Research Articles

2021

Atalis, A., Dixon, J. B. & K. Roy 2021. Soluble And Microparticle-Based Delivery Of TLR4 And TLR9 Agonists Differentially Modulate 3D Chemotaxis Of Bone Marrow-Derived Dendritic Cells. Adv Healthc Mater, 10, E2001899.
Cheng, A., Vantucci, C. E., Krishnan, L., Ruehle, M. A., Kotanchek, T., Wood, L. B., K. Roy & Guldberg, R. E. 2021. Early Systemic Immune Biomarkers Predict Bone Regeneration After Trauma. Proc Natl Acad Sci U S A, 118.
Lee, W., Kingstad-Bakke, B., Paulson, B., Larsen, A., Overmyer, K., Marinaik, C. B., Dulli, K., Toy, R., Vogel, G., Mueller, K. P., Tweed, K., Walsh, A. J., Russell, J., Saha, K., Reyes, L., Skala, M. C., Sauer, J. D., Shayakhmetov, D. M., Coon, J., K. Roy & Suresh, M. 2021. Carbomer-Based Adjuvant Elicits CD8 T-Cell Immunity By Inducing A Distinct Metabolic State In Cross-Presenting Dendritic Cells. Plos Pathog, 17, E1009168.
Liu, J., Toy, R., Vantucci, C., Pradhan, P., Zhang, Z., Kuo, K. M., Kubelick, K. P., Huo, D., Wen, J., Kim, J., Lyu, Z., Dhal, S., Atalis, A., Ghosh-Choudhary, S. K., Devereaux, E. J., Gumbart, J. C., Xia, Y., Emelianov, S. Y., Willett, N. J. & K. Roy 2021. Bifunctional Janus Particles As Multivalent Synthetic Nanoparticle Antibodies (SNAbs) For Selective Depletion Of Target Cells. Nano Lett, 21, 875-886.
Nelson, M. R., Ghoshal, D., Mejías, J. C., Rubio, D. F., Keith, E. & K. Roy 2021. A Multi-Niche Microvascularized Human Bone Marrow (hBM) On-A-Chip Elucidates Key Roles Of The Endosteal Niche In hBM Physiology. Biomaterials, 270, 120683.
Toy, R., Keenum, M. C., Pradhan, P., Phang, K., Chen, P., Chukwu, C., Nguyen, L. A. H., Liu, J., Jain, S., Kozlowski, G., Hosten, J., Suthar, M. S. & K. Roy 2021. TLR7 And RIG-I Dual-Adjuvant Loaded Nanoparticles Drive Broadened And Synergistic Responses In Dendritic Cells In Vitro And Generate Unique Cellular Immune Responses In Influenza Vaccination. J Control Release, 330, 866-877.
Vantucci, C. E., Ahn, H., Fulton, T., Schenker, M. L., Pradhan, P., Wood, L. B., Guldberg, R. E., K. Roy & Willett, N. J. 2021. Development Of Systemic Immune Dysregulation In A Rat Trauma Model Of Biomaterial-Associated Infection. Biomaterials, 264, 120405.
Vantucci, C. E., Krishan, L., Cheng, A., Prather, A., K. Roy & Guldberg, R. E. 2021. BMP-2 Delivery Strategy Modulates Local Bone Regeneration And Systemic Immune Responses To Complex Extremity Trauma. Biomater Sci, 9, 1668-1682.

2020

Kingstad-Bakke, B., Toy, R., Lee, W., Pradhan, P., Vogel, G., Marinaik, C. B., Larsen, A., Gates, D., Luu, T., Pandey, B., Kawaoka, Y., K. Roy & Suresh, M. 2020. Polymeric Pathogen-Like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity To Influenza A Virus. Front Immunol, 11, 559382.
Mejías, J. C., Nelson, M. R., Liseth, O. & K. Roy 2020. A 96-Well Format Microvascularized Human Lung-On-A-Chip Platform For Microphysiological Modeling Of Fibrotic Diseases. Lab Chip, 20, 3601-3611.
Stevens, H. Y., Bowles, A. C., Yeago, C. & K. Roy 2020. Molecular Crosstalk Between Macrophages And Mesenchymal Stromal Cells. Front Cell Dev Biol, 8, 600160.

