Hierarchically ranked comorbidities, comorbidity enriched MOA proteins, pathways and the top 20 drugs for each COVID-19 clinical manifestation from the SARS-CoV-2 interactome1 as input results.
| Clinical manifestation | Comorbidities | Comorbidity enriched MOA proteins | Pathways | Top pathways | CoMOAdrug drugs | CoVLS drugs |
|---|---|---|---|---|---|
| Neurologic | aseptic meningitis toxic encephalopathy Stiff-Person syndrome Bell's palsy relapsing-remitting multiple sclerosis encephalitis facial paralysis central nervous system lymphoma adrenoleukodystrophy chronic fatigue syndrome visual epilepsy inclusion body myositis myositis neuromuscular disease obsolete infantile epileptic encephalopathy meningitis Guillain-Barre syndrome survival motor neuron spinal muscular atrophy Werdnig-Hoffmann disease juvenile spinal muscular atrophy Cauda equina syndrome Alzheimer's disease 15 Alzheimer's disease 14 Alzheimer's disease 13 Alzheimer's disease 12 Alzheimer's disease 11 Alzheimer's disease 10 Alzheimer's disease 8 Alzheimer's disease 7 Alzheimer's disease 6 Alzheimer's disease 5 Alzheimer's disease 2 Leigh disease epilepsy Timothy syndrome generalized epilepsy with febrile seizures plus chronic meningitis Troyer syndrome hereditary spastic paraplegia 9B hereditary spastic paraplegia 9A hereditary spastic paraplegia 8 hereditary spastic paraplegia 77 hereditary spastic paraplegia 75 hereditary spastic paraplegia 73 hereditary spastic paraplegia 72 hereditary spastic paraplegia 7 hereditary spastic paraplegia 64 hereditary spastic paraplegia 63 hereditary spastic paraplegia 62 hereditary spastic paraplegia 61 hereditary spastic paraplegia 6 hereditary spastic paraplegia 5A hereditary spastic paraplegia 57 hereditary spastic paraplegia 56 hereditary spastic paraplegia 55 hereditary spastic paraplegia 54 hereditary spastic paraplegia 53 hereditary spastic paraplegia 49 hereditary spastic paraplegia 48 hereditary spastic paraplegia 46 hereditary spastic paraplegia 45 hereditary spastic paraplegia 44 hereditary spastic paraplegia 43 hereditary spastic paraplegia 42 hereditary spastic paraplegia 41 hereditary spastic paraplegia 4 hereditary spastic paraplegia 3A hereditary spastic paraplegia 39 hereditary spastic paraplegia 38 hereditary spastic paraplegia 37 hereditary spastic paraplegia 36 hereditary spastic paraplegia 35 hereditary spastic paraplegia 34 hereditary spastic paraplegia 32 hereditary spastic paraplegia 31 hereditary spastic paraplegia 30 hereditary spastic paraplegia 29 hereditary spastic paraplegia 28 hereditary spastic paraplegia 27 hereditary spastic paraplegia 26 hereditary spastic paraplegia 25 hereditary spastic paraplegia 24 hereditary spastic paraplegia 23 hereditary spastic paraplegia 2 hereditary spastic paraplegia 19 hereditary spastic paraplegia 18 hereditary spastic paraplegia 17 hereditary spastic paraplegia 16 hereditary spastic paraplegia 15 hereditary spastic paraplegia 14 hereditary spastic paraplegia 13 hereditary spastic paraplegia 12 hereditary spastic paraplegia 11 hereditary spastic paraplegia 10 alternating hemiplegia of childhood Aicardi-Goutieres syndrome congenital muscular dystrophy due to LMNA mutation congenital muscular dystrophy due to integrin alpha-7 deficiency muscular dystrophy-dystroglycanopathy type B6 muscular dystrophy-dystroglycanopathy type B5 congenital muscular dystrophy 1B rigid spine muscular dystrophy 1 megaconial type congenital muscular dystrophy muscular dystrophy-dystroglycanopathy autosomal dominant limb-girdle muscular dystrophy type 3 autosomal dominant limb-girdle muscular dystrophy type 1 autosomal dominant limb-girdle muscular dystrophy type 2 autosomal dominant limb-girdle muscular dystrophy type 1H obsolete autosomal dominant limb-girdle muscular dystrophy type 1C obsolete autosomal dominant limb-girdle muscular dystrophy type 1B obsolete autosomal dominant limb-girdle muscular dystrophy type 1A autosomal recessive limb-girdle muscular dystrophy type 2I autosomal recessive limb-girdle muscular dystrophy type 2N autosomal recessive limb-girdle muscular dystrophy type 2K autosomal recessive limb-girdle muscular dystrophy type 2M autosomal recessive limb-girdle muscular dystrophy type 2U autosomal recessive limb-girdle muscular dystrophy type 2T autosomal recessive limb-girdle muscular dystrophy type 2P autosomal recessive limb-girdle muscular dystrophy type 2O autosomal recessive limb-girdle muscular dystrophy type 2Y autosomal recessive limb-girdle muscular dystrophy type 2S obsolete autosomal recessive limb-girdle muscular dystrophy type 2R autosomal recessive limb-girdle muscular dystrophy type 2Q autosomal recessive limb-girdle muscular dystrophy type 2L autosomal recessive limb-girdle muscular dystrophy type 2J autosomal