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Head Injury Publications

• Oeur A, Torp WH, Arbogast KB, Master CL, Margulies SS. Altered Auditory and Visual Evoked Potentials following Single and Repeated Low-Velocity Head Rotations in 4-Week-Old Swine. Biomedicines. 2023; 11(7):1816. https://doi.org/10.3390/biomedicines11071816
• Oeur A, Mull M, Riccobono G, Arbogast KB, Ciuffreda KJ, Joshi N, Fedonni D, Master CL, Margulies SS. Pupillary Light Response Deficits in 4-Week-Old Piglets and Adolescent Children after Low-Velocity Head Rotations and Sports-Related Concussions. Biomedicines. 2023; 11(2):587. https://doi.org/10.3390/biomedicines11020587
• Oeur RA, Palaniswamy M, Ha M, Fernández Corazza M, Margulies SS. Regional variations distinguish auditory from visual evoked potentials in healthy 4-week old piglets. Physiological Measurement. Jan 2023. doi: 10.1088/1361-6579/acb4da.
• Mull M, Aderibigbe O, Hajiaghamemar M, Oeur RA, Margulies SS. Multiple Head Rotations Result in Persistent Gait Alterations in Piglets. Biomedicines. November 2022; 10(11):2976. https://doi.org/10.3390/biomedicines10112976
• Wu T, Sato F, Antona-Makoshi J, Gabler LF, Giudice JS, Alshareef A, Yaguchi M, Masuda M, Margulies SS, Panzer MB. Integrating Human and Nonhuman Primate Data to Estimate Human Tolerances for Traumatic Brain Injury. J Biomech Eng. Jul 2022;144(7):071003. https://10.1115/1.4053209.
• Wu T, Hajiaghamemar M, Giudice JS, Alshareef A, Margulies SS, Panzer MB. Evaluation of Tissue-Level Brain Injury Metrics Using Species-Specific Simulations. J Neurotrauma. Jun 2021;38(13):1879-1888. https://10.1089/neu.2020.7445.
• Karlsson M, Yang Z, Chawla S, Delso N, Pukenas B, Elmér E, Hugerth M, Margulies SS, Ehinger J, Hansson MJ, Wang KKW, Kilbaugh TJ. Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury. J Neurotrauma. Jun 2021;38(13):1870-1878. https://10.1089/neu.2020.7317.
• Hajiaghamemar M, Margulies SS. Multi-Scale White Matter Tract Embedded Brain Finite Element Model Predicts the Location of Traumatic Diffuse Axonal Injury. J Neurotrauma. 2021 Jan 1;38(1):144-157. https://doi.org/10.1089/neu.2019.6791.
• Oeur A, Margulies SS. Target detection in healthy 4-week old piglets from a passive two-tone auditory oddball paradigm. BCM Neuroscience. December 2020. https://doi.org/10.1186/s12868-020-00601-4
• Pasquesi S, Seidi M, Hajiaghamemar M, Margulies SS. Predictions of neonatal porcine bridging vein rupture and extra-axial hemorrhage during rapid head rotations. Journal of the Mechanical Behavior of Biomedical Materials. June 2020. https://doi.org/10.1016/j.jmbbm.2020.103740.
• Hajiaghamemar M., Seidi M., and Margulies SS. Head Rotational Kinematics, Tissue Deformations, and Their Relationships to the Acute Traumatic Axonal Injury. ASME. J Biomech Eng. March 2020; 142(3): 031006. https://doi.org/10.1115/1.4046393
• Hajiaghamemar M, Kilbaugh T, Arbogast KB, Master CL, Margulies SS. Using Serum Amino Acids to Predict Traumatic Brain Injury: A Systematic Approach to Utilize Multiple Biomarkers. Int J Mol Sci. Mar 2020;21(5):1786. https://doi.org/10.3390/ijms21051786.
• Hajiaghamemar M, Wu T, Panzer MB, Margulies SS. Embedded axonal fiber tracts improve finite element model predictions of traumatic brain injury. Biomech Model Mechanobiol. Jun 2020;19(3):1109-1130. https://10.1007/s10237-019-01273-8.
• Atlan LS, Margulies SS. Frequency-Dependent Changes in Resting State Electroencephalogram Functional Networks after Traumatic Brain Injury in Piglets. J Neurotrauma. Sep 2019;36(17):2558-2578. doi: 10.1089/neu.2017.5574.
• Hajiaghamemar M, Seidi M, Oeur A, Margulies SS. Toward development of clinically translatable diagnostic and prognostic metrics of traumatic brain injury using animal models: A review and a look forward. Experimental Neurology. August 2019. https://doi.org/10.1016/j.expneurol.2019.04.019
• Smith AM, Alford PA, Aubry M, Bensen B, Black A, Brooks A, Burke C, D’Arcy R, Dodick D, Eaves M, Eickhoff C, Erredge K, Farrell K, Finnoff J, Fraser D, Giza C, Greenwald RM, Hanzel M, Hoshizaki B, Huston J, Jorgenson J, Joyner M, Krause D, LaVoi N, Leaf M, Leddy J, Leopold J, Margarucci K, Margulies SS, Mihalik J, Munce T, Oeur A, Podein S, Prideaux C, Roberts W, Shen F, Soma D, Tabrum M, Stuart MB, Wethe J, Whitehead J, Wiese-Bjornstal D, and Stuart MJ. Ice Hockey Summit III Proceedings: Action on Concussion. Current Sports Medicine Reports (2019) Jan 18(1):23-34. doi: 10.1249/JSR.0000000000000557. PMID: 30624332.