2019

Cheng, A., Krishnan, L., Pradhan, P., Weinstock, L. D., Wood, L. B., K. Roy & Guldberg, R. E. 2019. Impaired Bone Healing Following Treatment Of Established Nonunion Correlates With Serum Cytokine Expression. J Orthop Res, 37, 299-307.
Joyce, J. C., Sella, H. E., Jost, H., Mistilis, M. J., Esser, E. S., Pradhan, P., Toy, R., Collins, M. L., Rota, P. A., K. Roy, Skountzou, I., Compans, R. W., Oberste, M. S., Weldon, W. C., Norman, J. J. & Prausnitz, M. R. 2019. [Extended Delivery Of Vaccines To The Skin Improves Immune Responses]. J Control Release, 304, 135-145.
Mejías, J. C., Forrest, O. A., Margaroli, C., Frey Rubio, D. A., Viera, L., Li, J., Xu, X., Gaggar, A., Tirouvanziam, R. & K. Roy 2019. Neutrophil-Targeted, Protease-Activated Pulmonary Drug Delivery Blocks Airway And Systemic Inflammation. Jci Insight, 4.
Mejías, J. C. & K. Roy 2019. In-Vitro And In-Vivo Characterization Of A Multi-Stage Enzyme-Responsive Nanoparticle-In-Microgel Pulmonary Drug Delivery System. J Control Release, 316, 393-403.
Ruehle, M. A., Krishnan, L., Vantucci, C. E., Wang, Y., Stevens, H. Y., K. Roy, Guldberg, R. E. & Willett, N. J. 2019. Effects Of BMP-2 Dose And Delivery Of Microvascular Fragments On Healing Of Bone Defects With Concomitant Volumetric Muscle Loss. J Orthop Res, 37, 553-561.
Toy, R., Pradhan, P., Ramesh, V., Di Paolo, N. C., Lash, B., Liu, J., Blanchard, E. L., Pinelli, C. J., Santangelo, P. J., Shayakhmetov, D. M. & K. Roy 2019. Modification Of Primary Amines To Higher Order Amines Reduces In Vivo Hematological And Immunotoxicity Of Cationic Nanocarriers Through TLR4 And Complement Pathways. Biomaterials, 225, 119512.

2018

Roh, K. H., Song, H. W., Pradhan, P., Bai, K., Bohannon, C. D., Dale, G., Leleux, J., Jacob, J. & K. Roy. 2018. A Synthetic Stroma-Free Germinal Center Niche For Efficient Generation Of Humoral Immunity Ex Vivo. Biomaterials, 164, 106-120.
Mannino, R. G., Pradhan, P., K. Roy. & Lam, W. A. 2018. 3D In Vitro Microvascular Model-Based Lymphoma Model. Methods Cell Biol, 146, 149-158.