recessive limb-girdle muscular dystrophy type 2H autosomal recessive limb-girdle muscular dystrophy type 2G autosomal recessive limb-girdle muscular dystrophy type 2F autosomal recessive limb-girdle muscular dystrophy type 2E autosomal recessive limb-girdle muscular dystrophy type 2D autosomal recessive limb-girdle muscular dystrophy type 2C autosomal recessive limb-girdle muscular dystrophy type 2B autosomal recessive limb-girdle muscular dystrophy type 2A autosomal recessive limb-girdle muscular dystrophy autosomal dominant limb-girdle muscular dystrophy Charcot-Marie-Tooth disease X-linked recessive 4 Charcot-Marie-Tooth disease X-linked recessive 3 Charcot-Marie-Tooth disease X-linked recessive 5 Charcot-Marie-Tooth disease X-linked dominant 1 Charcot-Marie-Tooth disease X-linked recessive 2 Charcot-Marie-Tooth disease X-linked dominant 6 Charcot-Marie-Tooth disease dominant intermediate F Charcot-Marie-Tooth disease dominant intermediate E Charcot-Marie-Tooth disease recessive intermediate B Charcot-Marie-Tooth disease recessive intermediate D Charcot-Marie-Tooth disease dominant intermediate A Charcot-Marie-Tooth disease dominant intermediate D Charcot-Marie-Tooth disease dominant intermediate C Charcot-Marie-Tooth disease recessive intermediate C Charcot-Marie-Tooth disease dominant intermediate B Charcot-Marie-Tooth disease type 4G Charcot-Marie-Tooth disease type 4E Charcot-Marie-Tooth disease type 4B3 Charcot-Marie-Tooth disease type 4F Charcot-Marie-Tooth disease type 4H Charcot-Marie-Tooth disease type 4B1 Charcot-Marie-Tooth disease type 4B2 Charcot-Marie-Tooth disease type 4K Charcot-Marie-Tooth disease type 4D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease type 4J Charcot-Marie-Tooth disease type 4C Charcot-Marie-Tooth disease axonal type 2C Charcot-Marie-Tooth disease type 2B2 Charcot-Marie-Tooth disease axonal type 2N Charcot-Marie-Tooth disease axonal type 2O Charcot-Marie-Tooth disease axonal type 2L Charcot-Marie-Tooth disease axonal type 2U Charcot-Marie-Tooth disease axonal type 2Q Charcot-Marie-Tooth disease axonal type 2P Charcot-Marie-Tooth disease type 2Y Charcot-Marie-Tooth disease axonal type 2K Charcot-Marie-Tooth disease axonal type 2H Charcot-Marie-Tooth disease type 2E Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease axonal type 2F Charcot-Marie-Tooth disease type 2R Charcot-Marie-Tooth disease axonal type 2T Charcot-Marie-Tooth disease type 2B Charcot-Marie-Tooth disease type 2I Charcot-Marie-Tooth disease type 2J Charcot-Marie-Tooth disease type 2B1 Charcot-Marie-Tooth disease type 2A2A Charcot-Marie-Tooth disease type 2A1 Charcot-Marie-Tooth disease type 1E Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease type 1D Charcot-Marie-Tooth disease type 1F Charcot-Marie-Tooth disease type 1A periodic limb movement disorder spinocerebellar ataxia type 1 with axonal neuropathy neuropathy diplegia of upper limb peroneal nerve paralysis progressive bulbar palsy central pontine myelinolysis Brown-Sequard syndrome median neuropathy cranial nerve disease Schwartz-Jampel syndrome 1 agenesis of the corpus callosum with peripheral neuropathy olfactory nerve disease central core myopathy lateral medullary syndrome glossopharyngeal nerve disease hereditary sensory neuropathy type 1E hereditary sensory and autonomic neuropathy type 6 hereditary sensory and autonomic neuropathy type 7 vascular myelopathy nemaline myopathy thoracic outlet syndrome Landau-Kleffner syndrome chronic inflammatory demyelinating polyneuritis hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism hypomyelinating leukodystrophy 5 hypomyelinating leukodystrophy 11 Melkersson-Rosenthal syndrome Reye syndrome obsolete Alpers syndrome congenital central hypoventilation syndrome polyneuropathy due to drug alcoholic neuropathy multiple cranial nerve palsy Cayman type cerebellar ataxia hypoglossal nerve disease Grn-related frontotemporal lobar degeneration with Tdp43 inclusions mitochondrial complex II deficiency SPOAN syndrome Miller Fisher syndrome myoclonic cerebellar dyssynergia lesion of sciatic nerve common peroneal nerve lesion tarsal tunnel syndrome plantar nerve lesion Vagus nerve disease mitochondrial complex V (ATP synthase) deficiency nuclear type 2 radial nerve lesion ulnar nerve lesion photosensitive epilepsy distal myopathy oculopharyngeal muscular dystrophy Mast syndrome brain compression Balo concentric sclerosis familial hemiplegic migraine multiple sclerosis benign epilepsy with centrotemporal spikes cerebellar disease | C5orf52 L3HYPDH DNPEP SV2A RNPEP SV2B GATM ACYP1 FBXO31 PARS2 ACYP2 LANCL3 NHP2 CCL8 TXNDC12 ATXN3 RPL19 SEC31A GSTT1 GSTT2 | Glutathione conjugation | Metabolism Truncations of AMER1 destabilize the destruction complex | Disease APC truncation