Publications
* co-first authors, # Mejías undergraduate trainee, +co-last authors
2025
Hooks JST, Yang B, Maestas DR Jr, Andorko JI, Ruta A, Mejias JC, Kelly SH, Hee CK, Elisseeff JH. Innate and Adaptive Immune Responses to Clinical Hyaluronic Acid Fillers. J Cosmet Dermatol. 2025 Jul;24(7):e70292. doi: 10.1111/jocd.70292. PubMed PMID: 40635637; PubMed Central PMCID: PMC12242719.
[Preprint] Rutkowski N, Yang B, Gray-Gaillard E, Ruta A, Mejías JC, Patatanian M, Cherry C, Stivers KB, Ramanujam S, Price NL, Housseau F, Pardoll DM, Sears CL, Elisseeff JH. Antibiotic-induced microbiota depletion impairs the pro-regenerative response to a biological scaffold in mice. bioRxiv. 2025 Jun 27;. doi: 10.1101/2025.06.23.661121. PubMed PMID: 40667290; PubMed Central PMCID: PMC12262383.
Yang B, Rutkowski N, Ruta A, Gray-Gaillard E, Maestas DR Jr, Kelly SH, Krishnan K, Wu X, Wu S, Chen A, Mejías JC, Hooks JST, Vanderzee I, Mensah P, Celik N, Eric M, Abraham P, Tam A, Housseau F, Pardoll DM, Sears CL, Elisseeff JH. Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2422169122. doi: 10.1073/pnas.2422169122. Epub 2025 May 12. PubMed PMID: 40354538; PubMed Central PMCID: PMC12107164.
2024
Han J, Cherry C, Mejías JC, Krishnan K, Ruta A, Maestas DR Jr, Peña AN, Nguyen HH, Nagaraj S, Yang B, Gray-Gaillard EF, Rutkowski N, Browne M, Tam AJ, Fertig EJ, Housseau F, Ganguly S, Moore EM, Pardoll DM, Elisseeff JH. Age-associated Senescent – T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response. Adv Mater. 2024 Oct;36(43):e2310476. doi: 10.1002/adma.202310476. Epub 2023 Dec 28. PubMed PMID: 38087458.
2023
Cherry C, Andorko JI, Krishnan K, Mejías JC, Nguyen HH, Stivers KB, Gray-Gaillard EF, Ruta A, Han J, Hamada N, Hamada M, Sturmlechner I, Trewartha S, Michel JH, Davenport Huyer L, Wolf MT, Tam AJ, Peña AN, Keerthivasan S, Le Saux CJ, Fertig EJ, Baker DJ, Housseau F, van Deursen JM, Pardoll DM, Elisseeff JH. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. Geroscience. 2023 Aug;45(4):2559-2587. doi: 10.1007/s11357-023-00785-7. Epub 2023 Apr 20. PubMed PMID: 37079217; PubMed Central PMCID: PMC10651581.
Sommerfeld SD, Zhou X, Mejías JC*, Oh BC, Maestas DR Jr, Furtmüller GJ, Laffont PA, Elisseeff JH, Brandacher G. Biomaterials-based immunomodulation enhances survival of murine vascularized composite allografts. Biomater Sci. 2023 May 30;11(11):4022-4031. doi: 10.1039/d2bm01845d. PubMed PMID: 37129566.
Maestas DR Jr, Chung L, Han J, Wang X, Sommerfeld SD, Kelly SH, Moore E, Nguyen HH, Mejías JC, Peña AN, Zhang H, Hooks JST, Chin AF, Andorko JI, Berlinicke CA, Krishnan K, Choi Y, Anderson AE, Mahatme R, Mejia C, Eric M, Woo J, Ganguly S, Zack DJ, Zhao L, Pearce EJ, Housseau F, Pardoll DM, Elisseeff JH. Helminth egg derivatives as proregenerative immunotherapies. Proc Natl Acad Sci U S A. 2023 Feb 21;120(8):e2211703120. doi: 10.1073/pnas.2211703120. Epub 2023 Feb 13. PubMed PMID: 36780522; PubMed Central PMCID: PMC9974432.
2022
Peña AN, Sommerfeld SD, Anderson AE, Han J, Maestas DR Jr, Mejias JC, Woodell-May J, King W, Ganguly S, Elisseeff JH. Autologous Protein Solution processing alters lymphoid and myeloid cell populations and modulates gene expression dependent on cell type. Arthritis Res Ther. 2022 Sep 12;24(1):221. doi: 10.1186/s13075-022-02875-x. PubMed PMID: 36096945; PubMed Central PMCID: PMC9465964.
2021
Nelson MR, Ghoshal D, Mejías JC, Rubio DF#, Keith E, Roy K. A multi-niche microvascularized human bone marrow (hBM) on-a-chip elucidates key roles of the endosteal niche in hBM physiology. Biomaterials. 2021 Mar;270:120683. doi: 10.1016/j.biomaterials.2021.120683. Epub 2021 Jan 25. PubMed PMID: 33556648.
2020
Mejías JC, Nelson MR, Liseth O#, Roy K. A 96-well format microvascularized human lung-on-a-chip platform for microphysiological modeling of fibrotic diseases. Lab Chip. 2020 Sep 29;20(19):3601-3611. doi: 10.1039/d0lc00644k. PubMed PMID: 32990704.
2019
Mejías JC, Roy K. In-vitro and in-vivo characterization of a multi-stage enzyme-responsive nanoparticle-in-microgel pulmonary drug delivery system. J Control Release. 2019 Dec 28;316:393-403. doi: 10.1016/j.jconrel.2019.09.012. Epub 2019 Nov 9. PubMed PMID: 31715279.
Mejías JC*, Forrest OA*, Margaroli C*, Frey Rubio DA#, Viera L, Li J, Xu X, Gaggar A+, Tirouvanziam R+, Roy K+. Neutrophil-targeted, protease-activated pulmonary drug delivery blocks airway and systemic inflammation. JCI Insight. 2019 Dec 5;4(23). doi: 10.1172/jci.insight.131468. PubMed PMID: 31661469; PubMed Central PMCID: PMC6962027.
2018
Patlan R, Mejias J, McEachin Z, Salinas A, Lozano K. Fabrication and Characterization of Poly(L-lactic Acid) Fiber Mats Using Centrifugal Spinning. Fibers and Polymers. 2018/06; 19(6):1271-1277. doi: 10.1007/s12221-018-7063-0.
2017
Mannino RG, Santiago-Miranda AN, Pradhan P, Qiu Y, Mejias JC, Neelapu SS, Roy K, Lam WA. 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro. Lab Chip. 2017 Jan 31;17(3):407-414. doi: 10.1039/c6lc01204c. PubMed PMID: 28054086; PubMed Central PMCID: PMC5285444.