2017

Parratt, K., Smerchansky, M., Stiggers, Q. & K. Roy. 2017. Effect Of Hydrogel Material Composition On HBMSC Differentiation Into Zone-Specific Neo-Cartilage: Engineering Human Articular Cartilage-Like Tissue With Spatially Varying Properties. J Mater Chem B, 5, 6237-6248.
P. Pradhan, J. Leleux, J. Liu, K. Roy. A simple, clinically relevant therapeutic vaccine shows long-term protection in an aggressive, delayed-treatment B lymphoma model. JCI Insight, 2017. DOI: 10.1172/jci.insight.92522.
I. Riviere and K. Roy. Perspectives on Manufacturing of High-Quality Cell Therapies. Mol Ther, 2017. DOI: 10.1016/j.ymthe.2017.04.010
A. Singh and K. Roy. Immuno-engineering: The Next Frontier in Therapeutics Delivery. Adv Drug Deliv Rev, 2017. DOI: 10.1016/j.addr.2017.08.005
C. L. Zhu, P. Pradhan, D. Huo, S. Shen, K. Roy, Y.N. Xia. Reconstitution of Low-Density Lipoproteins with Fatty Acids for the Targeted Delivery of Drugs into Cancer Cells. Angewandte Chemie-International Edition, 2017. DOI: 10.1002/anie.201704674
K. Parratt, J. Jeong, P. Qiu, K. Roy. 3D material cytometry (3DMaC): a very high-replicate, high-throughput analytical method using microfabricated, shape-specific, cell-material niches. Lab on a Chip, 2017. DOI: 10.1039/c7lc00451f
R. G. Mannino, A. N. Santiago-Miranda, P. Pradhan, Y. Z. Qiu, J. C. Mejias, S. S. Neelapu, K. Roy, W. A. Lam. 3D microvascular model recapitulates the diffuse large B-cell lymphoma tumor microenvironment in vitro. Lab on a Chip, 2017. DOI: 10.1039/c6lc01204c
R. Madan-Lala, P. Pradhan, K. Roy. Combinatorial Delivery of Dual and Triple TLR Agonists via Polymeric Pathogen-like Particles Synergistically Enhances Innate and Adaptive Immune Responses. Scientific Reports, 2017. DOI: 10.1038/s41598-017-02804-y
J. A. Leleux, P. Pradhan, K. Roy. Biophysical Attributes of CpG Presentation Control TLR9 Signaling to Differentially Polarize Systemic Immune Responses. Cell Reports, 2017. DOI: 10.1016/j.celrep.2016.12.073
P. Jurney, R. Agarwal, V. Singh, D. Choi, K. Roy, S.V. Sreenivasan, L. Shi. Unique size and shape-dependent uptake behaviors of non-spherical nanoparticles by endothelial cells due to a shearing flow. Journal of Controlled Release, 2017. DOI: 10.1016/j.jconrel.2016.11.033
N. J. Dwarshuis, K. Parratt, A. Santiago-Miranda, K. Roy. Cells as advanced therapeutics: State-of-the-art, challenges, and opportunities in large scale biomanufacturing of high-quality cells for adoptive immunotherapies. Adv Drug Deliv Rev, 2017. DOI: 10.1016/j.addr.2017.06.005
E. Dawson, J. A. Leleux, P. Pradhan, K. Roy. Surface-Presentation of CpG and Protein-Antigen on Pathogen-Like Polymer Particles Generate Strong Prophylactic and Therapeutic Antitumor Protection. ACS Biomaterials Science & Engineering, 2017. DOI: 10.1021/acsbiomaterials.6b00384

2016

R. Toy and K. Roy. Engineering Nanoparticles to Overcome Barriers to Immunotherapy. Bioengineering & Translational Medicine, 2016. DOI: 10.1002/btm2.10005
K.H. Roh and K. Roy. Engineering approaches for regeneration of T lymphopoiesis. Biomater Res. 2016 Jun 29;20:20. doi: 10.1186/s40824-016-0067-1. eCollection 2016. PubMed
K.H. Roh, R.M. Nerem, and K. Roy. Biomanufacturing of Therapeutic Cells: State of the Art, Current Challenges, and Future Perspectives. Annu Rev Chem Biomol Eng. 2016 Jun 7;7:455-78. doi: 10.1146/annurev-chembioeng-080615-033559. PubMed
M.R. Nelson and K. Roy. Bone-marrow mimicking biomaterial niches for studying hematopoietic stem and progenitor cells. J. Mater. Chem. B, 2016,4, 3490-3503. DOI: 10.1039/C5TB02644J
S. Lee, M. T. Nguyen, M. G. Currier, J. B. Jenkins, E. A. Strobert, A. E. Kajon, R. Madan-Lala, Y. A. Bochkov, J. E. Gern, K. Roy, X. Y. Lu, D. D. Erdman, P. Spearman, M. L. Moore. A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques. Nature Communications, 2016. DOI: 10.1038/ncomms12838

2015

J. Leleux, A. Atalis, and K. Roy. Engineering immunity: Modulating dendritic cell subsets and lymph node response to direct immune-polarization and vaccine efficacy.J Control Release. 2015 Dec 10;219:610-21. doi: 10.1016/j.jconrel.2015.09.063. Epub 2015 Oct 20.
R. Agarwal, P. Jurney, M. Raythatha, V. Singh, S.V. Sreenivasan, L. Shi, K. Roy. Effect of shape, size, and aspect ratio on nanoparticle penetration and distribution inside solid tissues using 3D spheroid models.Adv Healthc Mater. 2015 Oct 28;4(15):2269-80. doi: 10.1002/adhm.201500441. Epub 2015 Sep 16.