mutants have impaired AXIN binding | Disease AXIN missense mutants destabilize the destruction complex | Disease Signaling by APC mutants | Disease Signaling by GSK3beta mutants | Disease Signaling by AMER1 mutants | Disease Signaling by AXIN mutants | Disease Activation of kainate receptors upon glutamate binding | Neuronal system Signaling by CTNNB1 phospho-site mutants | Disease S33 mutants of beta-catenin aren't phosphorylated | Disease S45 mutants of beta-catenin aren't phosphorylated | Disease T41 mutants of beta-catenin aren't phosphorylated | Disease S37 mutants of beta-catenin aren't phosphorylated | Disease CRMPs in Sema3A signaling | Developmental biology Beta-catenin phosphorylation cascade | Signal transduction G beta:gamma signalling through BTK | Signal transduction G beta:gamma signalling through CDC42 | Signal transduction | Pomalidomide Tetrahydrofolic acid Vindesine Ifosfamide Cabazitaxel Prednisolone*$ Everolimus* Regorafenib Prasterone* Idarubicin Cyclophosphamide Gonadorelin Paclitaxel* Azacitidine Valaciclovir Lactulose* Codeine* Epirubicin Vincristine Drostanolone | Gadobutrol Amphetamine* Pipobroman Felbamate Nateglinide Ipratropium bromide Cilastatin Butabarbital Phenindione Gadoteridol Peramivir Seratrodast Hexylresorcinol Butalbital Mephentermine Piracetam* Pantethine Trihexyphenidyl* Levomethadyl Acetate Digoxin |
| Respiratory | severe acute respiratory syndrome viral pneumonia pleural disease lymphangioleiomyomatosis idiopathic pulmonary fibrosis adult respiratory distress syndrome pleuropneumonia interstitial lung disease bronchial disease silicosis avian influenza mediastinitis sphenoid sinusitis chronic sphenoidal sinusitis chronic maxillary sinusitis frontal sinusitis chronic frontal sinusitis diaphragm disease pneumoconiosis due to talc anthracosis anthracosilicosis byssinosis pneumoconiosis compensatory emphysema interstitial emphysema Streptococcus pneumonia Chlamydia pneumonia ethmoid sinusitis epiglottitis chronic ethmoiditis lipid pneumonia acute interstitial pneumonia desquamative interstitial pneumonia spontaneous tension pneumothorax respiratory system disease cryptogenic organizing pneumonia laryngotracheitis Mycoplasma pneumoniae pneumonia Klebsiella pneumonia adenoiditis cough variant asthma postinflammatory pulmonary fibrosis pulmonary alveolar proteinosis pulmonary hemosiderosis pulmonary alveolar microlithiasis adenoid hypertrophy chronic laryngitis acute laryngopharyngitis hemopneumothorax lung abscess | MYH8 MYH2 MYO19 MYO1H MYO7A MYO1B MYO5A MYO5B MYO5C MYO6 MYO16 TOP2A MYH13 MYH15 MYH9 MYO1C MYH14 MYO1D CEP112 GOLGA8R | Leishmania phagocytosis | Disease Parasite infection | Disease FCGR3A-mediated phagocytosis | Disease Regulation of actin dynamics for phagocytic cup formation | Immune system Sensory processing of sound by outer hair cells of the cochlea | Sensory perception RHO GTPases activate CIT | Signal transduction RHO GTPases Activate ROCKs | Signal transduction Sema4D induced cell migration and growth-cone collapse | Developmental biology Transcription of E2F targets under negative control by DREAM complex | Cell cycle Fcgamma receptor (FCGR) dependent phagocytosis | Immune system RHO GTPases activate PAKs | Signal transduction Sensory processing of sound by inner hair cells of the cochlea | Sensory perception Sema4D in semaphorin signaling | Developmental biology Translocation of SLC2A4 (GLUT4) to the plasma membrane | Vesicle-mediated transport EPHA-mediated growth cone collapse | Developmental biology Sensory processing of sound | Sensory perception G0 and Early G1 | Cell cycle | Prednisolone*$ Tetrahydrofolic acid Cabazitaxel Ifosfamide Vindesine Pomalidomide Amoxicillin*$ Acarbose Prednisone*$ Regorafenib Everolimus* Hydrocortisone*$ Paclitaxel* Idarubicin Cyclophosphamide Gonadorelin Lactulose Vincristine Pefloxacin Prasterone | Delafloxacin* Gatifloxacin Moxifloxacin*$ Perampanel Lomefloxacin Enoxacin Abemaciclib Pefloxacin Technetium Tc-99m pyrophosphate Sparfloxacin Liothyronine* Flibanserin Levofloxacin*$ Diatrizoate Propylthiouracil Rucaparib Ciprofloxacin* Gemifloxacin Amrubicin Calcium Phosphate |