• Hajiaghamemar M, Lan IS, Christian CW; Coats B, Margulies SS. Infant skull fracture risk for low height falls. International Journal of Legal Medicine (2019); 133(3): 847-862. https://doi.org/10.1007/s00414-018-1918-1.
• Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmer E, Hansson MJ, Margulies SS, Kilbaugh T. Neuroprotective Effects of Cyclosporine in a Porcine Pre-Clinical Trial of Focal Traumatic Brain Injury. J. Neurotrauma. 2018 Jul 24. doi: 10.1089/neu.2018.5706. PMID: 29929438, PMCID: PMC6306685.
• Atlan LA, Lan IS, Smith C, Margulies SS. Changes in Event-Related Functional Networks Predict Traumatic Brain Injury in Piglets. Clinical Biomechanics, special issue on Central Nervous System Injury. 2019 Apr;64:14-21. PMID: 29933967, PMCID: PMC6274597.
• Pasquesi S, Margulies SS. Measurement and Finite Element Model Validation of Immature Porcine Brain-Skull Displacement During Rapid Head Rotations. Frontiers in Bioengineering and Biotechnology – Biomechanics. 2018 Feb 21;6:16. PMID: 2951599, PMCID: PMC5826385.
• Atlan L, Smith C, Margulies SS. Improved Prediction of Direction-Dependent, Acute Axonal Injury in Female Piglets. Neurosci Res., special issue on Traumatic Brain Injury Research. 2018 Apr;96(4):536-544. PMID: 28833411.
• Pasquesi S, Margulies SS. Failure and Fatigue Properties of Immature Human and Porcine Parasagittal Bridging Veins. Ann Biomed Eng. 2017 Aug; 45(8): 1877-1889. doi: 10.1007/s10439-017-1833-5. PMID: 28405773, PMCID: PMC5529232.
• Coats B, Binebaum G, Smith C, Peiffer RL, Christian CW, Duhaime AC, Margulies SS. Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets. J. Neurotrauma. 2017 Jan 1;34(1):235-247 (Jan 1 2017). doi: 10.1089/neu.2015.4352. PMID: 26953505, PMCID: PMC5198060.
• Kilbaugh T, Karlsson M, Duhaime C, Hansson M, Elmer E, MarguliesSS. Mitochondrial Response In A Toddler-Aged Swine Model Following Diffuse Non-Impact Traumatic Brain Injury. Mitochondrion 26 (2016) 19-25. PMID: 26549476, PMCID: PMC4752861.
• Pasquesi S, Liu Y, Margulies SS. Repeated Loading Behavior of Porcine Common Carotid Arteries. J. Biomech Eng.2016 Dec 1;138(12). PMID: 27306415.
• Cullen D, Harris J, Browne K, Wolf J, Duda J, Meaney D, Margulies SS, Smith D. A Porcine Model of Traumatic Brain Injury Via Head Rotational Acceleration. Methods in Molecular Biology. Methods Mol Biol. 2016;1462:289-324. doi: 10.1007/978-1-4939-3816-2_17. PMID 27604725
• Maltese M, Margulies SS. Biofidelic White Matter Heterogeneity Decreases Computational Model Predictions of White Matter Strains During Rapid Head Rotations. Comput Methods Biomech Biomed Engin. 2016 Nov;19(15):1618-29. PMID: 27123826, PMCID: PMC4996718.
• Scott GG, Margulies SS, Coats B. Utilizing Multiple Scale Models to Improve Predictions of Extra-Axial Hemorrhage in the Immature Piglet. Biomech Model Mechanobiol. 2016 Oct;15(5):1101-19. PMID: 26586144.
• Ferguson MA, Sutton R, Karlsson M, Sjovall F, Becker L, Berg R, Margulies SS, Kilbaugh, TJ. Increased Platelet Mitochondrial Respiration after Cardiac Arrest and Resuscitation as a Potential Peripheral Biosignature of Cerebral Bioenergetic Dysfunction. J. Bioenerg Biomembr. 2016 Jun;48(3):269-79. PMID: 27020568.
• Coats B, Smith C, Binenbaum G, Pfeiffer RL, Christian C, Duhaime AC, Margulies SS. Cyclic Head Rotations Produce Modest Brain Injury in Infant Piglets. J. Neurotrauma. 2016 May 11 [epub ahead of print]. PMID: 26953505.
• Olson E*, Badder C*, Sullivan S, Propert K, Margulies SS. Alterations in Daytime and Nighttime Activity in Piglets after Focal and Diffuse Brain Injury. Neurotrauma. 2016 Apr 15;33(8):734-40. PMID: 26414329, PMCID: PMC4841073.
• Margulies SS. Emerging Insight from Human and Animal Studies about the Biomechanics of Concussion. The Bridge. Spring 2016; 46 (1).
• Margulies SS, Anderson G, Fahim A, Badaut J, Clark R, Empey P, Guseva M, Hoane M, Huh J, Pauly J, Raghupathi R, Scheff S, Stein D, Tang H, Hicks R. Combination therapies for traumatic brain injury: retrospective considerations. J. Neurotrauma. 2016 Jan 1;33(1):101-12. PMID: 25970337, PMCID: PMC4700397.
• Elliott M, Arbogast K, Maltese M, Margulies SS. Accounting for Sampling Variability, Injury Under-Reporting, and Sensor Error in Concussion Injury Risk Curves. J. Biomechanics. 2015 Sep 18;48(12):3059-65. PMID: 26296855.
