Hierarchically ranked comorbidities, comorbidity enriched MOA proteins, pathways and the top 20 drugs for each COVID-19 clinical manifestation from the SARS-CoV-2 interactome1 as input results.
| Clinical manifestation | Comorbidities | Comorbidity enriched MOA proteins | Pathways | Top pathways | CoMOAdrug drugs | CoVLS drugs |
|---|---|---|---|---|---|
| Neurologic | aseptic meningitis toxic encephalopathy Stiff-Person syndrome Bell's palsy relapsing-remitting multiple sclerosis encephalitis facial paralysis central nervous system lymphoma adrenoleukodystrophy chronic fatigue syndrome visual epilepsy inclusion body myositis myositis neuromuscular disease obsolete infantile epileptic encephalopathy meningitis Guillain-Barre syndrome survival motor neuron spinal muscular atrophy Werdnig-Hoffmann disease juvenile spinal muscular atrophy Cauda equina syndrome Alzheimer's disease 15 Alzheimer's disease 14 Alzheimer's disease 13 Alzheimer's disease 12 Alzheimer's disease 11 Alzheimer's disease 10 Alzheimer's disease 8 Alzheimer's disease 7 Alzheimer's disease 6 Alzheimer's disease 5 Alzheimer's disease 2 Leigh disease epilepsy Timothy syndrome generalized epilepsy with febrile seizures plus chronic meningitis Troyer syndrome hereditary spastic paraplegia 9B hereditary spastic paraplegia 9A hereditary spastic paraplegia 8 hereditary spastic paraplegia 77 hereditary spastic paraplegia 75 hereditary spastic paraplegia 73 hereditary spastic paraplegia 72 hereditary spastic paraplegia 7 hereditary spastic paraplegia 64 hereditary spastic paraplegia 63 hereditary spastic paraplegia 62 hereditary spastic paraplegia 61 hereditary spastic paraplegia 6 hereditary spastic paraplegia 5A hereditary spastic paraplegia 57 hereditary spastic paraplegia 56 hereditary spastic paraplegia 55 hereditary spastic paraplegia 54 hereditary spastic paraplegia 53 hereditary spastic paraplegia 49 hereditary spastic paraplegia 48 hereditary spastic paraplegia 46 hereditary spastic paraplegia 45 hereditary spastic paraplegia 44 hereditary spastic paraplegia 43 hereditary spastic paraplegia 42 hereditary spastic paraplegia 41 hereditary spastic paraplegia 4 hereditary spastic paraplegia 3A hereditary spastic paraplegia 39 hereditary spastic paraplegia 38 hereditary spastic paraplegia 37 hereditary spastic paraplegia 36 hereditary spastic paraplegia 35 hereditary spastic paraplegia 34 hereditary spastic paraplegia 32 hereditary spastic paraplegia 31 hereditary spastic paraplegia 30 hereditary spastic paraplegia 29 hereditary spastic paraplegia 28 hereditary spastic paraplegia 27 hereditary spastic paraplegia 26 hereditary spastic paraplegia 25 hereditary spastic paraplegia 24 hereditary spastic paraplegia 23 hereditary spastic paraplegia 2 hereditary spastic paraplegia 19 hereditary spastic paraplegia 18 hereditary spastic paraplegia 17 hereditary spastic paraplegia 16 hereditary spastic paraplegia 15 hereditary spastic paraplegia 14 hereditary spastic paraplegia 13 hereditary spastic paraplegia 12 hereditary spastic paraplegia 11 hereditary spastic paraplegia 10 alternating hemiplegia of childhood Aicardi-Goutieres syndrome congenital muscular dystrophy due to LMNA mutation congenital muscular dystrophy due to integrin alpha-7 deficiency muscular dystrophy-dystroglycanopathy type B6 muscular dystrophy-dystroglycanopathy type B5 congenital muscular dystrophy 1B rigid spine muscular dystrophy 1 megaconial type congenital muscular dystrophy muscular dystrophy-dystroglycanopathy autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 1H obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1A autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy type 2S obsolete autosomal recessive limb-girdle muscular dystrophy type 2R autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy autosomal dominant limb-girdle muscular dystrophy Charcot-Marie-Tooth disease X-linked recessive 4 Charcot-Marie-Tooth disease X-linked recessive 3 Charcot-Marie-Tooth disease X-linked recessive 5 Charcot-Marie-Tooth disease X-linked dominant 1 Charcot-Marie-Tooth disease X-linked recessive 2 Charcot-Marie-Tooth disease X-linked dominant 6 Charcot-Marie-Tooth disease dominant intermediate F Charcot-Marie-Tooth disease dominant intermediate E Charcot-Marie-Tooth disease recessive intermediate B Charcot-Marie-Tooth disease recessive intermediate D Charcot-Marie-Tooth disease dominant intermediate A Charcot-Marie-Tooth disease dominant intermediate D Charcot-Marie-Tooth disease dominant intermediate C Charcot-Marie-Tooth disease recessive intermediate C Charcot-Marie-Tooth disease dominant intermediate B Charcot-Marie-Tooth disease type 4G Charcot-Marie-Tooth disease type 4E Charcot-Marie-Tooth disease type 4B3 Charcot-Marie-Tooth disease type 4F Charcot-Marie-Tooth disease type 4H Charcot-Marie-Tooth disease type 4B1 Charcot-Marie-Tooth disease type 4B2 Charcot-Marie-Tooth disease type 4K Charcot-Marie-Tooth disease type 4D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease type 4J Charcot-Marie-Tooth disease type 4C Charcot-Marie-Tooth disease axonal type 2C Charcot-Marie-Tooth disease type 2B2 Charcot-Marie-Tooth disease axonal type 2N Charcot-Marie-Tooth disease axonal type 2O Charcot-Marie-Tooth disease axonal type 2L Charcot-Marie-Tooth disease axonal type 2U Charcot-Marie-Tooth disease axonal type 2Q Charcot-Marie-Tooth disease axonal type 2P Charcot-Marie-Tooth disease type 2Y Charcot-Marie-Tooth disease axonal type 2K Charcot-Marie-Tooth disease axonal type 2H Charcot-Marie-Tooth disease type 2E Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease axonal type 2F Charcot-Marie-Tooth disease type 2R Charcot-Marie-Tooth disease axonal type 2T Charcot-Marie-Tooth disease type 2B Charcot-Marie-Tooth disease type 2I Charcot-Marie-Tooth disease type 2J Charcot-Marie-Tooth disease type 2B1 Charcot-Marie-Tooth disease type 2A2A Charcot-Marie-Tooth disease type 2A1 Charcot-Marie-Tooth disease type 1E Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease type 1D Charcot-Marie-Tooth disease type 1F Charcot-Marie-Tooth disease type 1A periodic limb movement disorder spinocerebellar ataxia type 1 with axonal neuropathy neuropathy diplegia of upper limb peroneal nerve paralysis progressive bulbar palsy central pontine myelinolysis Brown-Sequard syndrome median neuropathy cranial nerve disease Schwartz-Jampel syndrome 1 agenesis of the corpus callosum with peripheral neuropathy olfactory nerve disease central core myopathy lateral medullary syndrome glossopharyngeal nerve disease hereditary sensory neuropathy type 1E hereditary sensory and autonomic neuropathy type 6 hereditary sensory and autonomic neuropathy type 7 vascular myelopathy nemaline myopathy thoracic outlet syndrome Landau-Kleffner syndrome chronic inflammatory demyelinating polyneuritis hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism hypomyelinating leukodystrophy 5 hypomyelinating leukodystrophy 11 Melkersson-Rosenthal syndrome Reye syndrome obsolete Alpers syndrome congenital central hypoventilation syndrome polyneuropathy due to drug alcoholic neuropathy multiple cranial nerve palsy Cayman type cerebellar ataxia hypoglossal nerve disease Grn-related frontotemporal lobar degeneration with Tdp43 inclusions mitochondrial complex II