Welcome to the Center for the Study of Systems Biology at Georgia Tech
What is Systems Biology?
Recognized by most experts in the field as the future of biology, Systems Biology seeks to understand how complex living systems interact with each other so that we can diagnose and treat disorders such as cancer. While past biological research has taught us much about how these individual biological units are structured and function, future biology will be focused on understanding how these units interact.
Vision of the Center for the Study of Systems Biology
With the completion of the sequencing of the human genome, the possibility exists to unlock the secrets of life and with such understanding, powerful new approaches to the treatment of disease will emerge. Read More →
Research Highlights
MOATAI-VIR: Hot Topic of the Day on 02/02/2012 on the Centers for Disease Control and Prevention, Public Health Genomics and Precision Health Knowledge Base webpage.
Astore, C, Zhou H, Jacob J, Skolnick J. 2021. MOATAI-VIR – an AI algorithm that predicts severe adverse events and molecular features for COVID-19’s complications. medRxiv 2021.01.29.21250712; doi: https://doi.org/10.1101/2021.01.29.21250712. PDF
Jeffrey Skolnick Receives Regents Recognition
Seven Georgia Tech Faculty Members Receive Regents Recognition – The University System of Georgia (USG) Board of Regents (BOR) appointed seven Georgia Tech faculty members Regents Professors, the highest academic recognition bestowed by the USG. The seven Regents Professors are:
- Marilyn Brown, Brook Byers Professor in Sustainable Manufacturing in the School of Public Policy
- Suresh Sitaraman, Morris M. Bryan Jr. Professor in Mechanical Engineering in the George W. Woodruff School of Mechanical Engineering
- Jeffrey Skolnick, Mary and Maisie Gibson Chair in Computational Systems Biology and GRA Eminent Scholar in the School of Biological Sciences
- Prasad Tetali, professor in the School of Mathematics and the School of Computer Science
- Vigor Yang, professor in the Daniel Guggenheim School of Aerospace Engineering
- Lisa Yaszek, professor in the School of Literature, Media, and Communication
- Ellen Zegura, Stephen Fleming Chair in the School of Computer Science
Origin of Life’s Handedness and Protein Biochemistry
Examine your hands. The right is a mirror image of the left. They look very similar, but you know they’re not when you try to put your left hand inside a right glove.
The molecules of life have a similar handedness. Proteins for example are like your left hand, made up of amino acids that are all left-handed. This phenomenon is called chirality. How chiral systems emerged is one of the key questions of origins-of-life research.
On the possible origin of protein homochirality, structure, and biochemical function
Living systems contain mainly chiral macromolecules, including proteins. How L-chiral proteins emerged from demi-chiral mixtures is unknown. Our simulations show that, compared to contemporary proteins, demi-chiral proteins have shorter regular secondary structures due to fewer internal hydrogen bonds, but similar global folds and small molecule binding sites. Demi-chiral proteins contain L-chiral substructures matching native active site geometries. Among the most frequently generated enzymes with native active site residues are ancient functions associated with metabolism and replication. This suggests that demi-chiral proteins could engage in early metabolism, creating the feedback loop for transcription and cell formation partly responsible for life’s emergence.
Jeffrey Skolnick, Mu Gao, and Hongyi Zhou win the NCATS ASPIRE Design Challenge 3: Predictive Algorithms for Translational Innovation in Pain, Opioid Use Disorder and Overdose
Time-resolved x-ray crystallography capture of a slow reaction tetrahydrofolate intermediate
Structural Dynamics – Editor’s Pick
Jeffrey Skolnick: 2018 Sigma Xi Sustained Research Award – Applying computational systems biology to improve human health
Georgia Tech has named Jeffrey Skolnick the recipient of the 2018 Sigma Xi Sustained Research Award. The award recognizes Skolnick’s exceptional sustained imagination and productivity in the fields of systems biology, computational biology, bioinformatics, cancer metabolomics, protein structure prediction and evolution, drug design, and simulations of cellular processes.
Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants
Highly Cited – Top Altmetric 2017 Articles