• Kilbaugh T, Sutton R, Karlsson M, Hansson M, Naim M, Morgan R, Bratinov G, Lampe J, Nadkarni V, Becker L, Margulies SS, Berg R.Persistently Altered Brain Mitochondrial Bioenergetics after Apparently Successful Resuscitation from Cardiac Arrest. J Am Heart Assoc. 2015 Sep 14;4(9). PMID: 26370446, PMCID: PMC4599507.
• Jaber S, Sullivan S, Hankenson FC, Kilbaugh T, Margulies SS. Comparison of heart rate and blood pressure with toe pinch and bispectral index for monitoring the depth of anesthesia in piglets. J Am Assoc Lab Animal Science. 2015 Sep;54(5):536-44. PMID: 26424252, PMCID: PMC4587622.
• Kilbaugh T, Lvova M, Karlsson M, Zhang Z, Leipzig J, Wallace D, Margulies SS. Peripheral Blood Mitochondrial DNA as a Biomarker of Cerebral Mitochondrial Dysfunction following Traumatic Brain Injury. PLOS One. 2015 Jun 22;10(6):e0130927. PMID: 26098565, PMCID: PMC4476697.
• Sullivan S, Coats B, Margulies SS. Biofidelic neck influences head kinematics of parietal and occipital impacts following short falls in infants.Accident Analysis and Prevention. 2015 Jun 10;82:143-153. PMID: 26072183.
• Kilbaugh T, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime A, Hansson M, Elmer E, Margulies SS. Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Experimental Neurology. 2015 May 28;271:136-144. PMID: 26028309.
• Margulies SS,Kilbaugh T, Sullivan S, Smith C, Propert K, Byro M, Saliga M, Costine BA, Duhaime A-C. Establishing a Clinically Relevant Large Animal Model Platform for TBI Therapy Development: Using Cyclosporin A as a Case Study. Brain Pathology. 2015 May;25(3):289-303. PMID: 25904045, PMCID: PMC4459790.
• Friess S, Bruins B, Kilbaugh T, Smith C, Margulies SS. Differing effects when using phenylephrine and norepinephrine to augment cerebral blood flow after traumatic brain injury in the immature brain. J. Neurotrauma. 2015 Feb 15; 32(4):237-43. PMID: 25072522, PMCID: PMC4321769.
• Jaber S, Sullivan S, Margulies SS. Noninvasive metrics for identification of brain injury deficits in piglets. Developmental Neuropsychology. Dev Neuropsychol. 2015 Jan; 40(1):34-9. PMID: 25649778, PMCID: PMC4318352.
• Clevenger A, Kilbaugh T, Ralston J, Margulies SS. Carotid artery blood flow decreases after rapid head rotation in piglets. J. Neurotrauma. 2015 Jan 15; 32(2):120-6. PMID: 25133889, PMCID: PMC4291216.
• Sullivan S, Eucker SA, Gabrieli D, Bradfield C, Coats B, Maltese MR, Lee J, Smith C, Margulies SS. White matter tract-oriented deformation predicts traumatic axonal brain injury and reveals rotational direction-specific vulnerabilities. Biomechanics and Modeling in Mechanobiology. 2015 Aug;14(4):877-96. PMID: 25547650.
• Weeks D, Sullivan S, Kilbaugh TJ, Smith C, Margulies SS. Influences of developmental age on the resolution of diffuse traumatic intracranial hemorrhage and axonal injury. J Neurotrauma. 2013
• Sullivan S, Friess SH, Ralston J, Smith C, Propert KJ, Rapp PE, Margulies SS. Improved behavior, motor, and cognition assessments in neonatal piglets. J Neurotrauma. 2013
• Bruins B, Kilbaugh TJ, Margulies SS, Friess SH. The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model. Anesth Analg. 2013 Apr;116(4):838-44. Download PDF
• Sullivan S, Friess SH, Ralston J, Smith C, Propert KJ, Rapp PE, Margulies SS. Behavioral deficits and axonal injury persistence following rotational head injury are direction dependent. J Neurotrauma. 2012 Dec 7. Download PDF
• Friess SH, Smith C, Kilbaugh TJ, Frangos SG, Ralston J, Helfaer MA, Margulies SS. Early cerebral perfusion pressure augmentation with phenylephrine after traumatic brain injury may be neuroprotective in a pediatric swine model.Crit Care Med. 2012 Aug;40(8):2400-6. Download PDF
• Coats B, Eucker SA, Sullivan S, Margulies SS. Finite element model predictions of intracranial hemorrhage from non-impact, rapid head rotations in the piglet. Int J Dev Neurosci. 2012 Jan 5. Download PDF
• Friess SH, Naim MY, Kilbaugh TJ, Ralston J, Margulies SS. Premedication with meloxicam exacerbates intracranial haemorrhage in an immature swine model of non-impact inertial head injury. Lab Anim. 2012 Jan 11. Download PDF
• Ibrahim NG, Wood J, Margulies SS, Christian CW. Influence of age and fall type on head injuries in infants and toddlers. Int J Dev Neurosci. 2011 Oct 31. Download PDF
• Friess SH, Ralston J, Eucker SA, Helfaer MA, Smith C, Margulies SS. Neurocritical care monitoring correlates with neuropathology in a swine model of pediatric traumatic brain injury. Neurosurgery. 2011 Nov;69(5):1139-47. Download PDF
• Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosproin A Preserves Mitochondrial Function after Traumatic Brain Injury in the Immature Rat and Piglet. J Neurotrauma. 2011 May;28(5):763-74. Download PDF
• Eucker SA, Smith C, Ralston J, Friess SH, Margulies SS.Physiological and histopathological responses following closed rotational head injury depend on direction of head motion. Exp Neurol. 2011 Jan;227(1):79-88. Download PDF
• Naim MY, Friess S, Smith C, Ralston J, Ryall K, Helfaer MA, Margulies SS. Folic Acid Enhances Early Functional Recovery in a Piglet Model of Pediatric Head Injury. Dev Neurosci. 2010;32(5-6):466-79. Download PDF