2014

V. Singh, R. Agarwal, K. Roy., L. Shi, S.V. Sreenivasan. Scalable Fabrication of Ultra-Soft Shape Specific Nanocarriers for Diagnostics and Drug Delivery. Journal of Micro and Nano-Manufacturing. Epub 2014 Oct; doi:10.1115/1.4028896. ASME
S. Li, K.K. Hirschi, K. Roy. Induced Pluripotent Stem Cells for Regenerative Medicine, Annu Rev Biomed Eng. 2014 Jul;16:277-94. doi: 10.1146/annurev-bioeng-071813-105108. ASME
P. Pradhan, H. Qin, J.A. Leleux, D. Gwak, I. Sakamaki, L.W. Kwak, K. Roy. The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma. Biomaterials. 2014 Jul; 35(21):5491-504. doi: 10.1016/j.biomaterials.2014.03.039. PubMed
A. Purwada, K. Roy, A. Singh. Engineering vaccines and niches for immune modulation, Acta Biomaterialia. 2014, Apr:10(4):1728-1740.doi:10.1016/j.actbio.2013.12.036. PubMed
J.S. Lewis, K. Roy, B.G. Keselowsky. Materials that harness and modulate the immune system, MRS Bulletin 39 (01), 25-34. CJO
I. Fernandez, T.P. Ooi, K. Roy. Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous notch and tetramer-TCR signaling. Stem Cells. 2014 Jan; 32(1). doi: 10.1002/stem.1512. PubMed

2013

P. Jurney, R. Agarwal, V. Singh, K. Roy., S.V. Sreenivasan, L. Shi. Size-Dependent Nanoparticle Margination and Adhesion Propensity in a Microchannel. Journal of Nanotechnology in Engineering and Medicine. 2013 Nov;4(3). doi: 10.1115/1.4025609. ASME
R. Agarwal, V. Singh, P. Jurney, S.V. Sreenivasan, L. Shi, K. Roy. Cells Prefer Hydrogel Nanodiscs over Nanorods and Use Shape-specific Uptake Mechanisms. Proc Natl Acad Sci USA. 2013 Oct;110(43):17247-52. doi: 10.1073/pnas.1305000110. PNAS
R. Agarwal, K. Roy. Intracellular Delivery of Polymeric Nanocarriers: A Matter of Size, Shape, Charge, Elasticity and Surface Composition. , Therapeutics Delivery. 2013 Jun;4(6):705-23. doi: 10.4155/tde.13.37. Pubmed
J. Leleux, K. Roy. Micro and nanoparticle-based delivery systems for vaccine immunotherapy: an immunological and materials perspective. Adv Healthc Mater. 2013 Jan;2(1):72-94. doi: 10.1002/adhm.201200268. Pubmed

2012

I. Fernandez, K. Fridley, D. Arasappan, R. Ambler, P.W. Tucker, K. Roy. Gene expression profile and functionality of ESC-derived Lin-ckit+Sca-1+ cells are distinct from Lin-ckit+Sca-1+ cells isolated from fetal liver or bone marrow. PLoS One. 2012;7(12) doi: 10.1371/journal.pone.0051944. PubMed
P. Wanakule, G.W. Liu, A.T. Fleury, K. Roy. Nano-inside-micro: Disease-responsive microgels with encapsulated nanoparticles for intracellular drug delivery to the deep lung. Journal of Controlled Release. 2012 Jul;162(2):429-437. doi: 10.1016/j.jconrel.2012.07.026. PubMed
R. Agarwal, V. Singh, P. Jurney, L. Shi, S.V. Sreenivasan, K. Roy. Scalable imprinting of shape- specific polymeric nanocarriers using a release layer of switchable water solubility. ACS Nano. 2012 Mar; 6(3):2524-2531. doi: 10.1021/nn2049152. PubMed
P. Wanakule, K. Roy. Disease-Responsive Drug Delivery: The Next Generation of Smart Delivery Devices. Current Drug Metabolism, Volume 13, Number 1, January 2012, pp. 42-49(8). PubMed

2011

L. Nguyen, A. Kudva, N. Saxena and K. Roy. Engineering articular cartilage with spatially varying matrix composition and mechanical properties from a single stem cell population using a multi- layered hydrogel. Biomaterials. 2011 Oct; 32(29):6946-52. doi: 10.1016/j.biomaterials.2011.06.014. PubMed
A. Singh, H. Qin, I. Fernandez, J. Wei, J. Lin, L. W. Kwak and K. Roy. An injectable synthetic immune-priming center mediates efficient T-cell class switching and T-helper 1 response against B cell lymphoma. Journal of Controlled Release. 2011 Oct;155(2):184-92 doi: 10.1016/j.jconrel.2011.06.008. PubMed
M Caldorera-Moore, MK Kang, Z Moore, V Singh, SV Sreenivasan, L Shi, R Huang and K Roy. Swelling behavior of nanoscale, shape- and size-specific, hydrogel particles fabricated using imprint lithography. Soft Matter. 2011; 7:2879-2887. RSC
J Lin, I Fernandez, K Roy. Development of Feeder-Free Culture Systems for Generation of ckit+sca1+ Progenitors from Mouse iPS Cells. Stem Cell Rev. 2011 Sep;7(3):736-47. doi: 10.1007/s12015-010-9215-5. (J Lin and I Fernandez contributed equally to this work). PubMed