| Hematologic | uveal cancer Fanconi anemia hemoglobinopathy primary immunodeficiency disease hematopoietic system disease paroxysmal nocturnal hemoglobinuria Diamond-Blackfan anemia bone marrow disease severe combined immunodeficiency MHC class II deficiency aplastic anemia thrombocytopenia myelofibrosis thalassemia anemia hemophagocytic lymphohistiocytosis hemoglobin C disease common variable immunodeficiency Wiskott-Aldrich syndrome polycythemia obsolete leukemoid reaction pancytopenia chronic granulomatous disease factor VIII deficiency neutropenia Chediak-Higashi syndrome histiocytosis sickle cell anemia leukopenia thymoma X-linked agammaglobulinemia von Willebrand's disease autoimmune lymphoproliferative syndrome DiGeorge syndrome congenital hemolytic anemia hypereosinophilic syndrome protein C deficiency protein S deficiency factor V deficiency factor VII deficiency alpha-2-plasmin inhibitor deficiency purpura fulminans antithrombin III deficiency | GMPR ASMTL METTL21B NTPCR AK4 AK2 OAS2 TUT1 RRM1 RAB35 HENMT1 METTL21A POLE2 POLE4 AK6 TREX1 TOP3B CMPK1 IDNK USB1 | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide* Ifosfamide* Tetrahydrofolic acid Cabazitaxel* Gonadorelin Azacitidine* Lactulose Prednisolone*$ Epirubicin* Idarubicin* Cyclophosphamide* Valaciclovir Everolimus* Vincristine* Fludarabine* Regorafenib* Vidarabine Prasterone Samarium (153Sm) lexidronam | Emtricitabine$ Lamivudine* Tetrahydrofolic acid Vindesine Decitabine*$ Cidofovir Capecitabine* Adefovir Dipivoxil Tenofovir$ disoproxil Famciclovir Azacitidine* Entecavir Sofosbuvir*$ Aciclovir* Gemcitabine* Vidarabine Abacavir Ganciclovir* Ticagrelor*$ Mipomersen |
| Endocrine | ovarian disease lysosomal storage disease hyperuricemia thyroid gland disease hypobetalipoproteinemia amyloidosis hematologic cancer Chediak-Higashi syndrome Sandhoff disease Tay-Sachs disease GM1 gangliosidosis adrenoleukodystrophy lipomatosis metachromatic leukodystrophy Wolman disease gangliosidosis Krabbe disease bilirubin metabolic disorder mucopolysaccharidosis III peroxisomal disease disease of metabolism lipid metabolism disorder ariboflavinosis beriberi pellagra pyridoxine deficiency anemia kwashiorkor insulinoma marasmus protein-energy malnutrition argininosuccinic aciduria rickets calcinosis | GMPR NTPCR AK4 AK2 RAB35 AK6 IDNK AK7 GUF1 URGCP EFTUD2 IFI44 GNL1 ARL13B GNL3 SMG9 ARL5A GIMAP8 IRGM ARL17B | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide Ifosfamide Tetrahydrofolic acid Cabazitaxel Gonadorelin* Lactulose* Azacitidine* Idarubicin Epirubicin Cyclophosphamide* Vincristine Prednisolone*$ Valaciclovir Everolimus* Prasterone Regorafenib* Vidarabine Fludarabine* Vinorelbine | Emtricitabine$ Lamivudine Tenofovir$ disoproxil Adefovir Dipivoxil Cidofovir Capecitabine* Decitabine$ Famciclovir Azacitidine* Sofosbuvir$ Tetrahydrofolic acid Vindesine Vidarabine Citric Acid Aciclovir Entecavir Abacavir Gemcitabine* Ticagrelor*$ Mipomersen |
| Ocular symptoms | neuroretinitis retinitis retinal artery occlusion anterior uveitis scleritis pars planitis keratitis panuveitis posterior uveitis intermediate uveitis external ear disease acute transudative otitis media chronic tubotympanic suppurative otitis media chronic atticoantral disease chronic purulent otitis media acute serous otitis media serous glue ear non-suppurative otitis media | MYH8 MYO7A MYO1H MYO5A MYO19 MYO5C MYO6 MYO5B MYO1B MYH2 MYO16 TOP2A MYO1C MYH13 MYH9 MYH15 MYH14 MYO1D NR3C2 NR4A3 | Nuclear Receptor transcription pathway | Gene expression (Transcription) Nuclear signaling by ERBB4 | Signal transduction Noncanonical activation of NOTCH3 | Signal transduction NOTCH4 Activation and Transmission of Signal to the Nucleus | Signal transduction Regulated proteolysis of p75NTR | Signal transduction Reduction of cytosolic Ca++ levels | Hemostasis Sodium/Calcium exchangers | Transport of small molecules SUMOylation of intracellular receptors | Metabolism of proteins NRIF signals cell death from the nucleus | Signal transduction Signaling by ERBB4 | Signal transduction Synthesis of very long-chain fatty acyl-CoAs | Metabolism | Prednisolone*$ Tetrahydrofolic acid Cabazitaxel Vindesine Ifosfamide* Pomalidomide Diflorasone Everolimus* Gonadorelin Idarubicin Prednisone*$ Cyclophosphamide* Paclitaxel* Lactulose Regorafenib* Vincristine* Prasterone Pravastatin* Hydrocortisone*$ Trifluridine | Diflorasone Delafloxacin Betamethasone* Besifloxacin* Gatifloxacin* Moxifloxacin*$ Perampanel Clocortolone Clobetasone Deflazacort Ulobetasol Lomefloxacin Enoxacin Fluticasone* furoate Mometasone*$ Alclometasone Triamcinolone* Desoximetasone Fluorometholone* Prednisolone*$ |
| Renal acute kidney failure injury | perineurioma Fanconi syndrome prostate disease bacterial vaginosis vasculogenic impotence oligospermia chronic kidney disease kidney cortex necrosis acute kidney tubular necrosis renal artery obstruction gliomatosis cerebri | RETSAT RDH14 RDH12 DHRS7 KCNA10 RDH13 FAM84B HRASLS5 RARRES1 RARRES3 RDH8 SLC8A3 NR4A3 ELOVL7 RDH11 ELOVL1 HRASLS2 ASMTL PLEKHG4 PLA2G16 | RAB geranylgeranylation | Metabolism of proteins | Pomalidomide* Vindesine Ifosfamide* Tetrahydrofolic acid Cabazitaxel* Everolimus* Regorafenib* Prednisolone*$ Idarubicin Cyclophosphamide* Prasterone Pravastatin* Paclitaxel* Codeine Gonadorelin Vincristine* Pyrazinamide Lactulose* Azacitidine* Valaciclovir | Citric* Acid Emtricitabine*$ Vindesine Norelgestromin Lamivudine* Calcidiol* Decitabine*$ Cidofovir* Levonorgestrel Capecitabine* Famciclovir Glimepiride* Azacitidine* Adefovir Dipivoxil Tenofovir*$ disoproxil Drostanolone Entecavir* Sofosbuvir*$ Aciclovir Vincristine* |