• Ibrahim NG and Margulies SS.  Biomechanics of the Toddler Head During Low Height Falls: An Anthropomorphic Dummy Analysis.  J Neurosurgery-Pediatrics. 2010 Jul;6(1):57-68. Featured Paper. Download PDF
• Ibrahim NG, Ralston J, Smith C, and Margulies SS.  Physiological and Pathological Responses to Head Rotations in Toddler Piglets. J Neurotrauma 2010 Jun;27(6):1021-35. Download PDF
• Coats B, Binenbaum G, Peiffer RL, Forbes B, Margulies SS.  Ocular Hemorrhages in Neonatal Porcine Eyes from Single, Rapid Rotational Events. Invest Ophthalmol Vis Sci. 2010 Apr 30. Download PDF
• Eucker SA, Hoffman BD, Natesh R, Ralston J, Armstead WM and Margulies SS. Development Of A Fluorescent Microsphere Technique For Rapid Histological Determination of Cerebral Blood Flow. Brain Research. 2010 Apr 22;1326:128-34. Download PDF
• Ibrahim, NG, Natesh R, Szczesny SE, Ryall K, Eucker SA, Coats B, and Margulies SS. In Situ Deformations in the Immature Brain During Rapid Rotations.  J Biomech Eng. 2010 Apr;132(4):044501 Download PDF
• Margulies SS, Coats B, Christian C, Forbes B, Duhaime AC.  What Can We Learn from Computational Model Studies of the Eye? Invited Commentary. J AAPOS 2009, 13(4):332. Download PDF
• Zhou C, Eucker S, Durduran T, Yu G, Ralston J, Friess, SH, Ichord RN, Margulies SS and Yodh AG.  Diffuse Optical Monitoring of Hemodynamic Changes in Piglet Brain with Closed Head Injury. J Biomed Optics 2009: 14(3): 034015 (June 4, 2009). Download PDF
• Friess SH, Ichord R, Owens K, Ralston J, Ryall K, Helfaer M, Smith C, and Margulies SS. Repeated traumatic brain injury affects composite cognitive function in piglets. Journal of Neurotrauma 2009: 26:1111-1121. Download PDF
• Margulies SS, Hicks, R and the Combination Therapies for Traumatic Brain Injury Workshop Leaders. Combination Therapies for Traumatic Brain Injury – Prospective Considerations. J. Neurotrauma 2009: 26:925-939.
• Coats B and Margulies SS. Potential for Head Injuries in Infants from Low Height Falls. Journal of Neurosurgery – Pediatrics 2008 Nov, 2(5):321-30. (Selected for Editorial Comment and journal cover) Download PDF
• Coats B, Ji S and Margulies SS. Parametric Study of Head Impact in the Infant. Stapp Car Crash Journal 2007: 51:1-16. Download PDF
• Friess SH, Ichord R, Owens K, Ralston J, Overall K, Smith C, Helfaer M, and Margulies SS. Neurobehavioral Functional Deficits Following Closed Head Injury in the Neonatal Pig. Exper Neurol 2007: 204:234-243. Download PDF
• Ichord R, Naim M, Pollack A, Ibrahim N, Christian C, and Margulies SS. Ischemic Injury Complicates Traumatic Brain Injury in Infants. J Neurotrauma (Invited) 2007: 24:106-118. Download PDF
• Ji S and Margulies SS. In Vivo Pons Motion within the Skull J. Biomech 2007: 40:92-99. Download PDF
• Ning X, Zhu Q, Lanir Y, and Margulies SS. A Transversely Isotropic Viscoelastic Constitutive Model for Brainstem Undergoing Finite Deformation. J Biomech Eng. 2006 128(6):925-33. Download PDF
• Coats BS and Margulies SS. Material Properties of Human Infant Skull and Suture at High Rates. J Neurotrauma 2006: 23(8):1222-1232. Download PDF
• Levchakov A, Linder-Ganz E, Raghupathi R, Margulies SS, and A Gefen Computational Studies of Strain Exposures in Neonate and Mature Rat Brain During Cortical Impact J Neurotrauma 2006:1570-1580. Download PDF
• Zhu Q, Prange M., Margulies SS. Predicting Unconsciousness From a Pediatric Brain Injury Threshold. Developmental. Neurosci (Invited) 2006:28:388-395. Download PDF
• Margulies SS, Prange M, Myers B, Maltese MR, Ji S, Ning, X, Fisher J, Arbogast K, Christian C. Shaken Baby Syndrome: A Flawed Biomechanical Analysis. Letter to the Editor, Forensic Science International 2006: 164:278-279. Download PDF
• Coats BS and Margulies SS. Material Properties of Porcine Parietal Cortex. J Biomech 2006:39: 2521-2525. Download PDF
• Arbogast KB, Margulies SS and Christian CW. Initial Neurological Presentation in Young Children Sustaining Inflicted and Unintentional Fatal Head Injuries. Pediatrics 2005; 116: 180-184. Download PDF
• Ji S, Dougherty L, Margulies SS. In vivo measurements of human brain displacement. Proc of 48th Stapp Car Crash Conference, SAE, 2004. Download PDF
• Gefen A and Margulies SS. Are in vivo and in situ brain tissues mechanically similar? Journal of Biomechanics, 37:1339-1352, 2004. Download PDF
• Raghupathi, R, Mehr MF, Helfaer MA, and Margulies SS. Traumatic axonal injury is exacerbated following repetitive closed head injury in the neonatal pig. Journal of Neurotrauma, 21:307-316, 2004. Download PDF
• Gefen A, Gefen N, Zhu Q, Raghupathi R, and Marguiles SS. Age-Dependent changes in material properties of the brain and braincase of the rat. Journal of Neurotrauma, 20:1163-1177, 2003. Download PDF
• Prange MT, Coats B, Duhaime AC, Margulies SS. Anthropomorphic simulations of falls, shakes, and inflicted impacts for infants. Journal of Neurosurgery, 99:143-150, 2003. Download PDF
• Coats B and Margulies SS. Characterization of pediatric porcine skull properties during impact. Int Conf of Biomech of Impact, 57-66, 2003.