2010

K Fridley, I Fernandez, M-T A Li, RB Kettlewell, K Roy. Unique Differentiation Profile of Mouse Embryonic Stem Cells in Rotary and Stirred Tank Bioreactors. Tissue Engineering Part A. 2010 Nov;16(11):3285-98. doi: 10.1089/ten.TEA.2010.0166. PubMed
B Ghosn, A Singh, M Li, AV Vlassov, C Burnett, N Puri, K Roy. Efficient gene silencing in lungs and liver using imidazole-modified chitosan as a nanocarrier for small interfering RNA. Oligonucleotides.2010 Jun;20(3):163-72. doi: 10.1089/oli.2010.0235. PubMed
J Lin, H Nie, PW Tucker, K Roy. Controlled Major Histocompatibility Complex-T Cell Receptor Signaling Allows Efficient Generation of Functional, Antigen-Specific CD8(+) T Cells from Embryonic Stem Cells and Thymic Progenitors. Tissue engineering Part A. 2010 Sep;16(9):2709-20. doi: 10.1089/ten.TEA.2009.0707. PubMed
M Caldorera-Moore, N Guimard, L Shi, K Roy. Designer nanoparticles: incorporating size, shape and triggered release into nanoscale drug carriers. Expert Opin Drug Deliv. 2010 Apr;7(4):479-95. doi: 10.1517/17425240903579971. PubMed
I Kadiyala, Y Loo, K Roy. J Rice, KW Leong. Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes. Eur J Pharm Sci. 2010 Jan 31;39(1-3):103-9. doi: 10.1016/j.ejps.2009.11.002. PubMed
B Ghosn, AL van de Ven, J Tam, A Gillenwater, KV Sokolov, R Richards-Kortum, K Roy. Efficient mucosal delivery of optical contrast agents using imidazole-modified chitosan. J Biomed Opt. 2010 Jan-Feb;15(1):015003. doi: 10.1117/1.3309739. PubMed

2009

A Singh, S Suri, K Roy. In-situ crosslinking hydrogels for combinatorial delivery of chemokines and siRNA-DNA carrying microparticles to dendritic cells. Biomaterials. 2009 Oct;30(28):5187-200. doi: 10.1016/j.biomaterials.2009.06.001. PubMed

2008

A. Singh, H. Nie, B. Ghosn, H. Qin, L. W. Kwak, K. Roy. Efficient modulation of T cell response by dual-mode, single carrier delivery of cytokine-targeted siRNA and DNA vaccine to antigen presenting cells. Molecular Therapy. 2008 Dec;16(12):2011-21. doi: 10.1038/mt.2008.206. PubMed
E. Dawson, G. Mapili, K. Erickson, S. Taqvi and K. Roy. Biomaterials for Stem Cell Differentiation. Adv Drug Delivery Review. 2008 Jan 14;60(2):215-28. PubMed
B. Ghosn, S. Kasturi and K. Roy. Enhancing Polysaccharide-mediated Delivery of Nucleic Acids Through Functionalization with Secondary and Tertiary Amines. Current Topics in Medicinal Chemistry. 2008;8(4):331-40. PubMed
L.C. Glangchai, M.C. Moore, L. Shi and K. Roy. Nanoimprint Lithography Based Fabrication of Shape-specific, Enzymatically-Triggered Smart Nanoparticles. Journal of Controlled Release. 2008 Feb 11;125(3):263-72. PubMed

2007

L.H. Han, G. Mapili, S. Chen, and K. Roy. Projection micro-printing of 3-dimensional scaffolds for tissue engineering. Journal of Manufacturing Science and Engineering, 2007
L. Brannon-Peppas, B. Ghosn, K. Roy, K. Cornetta. Encapsulation of nucleic acids and opportunities for cancer treatment. Pharm Res. 2007 Apr;24(4):618-27. PubMed

