Welcome to the Integrative Systems Biology Lab!

The Integrative Systems Biology Lab, directed by Dr. Denis Tsygankov, focuses on integrating experimental and computational methods (involving modeling, simulations, and novel computer vision techniques) to gain a systems-level understanding of complex biological processes. The emphasis is made on biomechanical aspects of physiological phenomena across scales from molecules to cells to tissues.
 Lab News:
April 2024: Linjun secured Summer Research Funding from the MSBINF program.
April 2024: Jorik became a fellow of the NSF Graduate Research Fellowship Program (GRFP).
March 2024: Jorik has received G.D. Jain Outstanding Senior in Biomedical Engineering Award.
January 2024: Our collaborative septin ring paper got featured on the cover of Science Advances.
December 2023: Jorik has received Spring 2024 President’s Undergraduate Research Salary Award (PURA).
November 2023: Linjun has been granted GRA support by the M.S. Bioinformatics program.
November 2023: Our collaborative paper on dynein-powered cell locomotion has been featured as a Frontispiece in Advanced Science.
October 2023: Jorik has received President’s Undergraduate Research (PURA) Travel Award to attend 2023 International Mechanical Engineering Congress & Exposition, where he took First Place in the Undergraduate Research and Design Expo Student Poster Competition.
September 2023: Jorik has received Best Poster Presentation Award at the 3rd Nakatani RIES Symposium.
June 2023: Siarhei published his second first-author paper on Modeling Cell Ruffling in Cells.
April 2023: Siarhei successfully defended his PhD Dissertation and became a Doctor of Philosophy in Bioinformatics.
February 2023: Jorik has been accepted to the Nakatani Research & International Experience for Students Program and will do summer research in Japan with Dr. Taiji Adachi from Kyoto University.
December 2021: Asher has been awarded Alfred H. Gibeling Family Research Fund for his project on the role of PYGO1 in Cerebral Cavernous Malformation.
September 2021: Siarhei published his first first-author paper on Wave Domains in Scientific Reports.
September 2021: Dr. Tsygankov won gold medal in Atlanta Summer International Open IBJJF Jiu-Jitsu Championship (Master 2/White/Ultra-Heavy).
August 2021: The NIH has awarded Dr. Tsygankov an R21 grant for his project, “Patterns of Aging and the Role of Biomarkers in Senescence.”
April 2021: Asher has received Summer 2021 President’s Undergraduate Research Award (PURA) to investigate the role DAG1 and PALS1 in the development of Cerebral Cavernous Malformation.
February 2020: Dr. Tsygankov has won a Faculty Early Career Development (CAREER) Award from the National Science Foundation to study “Biomechanics of Collective Cell Migration.”
Full Story: NSF CAREER Award
February 2019: Olga and Anastasia published their big paper on Cerebral Cavernous Malformation in iScience.
June 2018: Dr. Tsygankov and Dr. Nie (School of Biology) have been awarded the Petit Institute Seed Grant to study Neural Crest Cell Migration.
July 2017: Dr. Tsygankov has received a 3-year grant from the Army Research Office to conduct a multi-scale study of collective cell behavior.
January 2017: Dr. Tsygankov and Dr. Qiu have received a Collaborative Grant in Cell Manufacturing from MC3M to develop a method for automated characterization of complex cell patterns.