• Raghupathi, R and Margulies SS. Traumatic axonal injury following closed head injury in the neonatal pig. Journal of Neurotrauma, 19:843-853, 2002. Download PDF
• Prange MT and Margulies SS. Regional, directional and age-dependent properties of brain undergoing large deformation. Journal of Biomechanical Engineering, 124:244-252, 2002. Download PDF
• Meaney DF, Margulies SS, Smith DH. “Diffuse axonal injury.” [Letter] Journal of Neurosurgery, 95(6):1108-10, 2001. Download PDF
• Duhaime AC, Margulies SS, Durham SR, O’Rourke MM, Golden JA, Marwaha S, Raghupathi R. Maturation-dependent response of the piglet brain to scaled cortical impact. Journal of Neurosurgery, 93(3):455-462, 2000. Download PDF
• Margulies SS and Thibault KL. Infant skull and suture properties: measurements and implications for mechanisms of pediatric brain injury. Journal of Bioimechanical Engineering, 122:364-371, 2000. Download PDF
• Morrison B, Meaney DF, Margulies SS, McIntosh TK. Dynamic mechanical stretch of organotypic brain slice cultures induces differential genomic expression: relationship to mechanical parameters. Journal of Biomechanical Engineering, 122:224-230, 2000. (Winner of the 2001 American Society of Mechanical Engineers Richard Skalak Best Paper Award) Download PDF
• Prange MT, Meaney DF, Margulies SS. Defining brain mechanical properties: effects of region, direction, and species. 44th Stapp Car Crash Conference, 2000.
• Arbogast KB and Margulies SS. A fiber-reinforced composite model of the viscoelastic behavior material characterization of the brainstem in shear. Journal of Biomechanics, 32(8):865-70, 1999 Aug. Download PDF
• Prange MT, Kiralyfalvi G, Margulies SS. Pediatric Rotational Inertial Brain Injury: The Relative Influence of Brain Size and Material Properties. Proc of 43rd Stapp Car Crash Conf, SAE, 1999 p 333-341. (Stapp Award Recipient)
• Margulies SS, Meaney DF, Smith D, Chen X-H, Miller R, Raghupathi R. A comparison of diffuse brain injury in the newborn and adult pig. Int. Comm for Biokinetics of Impact, 1999.
• Thibault KL and Margulies SS. Age Dependent Material Properties of Porcine Cerebrum: Effect on Pediatric Inertial Head Injury Criteria. Journal of Biomechanics, 31:1119-1126, 1998. Download PDF
• Arbogast KB and Margulies SS. Material characterization of the brainstem from shear oscillatory tests. Journal of Biomechanics. 1998; 31(9):801-7. Download PDF
• Miller RT, Margulies SS, Leoni M, Nonaka M, Chen X, Smith DH, and Meaney DF. Finite element modeling approaches for predicting experimental brain injury in an experimental model of severe diffuse axonal head injury: Proc of 42nd Stapp Car Crash Conf, SAE, 1998. (Stapp Award Recipient)
• Margulies SS, Yuan, Guccione SJ, Weiss MS. Kinematic response of the neck to voluntary and involuntary flexion. J Aviation Sp Environ Med 1998, 69(9):896-903.
• Yuan Q. Dougherty L. and Margulies SS. In vivo cervical spinal cord deformation and displacement in flexion. Spine 1998; 23(15): 1677-1683.
• Arbogast KB, Thibault KL, Pinheiro BS, Winey KI, and Margulies SS. A High-Frequency Shear Device For Testing Soft Biological Tissues. Journal of Biomechanics, Vol 30(7):757-759, 1997. Download PDF
• Arbogast K and Margulies SS. Regional differences in mechanical properties of the central nervous system: Proc of 41st Stapp Car Crash Conf, SAE, 1997 p 293-300. Also published in SAE Tranasactions, 1997, Paper #973336.
• Yuan Q., Dougherty L, and Margulies SS.  In Vivo Spinal Cord Deformation in Flexion, Proc. SPIE Conference, International Society for Optical Engineering, Newport Beach, CA., 1997 (invited).
• Arbogast KB, Prange MT, Meaney DF., and Margulies S. Properties of Cerebral Gray and White Matter Undergoing Large Deformation.  Prevention Through Biomechanics Symposium Proceedings, 1997 (invited).
• Thibault KL and Margulis SS. Material properties of the developing porcine brain. Int. Comm for Biokinetics of Impact. 75-85, 1996.