2006

H. Liu, J. Lin and K. Roy. Effect of 3D scaffold and dynamic culture condition on the global gene expression profile of mouse embryonic stem cells. Biomaterials. 2006 Dec;27(36):5978-89. PubMed
S. Taqvi and K. Roy. Influence of scaffold physical properties and stromal cell co-culture on hematopoietic differentiation of mouse embryonic stem cells. Biomaterials 2006 Dec; 27(36):6024-31. PubMed
S. Taqvi, L. Dixit and K. Roy. Biomaterial-based notch signaling for the differentiation of hematopoietic stem cells into T cells. Biomed Mater Res A. 2006 Dec 1;79(3):689-97. PubMed
S. P. Kasturi, H. Qin, K. S. Thomson, S. El-Bereir, S.-C. Cha, S. Neelapu, L. W. Kwak and K. Roy. Prophylactic anti-tumor effects in a B cell lymphoma model with DNA vaccines delivered on polyethylenimine (PEI) functionalized PLGA microparticles. J Control Release. 2006 Jul 20;113(3):261-70. PubMed
Y. Lu, G. Mapili, G Suhali, S. Chen and K. Roy. A digital micro-mirror based device for the fabrication of spatially patterned tissue engineering scaffolds. J Biomed Mater Res A. 2006 May;77(2):396-405. PubMed

2005

S. Kasturi, K. Sachaphibulkij and K. Roy. Covalent-conjugation of polyethyeleneimine on biodegradable polymer microparticles for delivery of plasmid DNA vaccines, Biomaterials. 2005 Nov; 26(32):6375-85. PubMed
G. Mapili, Y. Lu, S. Chen and K. Roy. Laser-layered microfabrication of spatially patterned functionalized tissue-engineering scaffolds, J Biomed Mater Res B Appl Biomater. 2005 Nov;75(2):414-24. PubMed
H. Liu and K. Roy. Biomimetic 3D Cultures Significantly Increases Hematopoietic Differentiation Efficacy of Embryonic Stem Cells. Tissue Engineering, 2005 Jan-Feb;11 (1-2), 319-330. PubMed

2004 and earlier

H. Gu and K. Roy. Topical permeation enhancers significantly increase delivery of polymer micro and nanoparticles to epidermal Langerhans’ cells. Journal of Drug Delivery Science & Technology, 2004;14 (4) 265-273.
M. Follen, F.L. Meyskens, R.D. Alvarez, J.L. Walker, M.C. Bell, K.A. Storhz, J. Sastry, K. Roy. Richards-Kortum R, Corneilson TL. Cervical cancer chemoprevention, vaccines, and surrogate end point biomarkers. Cancer. 2003 Nov;98(9 Suppl): 2044-51. PubMed
K. Roy, D. Wang, M.L Hedley, S.P. Barman. Gene delivery with in-situ crosslinking polymer networks generates long-term systemic protein expression. Molecular Therapy. 2003;7(3):401-8. PubMed
U. McKeever, S. Barman, T. Hao, P. Chambers, S. Song, L. Lunsford, Y. Hsu, K. Roy, M.L. Hedley. Protective immune responses elicited in mice by immunization with formulations of poly(lactide-co-glycolide) microparticles. Vaccine 2002;22-20(11-12):1524-153. PubMed
H.Q. Mao, K. Roy, V.L. Truong-Le, K.Y. Lin, K.A. Janes, Y. Wang, J.T. August, and K.W. Leong. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J. Controlled Release, 70, 399-421 (2001). PubMed
K. Roy, H.Q. Mao, S.K. Huang, K. W. Leong. Oral gene delivery with DNA-chitosan nanoparticles generates immunologic protection in a murine model of peanut allergy. Nature Medicine, 5 (4) 387-391 (1999). PubMed
K.W. Leong, H.Q. Mao, V.L. Truong-Le, K. Roy, S.M. Walsh and J.T. August. DNA nanospheres as non-viral gene delivery vehicles. J. Controlled Release, 53 (1): 183-193 (1998). PubMed
D.R. Ingrams, J.K. Dhingra, K. Roy, D.F. Perrault Jr., I.D. Bottrill, S. Kabani, E.E. Rebeiz, M.M. Pankratov, S.M. Shapshay, R. Manoharan, I. Itzkan, M.S. Feld. Autofluorescence characteristics of Oral Mucosa. Head and Neck 19 (1): 27-32 (1997). PubMed