| Cardiovascular/arrhythmia | coronary stenosis brain infarction lymphatic system disease middle cerebral artery infarction atrioventricular block Wolff-Parkinson-White syndrome brain stem infarction coronary thrombosis intracranial arteriosclerosis pulmonary embolism and infarction intracranial thrombosis | GMPR ASMTL METTL21B TUBE1 NTPCR METTL21A AK4 AK2 TUBD1 TUT1 OAS2 RRM1 SEPT10 METTL13 RAB35 HENMT1 NDUFAF5 IDNK AK6 TFB1M | RAB geranylgeranylation | Metabolism of proteins Protein methylation | Metabolism of proteins | Pomalidomide Vindesine Ifosfamide Tetrahydrofolic acid Cabazitaxel Everolimus* Gonadorelin Azacitidine Lactulose Idarubicin Cyclophosphamide* Prednisolone*$ Epirubicin Valaciclovir Vincristine Fludarabine* Prasterone Regorafenib Vidarabine Samarium (153Sm) lexidronam | Emtricitabine*$ Lamivudine* Vindesine Decitabine$ Cidofovir Capecitabine Adefovir Dipivoxil Tenofovir$ disoproxil Famciclovir Azacitidine Abacavir* Entecavir Sofosbuvir$ Aciclovir Gemcitabine Ganciclovir Ticagrelor*$ Vidarabine Vincristine Mipomersen |
| Sepsis | hepatitis A hepatitis E hantavirus pulmonary syndrome genital herpes hepatitis D respiratory syncytial virus infectious disease X-linked hyper IgM syndrome hepatitis B | ASMTL TUBE1 TUBD1 METTL21B GMPR NTPCR RRM1 TUT1 OAS2 AK4 AK2 METTL21A POLE2 POLE4 USB1 TREX1 TOP3B CMPK1 RAB35 AK6 | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide Ifosfamide Tetrahydrofolic acid Cabazitaxel Lactulose* Gonadorelin Epirubicin Azacitidine Idarubicin Cyclophosphamide Vincristine Valaciclovir Regorafenib Vidarabine Fludarabine Prednisolone*$ Everolimus* Vinorelbine Paclitaxel | Emtricitabine*$ Lamivudine* Vindesine Cidofovir* Decitabine$ Capecitabine Adefovir Dipivoxil Tenofovir*$ disoproxil Famciclovir Azacitidine Entecavir* Sofosbuvir$ Aciclovir Vidarabine Gemcitabine Ganciclovir* Mipomersen Tenofovir$ alafenamide Penciclovir Zidovudine* |
| Hepatocellular injury/Acute hepatitis/Liver failure | biliary tract disease exocrine pancreatic insufficiency cholestasis pancreas disease gastrointestinal system disease liver cirrhosis intrahepatic cholestasis | ASMTL DGUOK TUBE1 NDUFA10 TK2 TUBD1 TAF6 OAS2 TUT1 RRM1 METTL21B CMPK1 METTL21A TOP3B TREX1 NTPCR METTL17 USB1 AK4 AK2 | RAB geranylgeranylation | Metabolism of proteins | Cabazitaxel Lactulose Ifosfamide Vindesine Gonadorelin Paclitaxel Idarubicin Tetrahydrofolic acid Vincristine Cyclophosphamide Vinorelbine Erlotinib Pomalidomide Prasterone Triptorelin Cisplatin Tibolone Betazole Docetaxel Mitoxantrone | Emtricitabine$ Lamivudine Vindesine Cidofovir Decitabine$ Famciclovir Capecitabine Entecavir Azacitidine Tenofovir$ disoproxil Adefovir Dipivoxil Doxofylline Sofosbuvir$ Aciclovir Zidovudine Penciclovir Caffeine Tegafur Gemcitabine Tenofovir$ alafenamide |
| Cerebral ischemia/infarction | brain infarction lymphatic system disease middle cerebral artery infarction brain stem infarction intracranial arteriosclerosis intracranial thrombosis | RPS19 POLR3F TCOF1 PCSK5 CUTA PXDNL SQLE | Activation of gene expression by SREBF (SREBP) | Metabolism Expression and Processing of Neurotrophins | Signal transduction NGF processing | Signal transduction Regulation of cholesterol biosynthesis by SREBP (SREBF) | Metabolism RNA Polymerase III Chain Elongation | Gene expression (Transcription) RNA Polymerase III Transcription Termination | Gene expression (Transcription) | Pomalidomide Ifosfamide Everolimus Cabazitaxel Vindesine Prednisolone$ Tetrahydrofolic acid Pravastatin Prasterone Cyclophosphamide Regorafenib Estriol Methylscopolamine bromide Medrogestone Oxytetracycline Gonadorelin Paclitaxel Trandolapril Idarubicin Gallium citrate Ga 67 | Phenyl salicylate Emtricitabine$ Selexipag Lamivudine Decitabine$ Cidofovir Famciclovir Vindesine Capecitabine Tenofovir$ disoproxil Azacitidine Adefovir Dipivoxil Entecavir Sofosbuvir$ Tenofovir$ alafenamide Doxofylline Zidovudine Aciclovir Amphetamine Penciclovir |
| Gastrointestinal symptoms | exanthem hemoglobinuria chronic fatigue syndrome papilloma pulmonary coin lesion | ASMTL TUBE1 DGUOK METTL21B TUBD1 NTPCR RRM1 TUT1 OAS2 CMPK1 TK2 NDUFA10 AK4 AK2 METTL21A TOP3B TREX1 GMPR RAB35 NDUFAF5 | RAB geranylgeranylation | Metabolism of proteins Kinesins | Hemostasis | Tetrahydrofolic acid Cabazitaxel Vindesine Pomalidomide Ifosfamide Regorafenib* Idarubicin Everolimus* Gonadorelin Lactulose* Paclitaxel* Cyclophosphamide* Vincristine Epirubicin* Prednisolone*$ Prasterone Erlotinib* Pyrazinamide Valaciclovir Azacitidine | Emtricitabine$ Vindesine Lamivudine* Cidofovir Decitabine*$ Famciclovir Entecavir* Capecitabine* Azacitidine Tenofovir*$ disoproxil Adefovir Dipivoxil Sofosbuvir*$ Aciclovir Penciclovir Doxofylline Tenofovir$ alafenamide Vincristine Ganciclovir* Zidovudine* Vidarabine |