• Thibault K, Radin A, and Margulies S.  Age-Dependent Properties of Porcine Skull.  Prevention Through Biomechanics Symposium Proceedings, 1996:3-10 (invited).
• Duhaime AC, Epplely M, Margulies SS, Heher KL, Bartlett SP. Crush injuries to the head in children. Neurosurgery, 37:401-407, 1995.
• Margulies SS and Thibault LE. A proposed tolerance criteriaon for diffuse axonal injury in man. Journal of Biomechanics, 25:7-23, 1992. Download PDF
• Margulies SS, Thibault LE, and Gennarelli TA. Physical model simulations of brain injury in the primate. Journal of Biomechanics, 23:832-836, 1990.
• Thibault LE, Gennarelli TA, Margulies SS, Marcus JM, Eppinger R. The strain dependent pathophysiological consequences of inertial loading on central nervous system tissue. Proc Int Res Council on Biokinetics of Impact 1990.
• Margulies SS and Thibault LE. An analytical model of traumatic diffuse brain injury. Journal of Biomechanial Engineering, 111:241-49, 1989.
• Duhaime AC, Gennarelli TA, Thibault LE, Bruce DA, Margulies SS, Wiser R. The shaken baby syndrome – a clinical, pathological, and biomechanical study. Journal of Neurosurgery, 66:409-15, 1987. Download PDF
• Thibault LE, Margulies SS, Gennarelli TA. The temporal and spatial deformation response of a brain model in inertial loading. Proc of 31st Stapp Car Crash Conf, SAE, 1987, p 267-272.
• Margulies SS, Thibault LE, Gennarelli TA. A study of scaling and head injury using physical model experiments. Proc Int Res Council on Biokinetics of Impacts, 1985, p 223-234.

Book Chapters

• National Research Council. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture. Washington, DC: The National Academies Press, 2013.
• Margulies SS and Coats B. Biomechanics of pediatric TBI. In V. Anderson & K. Yeates (Eds), Pediatric Traumatic Brain Injury: New Frontiers in Clinical and Translational Research. New York: Cambridge University Press. (2010)
• Margulies SS. and Coats B. “Biomechanics of Head Trauma in Infants and Young Children” in Child Abuse and Neglect: Diagnosis, Treatment and Evidence. Dr. Carol Jenny Ed. Elsevier Press (in press) 2009.
• Coats B and Margulies SS. Material properties of the pediatric head (Chapter 5) in Pediatric Injury Biomechanics. National Highway Traffic Safety Administration (In Press) 2009.
• Arbogast KB, Margulies SS, Patlak M, Fenner H, Thomas DJ. “Head and Neck Injury: Implications for Helmet Standards” Summary of a conference held at The Children’s Hospital of Philadelphia, Philadelphia, PA on March 31, 2003. Published by Snell Memorial Foundation.
• Margulies SS and Spivack BS. “Pathobiology and Biomechanics of Inflicted Childhood Neurotrauma” in Inflicted Childhood Neurotrauma, American Academy of Pediatrics, 2003. RM Reece and CE Nicholson eds. pp. 221-236.
• Laurer HL, Meaney DF, Margulies SS and McIntosh TK, “Modeling Brain Injury/Trauma” in Encyclopedia of the Human Brain, Vol 4, Academic Press, Elsevier Science and Technology Books, Ramachandran, VS, Editor.
• Margulies SS and Meaney DF, “Physical Characteristics of Human Brain Tissue” in Handbook of Biomaterials Properties , Chapman and Hall, J Black and G Hastings eds., pp.70-80.

Lung Injury Publications

• Yehya N, Fazelinia H, Taylor DM, Lawrence GG, Spruce LA, Thompson JM, Margulies SS, Seeholzer SH, Worthen GS. Differentiating children with sepsis with and without acute respiratory distress syndrome using proteomics. Am J Physiol Lung Cell Mol Physiol. Mar 2022;322(3):L365-L372. https://10.1152/ajplung.00164.2021.
• Yehya N, Song MJ, Lawrence GG, Margulies SS. HER2 Signaling Implicated in Regulating Alveolar Epithelial Permeability with Cyclic Stretch. Int J Mol Sci. Feb 2019;20(4):948. https://10.3390/ijms20040948.
• Dolinay T, Aonbangken C, Zacharias W, Cantu E, Pogoriler J, Stablow A, Lawrence GG, Suzuki Y, Chenoweth DM, Morrisey E, Christie JD, Beers MF, Margulies SS. Protein kinase R-like endoplasmic reticulum kinase is a mediator of stretch in ventilator-induced lung injury. Resp Res (2018) 19:157. doi: 10.1186/s12931-018-0856-2. PMID: 30134920, PMCID: PMC6106739.
• Zubrow M, Margulies SS, Yehya N. 24: Ndga Improves Survival and Degree of Lung Injury in Rats After Cecal Ligation and Puncture. Crit Car Med. Jan 2018;46(1):12. doi: 10.1097/01.ccm.0000528080.77878.8c
• Dolinay T, Himes B, Shumyatcher M, Gray Lawrence G, Margulies SS. Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.Am J Resp Cell and Molec Bio. 2017 Aug; 57(2): 193-203. PMID 28363030, PMCID: PMC5576586.
• Yehya N, Thomas N, Meyer NJ, Christie JD, Berg RA,Margulies SS. Circulating Markers of Endothelial and Alveolar Epithelial Dysfunction Associate with Mortality in Pediatric Acute Respiratory Distress Syndrome. Intensive Care Med. 2016 Jul;42(7):1137-45. PMID: 27101828.
• Yehya N, Thomas N, Margulies SS. Circulating Nucleosomes are Associated with Mortality in Pediatric Acute Respiratory Distress Syndrome. Am. J. Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1177-84. PMID: 27130528, PMCID: PMC4935473.
• Song MJ, Davis CI, Lawrence GG, Margulies SS.Local influence of cell death on stretch-induced permeability of alveolar epithelial cell monolayers. Cell Mol Bioeng. 2016 Mar 1;9(1):65-72. PMID: 26958093, PMCID: PMC4779366.
• Song MJ, Davidovich N, Lawrence GG, Margulies SS. Superoxide Mediates Tight Junction Complex Dissociation in Cyclically Stretched Lung Slices. J. Biomech. Special Issue: Motility and Dynamics of Living Cells in Health, Disease, and Healing. 2015 Nov 11. PMID: 26592435.
• Yehya N, Xin Y, Oquendo Y, Cereda M, Rizi R, Margulies SS. Cecal ligation and puncture accelerates development of ventilator-induced lung injury. American Journal of Physiology – Lung, Cellular and Molecular Physiology. 2015 Mar 1; 308(5):L443-51. PMID: 25550313, PMCID: PMC4346777.
• Goncharova EA, Goncharov DA, James ML, Fehrenbach M, Atochina-Vasserman EN, Stepanova V, Hong SB, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies SS, Guttentag S, Schmidt LS, Krymskaya VP. Folliculin controls lung alveolar enlargement and epithelial cell survival through E-Cadherin, LKB1 and AMPK. Cell. 2014 Apr 24; 7(2):412-23. PMID: 24726356.
• Davidovich N, Chhour P, Margulies SS. Uses of Remnant Human Lung Tissue for Mechanical Stretch Studies.Cell Mol Bioeng. 2013 Jun 1;6(2):175-182. Download PDF
• Dipaolo BC, Davidovich N, Kazanietz MG, Margulies SS. Rac1 Pathway Mediates Stretch Response in Pulmonary Alveolar Epithelial Cells. Am J Physiol Lung Cell Mol Physiol. 2013 May 17.
• Davidovich N, Dipaolo BC, Lawrence GG, Chhour P, Yehya N, Margulies SS.Cyclic Stretch-Induced Oxidative Stress Increases Pulmonary Alveolar Epithelial Permeability. Am J Respir Cell Mol Biol. 2013 Mar 22.
• Davidovich N, Huang J, Margulies SS. Reproducible uniform equibiaxial stretch of precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2013 Feb;304(4):L210-20. Download PDF
• Cohen TS, DiPaolo BC, Lawrence GG, Margulies SS. Sepsis enhances epithelial permeability with stretch in an actin dependent manner. PLoS One. 2012;7(6). Download PDF
• Yehya N, Yerrapureddy A, Tobias J, Margulies SS. MicroRNA modulate alveolar epithelial response to cyclic stretch. BMC Genomics. 2012 Apr 26;13:154. Download PDF
• Dipaolo BC, Margulies SS. Rho kinase signaling pathways during stretch in primary alveolar epithelia. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 27. Download PDF
• Mitchell LA, Overgaard CE, Ward C, Margulies SS, Koval M. Differential Effects of Claudin-3 and Claudin-4 on Alveolar Epithelial Barrier Function. Am J Physiol Lung Cell Mol Physiol. 2011 Apr 22. Download PDF
• Cohen TS, Bucki R, Byfield FJ, Ciccarelli NJ, Rosenberg B, Dinubile MJ, Janmey PA, Margulies SS. Therapeutic Potential of Plasma Gelsolin Administration in a Rat Model of Sepsis. Cytokine. 2011 Jun;54(3):235-8. Download PDF
• DiPaolo BC, Lenormand G, Fredberg JJ, Margulies SS. Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epithelia. Am J Physiol Cell Physiol. 2010 Aug;299(2):C345-53. Download PDF
• Cohen TS, Gray Lawrence G, Margulies SS. Cultured alveolar epithelial cells from septic rats mimic in vivo septic lung. PLoS One. 2010 Jun 25;5(6):e11322. Download PDF
• Cohen TS, Gray Lawrence G, Khasgiwala A, Margulies SS. MAPK activation modulates permeability of isolated rat alveolar epithelial cell monolayers following cyclic stretch. PLoS One. 2010 Apr 28;5(4):e10385. Download PDF
• Foster CD, Varghese LS, Gonzales LW, Margulies SS and Guttentag SH.  The Rho Pathway Mediates Transition to an Alveolar Type I Phenotype during Static Stretch of Alveolar Type II Cells.  Ped Research 2010 Jun;67(6):585-90. Download PDF
• Yerrapureddy A, Tobias J, and Margulies SS.  Cyclic Stretch Magnitude and Duration Affect Rat Alveolar Epithelial Gene Expression. Cell Physiol Biochem 2010, 25:113-122. Download PDF
• Cohen TS, Cavanaugh KJ and Margulies SS. Frequency and Peak Stretch Magnitude Affect Alveolar Epithelial Permeability. Eur Resp J 2008 32(4):854-61. Download PDF
• Van Driessche W, Kreindler JL, Malik AB, Margulies S, Lewis SA, and Kim KJ Interrelations/crosstalk Between Transcellular Transport Function and Paracellular Tight Junctional Properties in Lung Epithelial and Endothelial Barriers. AJP-Lung Cellular and Molecular Physiology 2007: 293(3):L520-4. Download PDF