deficiency SPOAN syndrome Miller Fisher syndrome myoclonic cerebellar dyssynergia lesion of sciatic nerve common peroneal nerve lesion tarsal tunnel syndrome plantar nerve lesion Vagus nerve disease mitochondrial complex V (ATP synthase) deficiency nuclear type 2 radial nerve lesion ulnar nerve lesion photosensitive epilepsy distal myopathy oculopharyngeal muscular dystrophy Mast syndrome brain compression Balo concentric sclerosis familial hemiplegic migraine multiple sclerosis benign epilepsy with centrotemporal spikes cerebellar disease | C5orf52 L3HYPDH DNPEP SV2A RNPEP SV2B GATM ACYP1 FBXO31 PARS2 ACYP2 LANCL3 NHP2 CCL8 TXNDC12 ATXN3 RPL19 SEC31A GSTT1 GSTT2 | Glutathione conjugation | Metabolism Truncations of AMER1 destabilize the destruction complex | Disease APC truncation mutants have impaired AXIN binding | Disease AXIN missense mutants destabilize the destruction complex | Disease Signaling by APC mutants | Disease Signaling by GSK3beta mutants | Disease Signaling by AMER1 mutants | Disease Signaling by AXIN mutants | Disease Activation of kainate receptors upon glutamate binding | Neuronal system Signaling by CTNNB1 phospho-site mutants | Disease S33 mutants of beta-catenin aren't phosphorylated | Disease S45 mutants of beta-catenin aren't phosphorylated | Disease T41 mutants of beta-catenin aren't phosphorylated | Disease S37 mutants of beta-catenin aren't phosphorylated | Disease CRMPs in Sema3A signaling | Developmental biology Beta-catenin phosphorylation cascade | Signal transduction G beta:gamma signalling through BTK | Signal transduction G beta:gamma signalling through CDC42 | Signal transduction | Pomalidomide Tetrahydrofolic acid Vindesine Ifosfamide Cabazitaxel Prednisolone*$ Everolimus* Regorafenib Prasterone* Idarubicin Cyclophosphamide Gonadorelin Paclitaxel* Azacitidine Valaciclovir Lactulose* Codeine* Epirubicin Vincristine Drostanolone | Gadobutrol Amphetamine* Pipobroman Felbamate Nateglinide Ipratropium bromide Cilastatin Butabarbital Phenindione Gadoteridol Peramivir Seratrodast Hexylresorcinol Butalbital Mephentermine Piracetam* Pantethine Trihexyphenidyl* Levomethadyl Acetate Digoxin |
| Respiratory | severe acute respiratory syndrome viral pneumonia pleural disease lymphangioleiomyomatosis idiopathic pulmonary fibrosis adult respiratory distress syndrome pleuropneumonia interstitial lung disease bronchial disease silicosis avian influenza mediastinitis sphenoid sinusitis chronic sphenoidal sinusitis chronic maxillary sinusitis frontal sinusitis chronic frontal sinusitis diaphragm disease pneumoconiosis due to talc anthracosis anthracosilicosis byssinosis pneumoconiosis compensatory emphysema interstitial emphysema Streptococcus pneumonia Chlamydia pneumonia ethmoid sinusitis epiglottitis chronic ethmoiditis lipid pneumonia acute interstitial pneumonia desquamative interstitial pneumonia spontaneous tension pneumothorax respiratory system disease cryptogenic organizing pneumonia laryngotracheitis Mycoplasma pneumoniae pneumonia Klebsiella pneumonia adenoiditis cough variant asthma postinflammatory pulmonary fibrosis pulmonary alveolar proteinosis pulmonary hemosiderosis pulmonary alveolar microlithiasis adenoid hypertrophy chronic laryngitis acute laryngopharyngitis hemopneumothorax lung abscess | MYH8 MYH2 MYO19 MYO1H MYO7A MYO1B MYO5A MYO5B MYO5C MYO6 MYO16 TOP2A MYH13 MYH15 MYH9 MYO1C MYH14 MYO1D CEP112 GOLGA8R | Leishmania phagocytosis | Disease Parasite infection | Disease FCGR3A-mediated phagocytosis | Disease Regulation of actin dynamics for phagocytic cup formation | Immune system Sensory processing of sound by outer hair cells of the cochlea | Sensory perception RHO GTPases activate CIT | Signal transduction RHO GTPases Activate ROCKs | Signal transduction Sema4D induced cell migration and growth-cone collapse | Developmental biology Transcription of E2F targets under negative control by DREAM complex | Cell cycle Fcgamma receptor (FCGR) dependent phagocytosis | Immune system RHO GTPases activate PAKs | Signal transduction Sensory processing of sound by inner hair cells of the cochlea | Sensory perception Sema4D in semaphorin signaling | Developmental biology Translocation of SLC2A4 (GLUT4) to the plasma membrane | Vesicle-mediated transport EPHA-mediated growth cone collapse | Developmental biology Sensory processing of sound | Sensory perception G0 and Early G1 | Cell cycle | Prednisolone*$ Tetrahydrofolic acid Cabazitaxel Ifosfamide Vindesine Pomalidomide Amoxicillin*$ Acarbose Prednisone*$ Regorafenib Everolimus* Hydrocortisone*$ Paclitaxel* Idarubicin Cyclophosphamide Gonadorelin Lactulose Vincristine Pefloxacin Prasterone | Delafloxacin* Gatifloxacin Moxifloxacin*$ Perampanel Lomefloxacin Enoxacin Abemaciclib Pefloxacin Technetium Tc-99m pyrophosphate Sparfloxacin Liothyronine* Flibanserin Levofloxacin*$ Diatrizoate Propylthiouracil Rucaparib Ciprofloxacin* Gemifloxacin Amrubicin Calcium Phosphate |
| Hematologic | uveal cancer Fanconi anemia hemoglobinopathy primary immunodeficiency disease hematopoietic system disease paroxysmal nocturnal hemoglobinuria Diamond-Blackfan anemia bone marrow disease severe combined immunodeficiency MHC class II deficiency aplastic anemia thrombocytopenia myelofibrosis thalassemia anemia hemophagocytic lymphohistiocytosis hemoglobin C disease common variable immunodeficiency Wiskott-Aldrich syndrome polycythemia obsolete leukemoid reaction pancytopenia chronic granulomatous disease factor VIII deficiency neutropenia Chediak-Higashi syndrome histiocytosis sickle cell anemia leukopenia thymoma X-linked agammaglobulinemia von Willebrand's disease autoimmune lymphoproliferative syndrome DiGeorge syndrome congenital hemolytic anemia hypereosinophilic syndrome protein C deficiency protein S deficiency factor V deficiency factor VII deficiency alpha-2-plasmin inhibitor deficiency purpura fulminans antithrombin III deficiency | GMPR ASMTL METTL21B NTPCR AK4 AK2 OAS2 TUT1 RRM1 RAB35 HENMT1 METTL21A POLE2 POLE4 AK6 TREX1 TOP3B CMPK1 IDNK USB1 | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide* Ifosfamide* Tetrahydrofolic acid Cabazitaxel* Gonadorelin Azacitidine* Lactulose Prednisolone*$ Epirubicin* Idarubicin* Cyclophosphamide* Valaciclovir Everolimus* Vincristine* Fludarabine* Regorafenib* Vidarabine Prasterone Samarium (153Sm) lexidronam | Emtricitabine$ Lamivudine* Tetrahydrofolic acid Vindesine Decitabine*$ Cidofovir Capecitabine* Adefovir Dipivoxil Tenofovir$ disoproxil Famciclovir Azacitidine* Entecavir Sofosbuvir*$ Aciclovir* Gemcitabine* Vidarabine Abacavir Ganciclovir* Ticagrelor*$ Mipomersen |
| Endocrine | ovarian disease lysosomal storage disease hyperuricemia thyroid gland disease hypobetalipoproteinemia amyloidosis hematologic cancer Chediak-Higashi syndrome Sandhoff disease Tay-Sachs disease GM1 gangliosidosis adrenoleukodystrophy lipomatosis metachromatic leukodystrophy Wolman disease gangliosidosis Krabbe disease bilirubin metabolic disorder mucopolysaccharidosis III peroxisomal disease disease of metabolism lipid metabolism disorder ariboflavinosis beriberi pellagra pyridoxine deficiency anemia kwashiorkor insulinoma marasmus protein-energy malnutrition argininosuccinic aciduria rickets calcinosis | GMPR NTPCR AK4 AK2 RAB35 AK6 IDNK AK7 GUF1 URGCP EFTUD2 IFI44 GNL1 