| Bacteremia | exanthem hemoglobinuria chronic fatigue syndrome papilloma pulmonary coin lesion | ASMTL TUBE1 DGUOK METTL21B TUBD1 NTPCR RRM1 TUT1 OAS2 CMPK1 TK2 NDUFA10 AK4 AK2 METTL21A TOP3B TREX1 GMPR RAB35 NDUFAF5 | RAB geranylgeranylation | Metabolism of proteins Kinesins | Hemostasis | Tetrahydrofolic acid Cabazitaxel Vindesine Pomalidomide Ifosfamide Regorafenib Idarubicin Everolimus Gonadorelin Lactulose Paclitaxel Cyclophosphamide Vincristine Epirubicin Prednisolone$ Prasterone Erlotinib Pyrazinamide Valaciclovir Azacitidine | Emtricitabine$ Vindesine Lamivudine Cidofovir Decitabine$ Famciclovir Entecavir Capecitabine Azacitidine Tenofovir$ disoproxil Adefovir Dipivoxil Sofosbuvir$ Aciclovir Penciclovir Doxofylline Tenofovir$ alafenamide Vincristine Ganciclovir Zidovudine Vidarabine |
| Dermatologic complications/pressure ulcer | diffuse scleroderma phototoxic dermatitis rosacea | COX7A2L COX7A1 COX7A2 CELA2B ELOVL7 ELOVL1 CDC45 SLC8A3 ELOVL4 OSBPL8 KCNA10 OSBPL5 NR4A3 APH1B SLC8A1 RBP7 RBP5 GRP PMP2 SQRDL | Folding of actin by CCT/TriC | Metabolism of proteins Kinesins | Hemostasis | Pomalidomide Vindesine Ifosfamide Prasterone Tetrahydrofolic acid Cabazitaxel Azacitidine Vitamin A Prednisolone$ Lactulose Gonadorelin Epirubicin Idarubicin Cyclophosphamide Everolimus Valaciclovir Fludarabine Vidarabine Ursodeoxycholic acid Vincristine | Diflorasone Betamethasone Clobetasone Clocortolone Drostanolone Ulobetasol Mometasone*$ Levonorgestrel Deflazacort Alclometasone Carboplatin Prednisolone$ Alitretinoin Triamcinolone Fluorometholone Desoximetasone Fluticasone furoate Glycine$ Exemestane Norelgestromin |
| Respiratory failure | respiratory system disease | MYH8 MYH2 MYO19 MYO6 MYO7A MYO5B MYO1H MYO5A MYO5C MYO1B MYO16 TOP2A MYH15 MYH13 MYH9 MYO1C MYH14 MYO1D ELMO1 C9orf117 | Leishmania phagocytosis | Disease Parasite infection | Disease FCGR3A-mediated phagocytosis | Disease Regulation of actin dynamics for phagocytic cup formation | Immune system RHO GTPases activate CIT | Signal transduction RHO GTPases Activate ROCKs | Signal transduction Sema4D induced cell migration and growth-cone collapse | Developmental biology Sensory processing of sound by outer hair cells of the cochlea | Sensory perception Transcription of E2F targets under negative control by DREAM complex | Cell cycle RHO GTPases activate PAKs | Signal transduction Sema4D in semaphorin signaling | Developmental biology Fcgamma receptor (FCGR) dependent phagocytosis | Immune system Sensory processing of sound by inner hair cells of the cochlea | Sensory perception Translocation of SLC2A4 (GLUT4) to the plasma membrane | Vesicle-mediated transport EPHA-mediated growth cone collapse | Developmental biology Sensory processing of sound | Sensory perception G0 and Early G1 | Cell cycle | Acarbose Amoxicillin$ Prednisolone*$ Pefloxacin Prednisone*$ Hydrocortisone$ Tetrahydrofolic acid Cabazitaxel Cefradine Enoxacin Ceftizoxime Cefpodoxime Lomefloxacin Estriol Oritavancin Cefmenoxime Cloxacillin Isoflurane*$ Magnesium carbonate Lincomycin | Delafloxacin Gatifloxacin Moxifloxacin$ Perampanel Lomefloxacin Enoxacin Abemaciclib Pefloxacin Technetium Tc-99m pyrophosphate Sparfloxacin Liothyronine Propylthiouracil Flibanserin Diatrizoate Levofloxacin$ Rucaparib Ciprofloxacin Gemifloxacin Amrubicin Calcium Phosphate |
| Pulmonary embolism | pulmonary embolism and infarction | C5orf52 L3HYPDH DNPEP ACYP1 FBXO31 ACYP2 PARS2 LANCL3 TXNDC12 CCL8 ATXN3 GSTT2 GGT6 GSTT1 MBLAC1 PLGLB2 GLRX2 DCAF6 C5orf63 WDR47 | Glutathione conjugation | Metabolism G beta:gamma signalling through BTK | Signal transduction G beta:gamma signalling through CDC42 | Signal transduction G beta:gamma signalling through PLC beta | Signal transduction Prostacyclin signalling through prostacyclin receptor | Hemostasis Presynaptic function of Kainate receptors | Neuronal system ADP signalling through P2Y purinoceptor 12 | Hemostasis Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | Disease G-protein activation | Signal transduction Transport of the SLBP independent Mature mRNA | Metabolism of RNA SUMOylation of SUMOylation proteins | Metabolism of proteins Thromboxane signalling through TP receptor | Hemostasis G beta:gamma signalling through PI3Kgamma | Signal transduction ADP signalling through P2Y purinoceptor 1 | Hemostasis Transport of the SLBP Dependant Mature mRNA | Metabolism of RNA Regulation of Glucokinase by Glucokinase Regulatory Protein | Metabolism Nuclear import of Rev protein | Disease Nuclear Pore Complex (NPC) Disassembly | Cell cycle Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | Neuronal system Activation of G protein gated Potassium channels | Neuronal system G protein gated Potassium channels | Neuronal system SUMOylation of ubiquitinylation proteins | Metabolism of proteins Transport of Mature mRNA derived from an Intron-Containing Transcript | Metabolism of RNA Adrenaline,noradrenaline inhibits insulin secretion | Metabolism Vpr-mediated nuclear import of PICs | Disease Rev-mediated nuclear export of HIV RNA | Disease Activation of kainate receptors upon glutamate binding | Neuronal system Transport of Mature mRNA Derived from an Intronless Transcript | Metabolism of RNA Interactions of Rev with host cellular proteins | Disease NS1 Mediated Effects on Host Pathways | Disease Thrombin signalling through proteinase activated receptors (PARs) | Hemostasis Glucagon-type ligand receptors | Signal transduction Transport of Mature mRNAs Derived from Intronless Transcripts | Metabolism of RNA Interactions of Vpr with host cellular proteins | Disease GRB7 events in ERBB2 signaling | Signal transduction Transport of Ribonucleoproteins into the Host Nucleus | Disease Aflatoxin activation and detoxification | Metabolism Transport of Mature Transcript to Cytoplasm | Metabolism of RNA SUMOylation of DNA replication proteins | Metabolism of proteins Inwardly rectifying K+ channels | Neuronal system SUMOylation of RNA binding proteins | Metabolism of proteins | Gadobutrol Amphetamine Nateglinide Felbamate Ipratropium bromide Phenindione Hexylresorcinol Seratrodast Mephentermine Gadoteridol Fluvoxamine$ Pantethine Piracetam Levomethadyl Acetate Digoxin Trihexyphenidyl Cilastatin Nabilone Peramivir Ethinyl* Estradiol |
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| Pneumothorax | spontaneous tension pneumothorax | MYH8 MYH2 MYO19 MYO6 MYO7A MYO5B MYO1H MYO5A MYO5C MYO1B MYO16 TOP2A MYH15 MYH13 MYH9 MYO1C MYH14 MYO1D ELMO1 C9orf117 | Leishmania phagocytosis | Disease Parasite infection | Disease FCGR3A-mediated phagocytosis | Disease Regulation of actin dynamics for phagocytic cup formation | Immune system RHO GTPases activate CIT | Signal transduction RHO GTPases Activate ROCKs | Signal transduction Sema4D induced cell migration and growth-cone collapse | Developmental biology Sensory processing of sound by outer hair cells of the cochlea | Sensory perception Transcription of E2F targets under negative control by DREAM complex | Cell cycle RHO GTPases activate PAKs | Signal transduction Sema4D in semaphorin signaling | Developmental biology Fcgamma receptor (FCGR) dependent phagocytosis | Immune system Sensory processing of sound by inner hair cells of the cochlea | Sensory perception Translocation of SLC2A4 (GLUT4) to the plasma membrane | Vesicle-mediated transport EPHA-mediated growth cone collapse | Developmental biology Sensory processing of sound | Sensory perception G0 and Early G1 | Cell cycle | Acarbose Amoxicillin$ Prednisolone$ Pefloxacin Prednisone$ Hydrocortisone$ Tetrahydrofolic acid Cabazitaxel Cefradine Enoxacin Ceftizoxime Cefpodoxime Lomefloxacin Estriol Oritavancin Cefmenoxime Cloxacillin Isoflurane$ Magnesium carbonate Lincomycin | Delafloxacin Gatifloxacin Moxifloxacin$ Perampanel Lomefloxacin Enoxacin Abemaciclib Pefloxacin Technetium Tc-99m pyrophosphate Sparfloxacin Liothyronine Propylthiouracil Flibanserin Diatrizoate Levofloxacin$ Rucaparib Ciprofloxacin Gemifloxacin Amrubicin Calcium Phosphate |
| Pneuomonia | pleuropneumonia | SLC8A3 KCNA10 NR4A3 ELOVL7 ELOVL1 NR3C2 ELOVL4 APH1A COX7A1 COX7A2 COX7A2L TSPAN13 NUP107 GRP ITGB7 ITGB5 OSBPL8 OSBPL5 LXN RARRES1 | Nuclear Receptor transcription pathway | Gene expression (Transcription) Signaling by Retinoic Acid | Signal transduction RUNX1 regulates expression of components of tight junctions | Gene expression (Transcription) PP2A-mediated dephosphorylation of key metabolic factors | Metabolism Acyl chain remodelling of PE | Metabolism E2F mediated regulation of DNA replication | Cell cycle RUNX3 Regulates Immune Response and Cell Migration | Gene expression (Transcription) MASTL Facilitates Mitotic Progression | Cell cycle Synthesis of very long-chain fatty acyl-CoAs | Metabolism | Prednisolone*$ Prednisone*$ Fludrocortisone* Hydrocortisone*$ Ifosfamide Oxytetracycline Prasterone Pravastatin* Flunisolide* Everolimus* Aminosalicylic Acid Pamidronate Mepivacaine Amoxicillin*$ Tolfenamic Acid Isoflurane$ Propofol*$ Pomalidomide* Alendronic acid Hydroxocobalamin | Betamethasone* Norelgestromin Mometasone$ Triamcinolone Gestrinone Exemestane Fluorometholone Gestodene Prednisolone*$ Medrogestone Carboplatin* Levonorgestrel Dienogest Fludrocortisone* Norgestimate Fluoxymesterone Calcidiol Spironolactone$ Tixocortol Fluticasone furoate |
