The tectorial membrane is an extracellular matrix located on top of the outer hair cells in the mammalian cochlea. Even though the tectorial membrane is known to be an important component of the cochlea, many unknowns remain regarding its role. In this research, we collaborate with Dr. Freeman’s group (MIT) who provide us experimental measurements of wave propagation on isolated tectorial membrane segments. We then use finite element models to determine, within the auditory frequency range, the anisotropic viscoelastic properties of the tectorial membrane. In order to understand how the composition of the tectorial membrane affects its properties, we apply this technique the tectorial membrane of both wild-type and genetically modified mice. The mechanical properties of the tectorial membrane will be then inserted in finite element models of the cochlea to predict how these properties influence cochlear function.
Publications:
- Lemons, C., Sellon, J.B., Boatti, E., Filizzola, D., Freeman, D.M., Meaud, J., 2019, Anisotropic material properties of wild-type and Tectb-/- tectorial membranes, Biophysical Journal, 116(3):573-585