ARL13B GNL3 SMG9 ARL5A GIMAP8 IRGM ARL17B | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide Ifosfamide Tetrahydrofolic acid Cabazitaxel Gonadorelin* Lactulose* Azacitidine* Idarubicin Epirubicin Cyclophosphamide* Vincristine Prednisolone*$ Valaciclovir Everolimus* Prasterone Regorafenib* Vidarabine Fludarabine* Vinorelbine | Emtricitabine$ Lamivudine Tenofovir$ disoproxil Adefovir Dipivoxil Cidofovir Capecitabine* Decitabine$ Famciclovir Azacitidine* Sofosbuvir$ Tetrahydrofolic acid Vindesine Vidarabine Citric Acid Aciclovir Entecavir Abacavir Gemcitabine* Ticagrelor*$ Mipomersen |
| Ocular symptoms | neuroretinitis retinitis retinal artery occlusion anterior uveitis scleritis pars planitis keratitis panuveitis posterior uveitis intermediate uveitis external ear disease acute transudative otitis media chronic tubotympanic suppurative otitis media chronic atticoantral disease chronic purulent otitis media acute serous otitis media serous glue ear non-suppurative otitis media | MYH8 MYO7A MYO1H MYO5A MYO19 MYO5C MYO6 MYO5B MYO1B MYH2 MYO16 TOP2A MYO1C MYH13 MYH9 MYH15 MYH14 MYO1D NR3C2 NR4A3 | Nuclear Receptor transcription pathway | Gene expression (Transcription) Nuclear signaling by ERBB4 | Signal transduction Noncanonical activation of NOTCH3 | Signal transduction NOTCH4 Activation and Transmission of Signal to the Nucleus | Signal transduction Regulated proteolysis of p75NTR | Signal transduction Reduction of cytosolic Ca++ levels | Hemostasis Sodium/Calcium exchangers | Transport of small molecules SUMOylation of intracellular receptors | Metabolism of proteins NRIF signals cell death from the nucleus | Signal transduction Signaling by ERBB4 | Signal transduction Synthesis of very long-chain fatty acyl-CoAs | Metabolism | Prednisolone*$ Tetrahydrofolic acid Cabazitaxel Vindesine Ifosfamide* Pomalidomide Diflorasone Everolimus* Gonadorelin Idarubicin Prednisone*$ Cyclophosphamide* Paclitaxel* Lactulose Regorafenib* Vincristine* Prasterone Pravastatin* Hydrocortisone*$ Trifluridine | Diflorasone Delafloxacin Betamethasone* Besifloxacin* Gatifloxacin* Moxifloxacin*$ Perampanel Clocortolone Clobetasone Deflazacort Ulobetasol Lomefloxacin Enoxacin Fluticasone* furoate Mometasone*$ Alclometasone Triamcinolone* Desoximetasone Fluorometholone* Prednisolone*$ |
| Renal acute kidney failure injury | perineurioma Fanconi syndrome prostate disease bacterial vaginosis vasculogenic impotence oligospermia chronic kidney disease kidney cortex necrosis acute kidney tubular necrosis renal artery obstruction gliomatosis cerebri | RETSAT RDH14 RDH12 DHRS7 KCNA10 RDH13 FAM84B HRASLS5 RARRES1 RARRES3 RDH8 SLC8A3 NR4A3 ELOVL7 RDH11 ELOVL1 HRASLS2 ASMTL PLEKHG4 PLA2G16 | RAB geranylgeranylation | Metabolism of proteins | Pomalidomide* Vindesine Ifosfamide* Tetrahydrofolic acid Cabazitaxel* Everolimus* Regorafenib* Prednisolone*$ Idarubicin Cyclophosphamide* Prasterone Pravastatin* Paclitaxel* Codeine Gonadorelin Vincristine* Pyrazinamide Lactulose* Azacitidine* Valaciclovir | Citric* Acid Emtricitabine*$ Vindesine Norelgestromin Lamivudine* Calcidiol* Decitabine*$ Cidofovir* Levonorgestrel Capecitabine* Famciclovir Glimepiride* Azacitidine* Adefovir Dipivoxil Tenofovir*$ disoproxil Drostanolone Entecavir* Sofosbuvir*$ Aciclovir Vincristine* |
