Hierarchically ranked comorbidities, comorbidity enriched MOA proteins, pathways and the top 20 drugs for each COVID-19 clinical manifestation from the GWAS risk genes2 as input results.
| Clinical manifestation | Comorbidities | Comorbidity enriched MOA proteins | Pathways | Top pathways | CoMOAdrug drugs | CoVLS drugs |
|---|---|---|---|---|---|
| Neurologic | congenital myasthenic syndrome myotonia congenita facial neuralgia Charcot-Marie-Tooth disease type 2 idiopathic peripheral autonomic neuropathy multiple system atrophy autonomic nervous system disease Lambert-Eaton myasthenic syndrome peripheral nervous system disease movement disease focal hand dystonia complex regional pain syndrome femoral neuropathy lingual-facial-buccal dyskinesia Riley-Day syndrome Parkinson's disease reflex sympathetic dystrophy Huntington's disease spastic quadriplegia spastic monoplegia Parkinson's disease 23 Parkinson's disease 4 Parkinson's disease 19A sleep disorder anterior horn cell disease critical illness polyneuropathy generalized dystonia dystonia nervous system disease Alzheimer's disease encephalomalacia migraine with aura early myoclonic encephalopathy Lewy body dementia motor neuron disease restless legs syndrome lateral sclerosis muscular atrophy carpal tunnel syndrome neurodegenerative disease chronic fatigue syndrome facioscapulohumeral muscular dystrophy pantothenate kinase-associated neurodegeneration dentatorubral-pallidoluysian atrophy progressive myoclonus epilepsy Unverricht-Lundborg syndrome epilepsy narcolepsy neuroleptic malignant syndrome multiple sclerosis neurodegeneration with brain iron accumulation 6 neurodegeneration with brain iron accumulation 5 neurodegeneration with brain iron accumulation 4 neurodegeneration with brain iron accumulation 2b neurodegeneration with brain iron accumulation 2a Huntington's disease-like 2 Huntington's disease-like 1 torsion dystonia with onset in infancy X-linked dystonia-parkinsonism dystonia 12 dystonia 25 episodic kinesigenic dyskinesia 2 episodic kinesigenic dyskinesia 1 dystonia 24 dystonia 23 dystonia 27 striatonigral degeneration paroxysmal nonkinesigenic dyskinesia 1 dystonia 16 paroxysmal nonkinesigenic dyskinesia 2 dystonia 21 childhood onset GLUT1 deficiency syndrome 2 dystonia 9 dystonia 5 torsion dystonia 17 torsion dystonia 4 torsion dystonia 6 torsion dystonia 2 torsion dystonia 13 myoclonic dystonia 11 syndromic X-linked intellectual disability type 10 benign shuddering attacks postencephalitic Parkinson disease torsion dystonia 1 hyperekplexia 3 hyperekplexia 2 hyperekplexia 1 hyperekplexia extrapyramidal and movement disease secondary Parkinson disease choreatic disease sleep apnea blepharospasm obstructive sleep apnea epilepsy with generalized tonic-clonic seizures reflex epilepsy juvenile spinal muscular atrophy migraine focal epilepsy childhood absence epilepsy essential tremor | C5orf52 L3HYPDH SV2A DNPEP RNPEP SV2B GATM ACYP1 FBXO31 ACYP2 LANCL3 CCL8 TXNDC12 SV2C PARS2 ATXN3 OR2A1 SEC31A GSTT2 GGT6 | Glutathione conjugation | Metabolism Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules G-protein activation | Signal transduction G beta:gamma signalling through BTK | Signal transduction G beta:gamma signalling through CDC42 | Signal transduction G beta:gamma signalling through PLC beta | Signal transduction Prostacyclin signalling through prostacyclin receptor | Hemostasis Presynaptic function of Kainate receptors | Neuronal system ADP signalling through P2Y purinoceptor 12 | Hemostasis Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | Disease Toxicity of botulinum toxin type D (botD) | Disease Toxicity of botulinum toxin type F (botF) | Disease Transport of the SLBP independent Mature mRNA | Metabolism of RNA SUMOylation of SUMOylation proteins | Metabolism of proteins Thromboxane signalling through TP receptor | Hemostasis G beta:gamma signalling through PI3Kgamma | Signal transduction ADP signalling through P2Y purinoceptor 1 | Hemostasis Transport of the SLBP Dependant Mature mRNA | Metabolism of RNA Regulation of Glucokinase by Glucokinase Regulatory Protein | Metabolism Nuclear import of Rev protein | Disease Nuclear Pore Complex (NPC) Disassembly | Cell cycle G protein gated Potassium channels | Neuronal system Activation of G protein gated Potassium channels | Neuronal system Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | Neuronal system Toxicity of botulinum toxin type A (botA) | Disease SUMOylation of ubiquitinylation proteins | Metabolism of proteins Adrenaline,noradrenaline inhibits insulin secretion | Metabolism Transport of Mature mRNA derived from an Intron-Containing Transcript | Metabolism of RNA Vpr-mediated nuclear import of PICs | Disease Rev-mediated nuclear export of HIV RNA | Disease Activation of kainate receptors upon glutamate binding | Neuronal system Transport of Mature mRNA Derived from an Intronless Transcript | Metabolism of RNA Interactions of Rev with host cellular proteins | Disease NS1 Mediated Effects on Host Pathways | Disease Thrombin signalling through proteinase activated receptors (PARs) | Hemostasis Glucagon-type ligand receptors | Signal transduction Transport of Mature mRNAs Derived from Intronless Transcripts | Metabolism of RNA Interactions of Vpr with host cellular proteins | Disease Transport of Ribonucleoproteins into the Host Nucleus | Disease Transport of Mature Transcript to Cytoplasm | Metabolism of RNA SUMOylation of DNA replication proteins | Metabolism of proteins Inwardly rectifying K+ channels | Neuronal system SUMOylation of RNA binding proteins | Metabolism of proteins | Codeine* Paliperidone* Prasterone* Trihexyphenidyl* Prednisolone*$ Naltrexone*$ Temazepam* Methylscopolamine bromide Orphenadrine* Pravastatin Medrogestone Drostanolone Estriol Mepivacaine* Alprazolam* Tetrahydrofolic acid Imipramine* Pomalidomide Flurazepam* Triazolam* | Amphetamine* Mephentermine Modafinil* Ipratropium bromide Trihexyphenidyl* Levomethadyl Acetate Imipramine* Methadone* Drostanolone Gadobutrol Naltrexone*$ Tiagabine Pseudoephedrine* