awarded his second Nobel Prize, this one for click chemistry! Our group members at Scripps and Georgia Tech have done much to highlight the power of this idea and enable its implementation in different fields. We are so happy and grateful to have had this opportunity, and we join the world of molecular science to congratulate Barry, Carolyn Bertozzi, and Morten Meldal.

Below are some of the key click-related papers from our group over the years

K. Barry Sharpless’s 2022 Nobel Lecture: “Click Chemistry: the Certainty of Chance”

M.G. Finn’s Georgia Tech lecture: “The 2022 Nobel Prize in Chemistry: Click and Bioorthogonal Chemistry from a Click OG”

Angew. Chem. Int. Ed.
(2014)

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry (2014)

Angew. Chem. Int. Ed.
(2009)

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

Angew. Chem. Int. Ed.
(2005)

first study of the CuAAC mechanism: “Mechanism of the Ligand-Free Cu(I)-Catalyzed Azide-Alkyne Cycloaddition ReactioN”

Angew. Chem. Int. Ed.
(2005)

“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension

J. Polym. Sci. A: Polym. Chem.
(2004)

FIRST use of CuAAC to make polymers. “Click chemistry in materials synthesis. 1. Adhesive polymers from copper-catalyzed azide-alkyne cycloaddition”

J. Am. Chem. Soc.
(2004)

FIRST use of CuAAC for bioconjugation: “Bioconjugation by copper(I)-catalyzed azide-alkyne cycloaddition”

Angew. Chem. Int. Ed.
(2002)

Click Chemistry in situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks

Angew. Chem. Int. Ed.
(2001)

The Manifesto: “Click Chemistry: Diverse Chemical Function from a Few Good Reactions”