| Cardiovascular/arrhythmia | coronary stenosis brain infarction lymphatic system disease middle cerebral artery infarction atrioventricular block Wolff-Parkinson-White syndrome brain stem infarction coronary thrombosis intracranial arteriosclerosis pulmonary embolism and infarction intracranial thrombosis | GMPR ASMTL METTL21B TUBE1 NTPCR METTL21A AK4 AK2 TUBD1 TUT1 OAS2 RRM1 SEPT10 METTL13 RAB35 HENMT1 NDUFAF5 IDNK AK6 TFB1M | RAB geranylgeranylation | Metabolism of proteins Protein methylation | Metabolism of proteins | Pomalidomide Vindesine Ifosfamide Tetrahydrofolic acid Cabazitaxel Everolimus* Gonadorelin Azacitidine Lactulose Idarubicin Cyclophosphamide* Prednisolone*$ Epirubicin Valaciclovir Vincristine Fludarabine* Prasterone Regorafenib Vidarabine Samarium (153Sm) lexidronam | Emtricitabine*$ Lamivudine* Vindesine Decitabine$ Cidofovir Capecitabine Adefovir Dipivoxil Tenofovir$ disoproxil Famciclovir Azacitidine Abacavir* Entecavir Sofosbuvir$ Aciclovir Gemcitabine Ganciclovir Ticagrelor*$ Vidarabine Vincristine Mipomersen |
| Sepsis | hepatitis A hepatitis E hantavirus pulmonary syndrome genital herpes hepatitis D respiratory syncytial virus infectious disease X-linked hyper IgM syndrome hepatitis B | ASMTL TUBE1 TUBD1 METTL21B GMPR NTPCR RRM1 TUT1 OAS2 AK4 AK2 METTL21A POLE2 POLE4 USB1 TREX1 TOP3B CMPK1 RAB35 AK6 | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide Ifosfamide Tetrahydrofolic acid Cabazitaxel Lactulose* Gonadorelin Epirubicin Azacitidine Idarubicin Cyclophosphamide Vincristine Valaciclovir Regorafenib Vidarabine Fludarabine Prednisolone*$ Everolimus* Vinorelbine Paclitaxel | Emtricitabine*$ Lamivudine* Vindesine Cidofovir* Decitabine$ Capecitabine Adefovir Dipivoxil Tenofovir*$ disoproxil Famciclovir Azacitidine Entecavir* Sofosbuvir$ Aciclovir Vidarabine Gemcitabine Ganciclovir* Mipomersen Tenofovir$ alafenamide Penciclovir Zidovudine* |
| Hepatocellular injury/Acute hepatitis/Liver failure | biliary tract disease exocrine pancreatic insufficiency cholestasis pancreas disease gastrointestinal system disease liver cirrhosis intrahepatic cholestasis | ASMTL DGUOK TUBE1 NDUFA10 TK2 TUBD1 TAF6 OAS2 TUT1 RRM1 METTL21B CMPK1 METTL21A TOP3B TREX1 NTPCR METTL17 USB1 AK4 AK2 | RAB geranylgeranylation | Metabolism of proteins | Cabazitaxel Lactulose Ifosfamide Vindesine Gonadorelin Paclitaxel Idarubicin Tetrahydrofolic acid Vincristine Cyclophosphamide Vinorelbine Erlotinib Pomalidomide Prasterone Triptorelin Cisplatin Tibolone Betazole Docetaxel Mitoxantrone | Emtricitabine$ Lamivudine Vindesine Cidofovir Decitabine$ Famciclovir Capecitabine Entecavir Azacitidine Tenofovir$ disoproxil Adefovir Dipivoxil Doxofylline Sofosbuvir$ Aciclovir Zidovudine Penciclovir Caffeine Tegafur Gemcitabine Tenofovir$ alafenamide |
| Cerebral ischemia/infarction | brain infarction lymphatic system disease middle cerebral artery infarction brain stem infarction intracranial arteriosclerosis intracranial thrombosis | RPS19 POLR3F TCOF1 PCSK5 CUTA PXDNL SQLE | Activation of gene expression by SREBF (SREBP) | Metabolism Expression and Processing of Neurotrophins | Signal transduction NGF processing | Signal transduction Regulation of cholesterol biosynthesis by SREBP (SREBF) | Metabolism RNA Polymerase III Chain Elongation | Gene expression (Transcription) RNA Polymerase III Transcription Termination | Gene expression (Transcription) | Pomalidomide Ifosfamide Everolimus Cabazitaxel Vindesine Prednisolone$ Tetrahydrofolic acid Pravastatin Prasterone Cyclophosphamide Regorafenib Estriol Methylscopolamine bromide Medrogestone Oxytetracycline Gonadorelin Paclitaxel Trandolapril Idarubicin Gallium citrate Ga 67 | Phenyl salicylate Emtricitabine$ Selexipag Lamivudine Decitabine$ Cidofovir Famciclovir Vindesine Capecitabine Tenofovir$ disoproxil Azacitidine Adefovir Dipivoxil Entecavir Sofosbuvir$ Tenofovir$ alafenamide Doxofylline Zidovudine Aciclovir Amphetamine Penciclovir |
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