| DIC | purpura fulminans | RPS19 TCOF1 POLR3F DDRGK1 YARS2 PXDNL PTH2 TMEM64 FARS2 PCSK5 ABHD1 PTGS1 BCL2L1 KCNK3 KCNK9 LRRC47 | TWIK-releated acid-sensitive K+ channel (TASK) | Neuronal system BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | Programmed cell death Tandem pore domain potassium channels | Neuronal system Phase 4 - resting membrane potential | Muscle contraction STAT5 activation downstream of FLT3 ITD mutants | Disease Signaling by FLT3 ITD and TKD mutants | Disease FLT3 signaling in disease | Disease Mitochondrial tRNA aminoacylation | Metabolism of proteins The NLRP1 inflammasome | Immune system Expression and Processing of Neurotrophins | Signal transduction NGF processing | Signal transduction Intrinsic Pathway for Apoptosis | Programmed cell death COX reactions | Metabolism tRNA Aminoacylation | Metabolism of proteins | Prednisolone$ Estriol Mepivacaine Flunisolide Barium sulfate Isoflurane$ Codeine Fluocinonide Orphenadrine Medrogestone Sevoflurane$ Lurasidone Fluorometholone Enflurane Alimemazine Triflupromazine Promazine$ Meticillin Acarbose Paliperidone | Isocarboxazid Triflusal Calcium Phosphate Sodium phosphate Phenyl salicylate Diflunisal Tiaprofenic acid Salsalate Stanozolol Phenelzine Olsalazine Pargyline Acenocoumarol Liothyronine Salicylamide Aminosalicylic Acid Acetylsalicylic$ acid Lumiracoxib Rasagiline Amphetamine |
| Asthma exacerbation | cough variant asthma | MYH8 MYH2 MYO19 MYO6 MYO7A MYO5B MYO1H MYO5A MYO5C MYO1B MYO16 TOP2A MYH15 MYH13 MYH9 MYO1C MYH14 MYO1D ELMO1 C9orf117 | Leishmania phagocytosis | Disease Parasite infection | Disease FCGR3A-mediated phagocytosis | Disease Regulation of actin dynamics for phagocytic cup formation | Immune system RHO GTPases activate CIT | Signal transduction RHO GTPases Activate ROCKs | Signal transduction Sema4D induced cell migration and growth-cone collapse | Developmental biology Sensory processing of sound by outer hair cells of the cochlea | Sensory perception Transcription of E2F targets under negative control by DREAM complex | Cell cycle RHO GTPases activate PAKs | Signal transduction Sema4D in semaphorin signaling | Developmental biology Fcgamma receptor (FCGR) dependent phagocytosis | Immune system Sensory processing of sound by inner hair cells of the cochlea | Sensory perception Translocation of SLC2A4 (GLUT4) to the plasma membrane | Vesicle-mediated transport EPHA-mediated growth cone collapse | Developmental biology Sensory processing of sound | Sensory perception G0 and Early G1 | Cell cycle | Acarbose Amoxicillin$ Prednisolone*$ Pefloxacin Prednisone*$ Hydrocortisone*$ Tetrahydrofolic acid Cabazitaxel Cefradine Enoxacin Ceftizoxime Cefpodoxime Lomefloxacin Estriol Oritavancin Cefmenoxime Cloxacillin Isoflurane$ Magnesium carbonate Lincomycin | Delafloxacin Gatifloxacin Moxifloxacin*$ Perampanel Lomefloxacin Enoxacin Abemaciclib Pefloxacin Technetium Tc-99m pyrophosphate Sparfloxacin Liothyronine Propylthiouracil Flibanserin Diatrizoate Levofloxacin$ Rucaparib Ciprofloxacin Gemifloxacin Amrubicin Calcium Phosphate |
| Acute myocardial infarction | coronary thrombosis | ATP5D GLRA1 GRIA4 TLE1 RPS19 PACRGL GRID1 MKL1 CLSTN3 PHTF2 PPP3R2 FKBP5 DCAF4L2 FAM8A1 | MECP2 regulates neuronal receptors and channels | Gene expression (Transcription) Activation of AMPA receptors | Neuronal system Transcriptional Regulation by MECP2 | Gene expression (Transcription) Repression of WNT target genes | Signal transduction | Acarbose Clarithromycin$ Everolimus* Codeine Methylscopolamine bromide Ifosfamide Flunisolide Lenalidomide$ Cefprozil Ampicillin Lomefloxacin Mepivacaine Lansoprazole Amoxicillin$ Cefradine Caffeine* Kanamycin Cefotiam Troleandomycin Pefloxacin | Halothane Methoxyflurane* Digoxin Sevoflurane*$ Desflurane Temsirolimus Sirolimus*$ Enflurane Everolimus* Isoflurane$ Spiramycin Josamycin Methylscopolamine bromide Carbachol Telithromycin Triflusal Netilmicin Bethanechol Fluocinonide Acarbose |
| ARDS | adult respiratory distress syndrome | RETSAT KCNA10 SLC8A3 RDH14 RDH12 RARRES1 OSBPL8 NR4A3 DHRS7 OSBPL5 HRASLS5 ELOVL7 LXN ELOVL1 COX7A2L COX7A1 COX7A2 RDH8 ASMTL ELOVL4 | RAB geranylgeranylation | Metabolism of proteins Nuclear Receptor transcription pathway | Gene expression (Transcription) | Tetrahydrofolic acid Vindesine Ifosfamide Cabazitaxel Pomalidomide Prednisolone*$ Regorafenib Idarubicin Codeine Cyclophosphamide Paclitaxel Everolimus Gonadorelin Lactulose Prasterone Epirubicin Vincristine Pravastatin Pyrazinamide Prednisone$ | Betamethasone* Levonorgestrel Prednisolone*$ Norelgestromin Mometasone$ Deflazacort Exemestane Triamcinolone Calcidiol Gestodene Fluorometholone Gestrinone Carboplatin Fluticasone furoate Emtricitabine$ Dienogest Tixocortol Ergocalciferol Medrogestone Fluoxymesterone |