• Brennick MJ. Gefter WB. Margulies SS. Mechanical effects of genioglossus muscle stimulation on the pharyngeal airway by MRI in cats. Respiratory Physiology & Neurobiology. 2007: 156(2):154-64. Download PDF
• Fisher JL and Margulies SS. Modeling the Effect of Stretch and Plasma Membrane Tension on Na+/K+-ATPase in Alveolar Epithelial Cells. Am J Physiol -Cell 2007:292:L40-L53. Download PDF
• Levine G, Deutschman C, Helfaer M and Margulies SS. Sepsis Induced Lung Injury in Rats Increases Alveolar Epithelial Vulnerability to Stretch. Crit Care Med 2006:34: 1746-1751. Download PDF
• Cavanaugh KJ, Cohen TS and Margulies SS. Stretch increases alveolar epithelial permeability to uncharged micromolecules. Am J Physiol-Cell 2006; 290:C1179-1188. Download PDF
• Patel A, Reigada D, Mitchell CH, Bates SR, Margulies SS. Koval M. Paracrine stimulation of surfactant secretion by extracellular ATP in response to mechanical deformation. Am J Physiol – Lung Cell Mol 2005: 287:L1266-L1273. Download PDF
• Fisher JL, Levitan I, and Margulies SS. Plasma membrane surface increases with tonic stretch of alveolar epithelial cells. Am. J. Resp. Cell Mol Biol 2004:31:200-208. Download PDF
• Levinson H, Liu W, Oswari J, Peled Z, Hsu M, Longaker MT, Margulies SS. “Extracellular matrix and seeding density affect cell response to mechanical strain.” Journal of Burns. Volume 1, 2002.
• Cavanaugh KJ and Margulies SS. Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro method. Am J Physiol – Cell Physiol, 283:C1801-C1808, 2002. Download PDF
• Fisher JL and Margulies SS. Na(+)-K(+)-ATPase activity in alveolar epithelial cells increases with cyclic stretch. J. Applied Physiology, 283:L737-L746, 2002. Download PDF
• Cavanaugh KJ, Oswari J, Margulies SS. Role of stretch on tight junction structure in alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 25:584-591, 2001, Nov. Download PDF
• Oswari J, Matthay MA, Margulies SS. Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformation. Am J Physiology, 281:L1068-L1077, 2001. Download PDF
• Tschumperlin DJ, Oswari J, Margulies SS. Deformation-induced injury of alveolar epithelial cells: effect of frequency, duration, and amplitude. Am J. Resp and Crit Care Med, 152:357-362, 2000. Download PDF
• Tschumperlin DJ and Margulies SS. Alveolar Epithelial Surface Area – volume relationship in isolated rat lungs. Journal of Applied Physiology 86(6):2026-33, 1999 Jun. Download PDF
• Brennick MJ, Ogivie MD, Margulies SS, Hiller L, Gefter WB and Pack AI. MRI study of regional variations of pharyngeal wall compliance in cats. Journal of Applied Physiology. 85(5):1884-97, 1998 Nov. Download PDF
• Tschumperlin DJ and Margulies SS. Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro. American Journal of Physiology – Lung 275(6 Pt 1):L1173-83, 1998 Dec. Download PDF
• Boriek AM, Rodarte JR, Margulies SS. The zone of apposition in the passive diaphragm of the dog. Journal of Applied Physiology, 81:1929-40, 1996. Download PDF
• Hubmayr RD and Margulies SS. Regional ventilation in statically and dynamically hyperinflated dogs. Journal of Applied Physiology, 81:1815-21, 1996. Download PDF
• Margulies SS, Lei GT, Farkas GA, Rodarte JR. Finite element anaysis of stress in the canine diaphragm. Journal of Applied Physiology, 76:2070-75, 1994. Download PDF
• Hubmayr RD, Farkas GA, Tao H-Y, Sieck GC, Margulies SS. Diaphragm mechanics in dogs with unilateral emphysema. J Clin Invest 91:1598-1603, 1993. Download PDF
• Hubmayr RD, Margulies SS. Effects of unilateral hyperinflation on the interpulmonary distribution of pleural pressure. J Appl Physiol 73(4):1650-1654, 1992. Download PDF
• Margulies SS, Schriner RW, Schroeder MA, Hubmayr RD. Static lung-lung interactions in unilateral emphysema. J Appl Physiol ,73(2):545-551, 1992. Download PDF
• Margulies SS. Regional variation in canine diaphragm thickness. Journal of Applied Physiology, 70:2663-68, 1991. Download PDF
• Sprung J, Deschamps C, Margulies SS, Hubmayr RD, Rodarte JR. Effect of body position on regional diaphragm function in dogs. J Appl Physiol, 69:2296-2302, 1990. Download PDF
• Margulies SS, Farkas GA, Rodarte JR. Effects of body position and lung volume on in situ operating length of canine diaphragm. J Appl Physiol, 69:1702-1708, 1990. Download PDF
• Liu S, Margulies SS, Wilson TA. Deformation of the dog lung in the chest wall. J Appl Physiol, 68:1979-1987, 1990. Download PDF
• Margulies SS, Rodarte JR. Shape of the chest wall in the prone and supine anesthetized dog. J Appl Physiol, 68:1970-1978, 1990. Download PDF
• Margulies SS, Rodarte JR, Hoffman EA. Geometry and kinematics of dog ribs. J Appl Physiol, 67:707-712, 1989. Download PDF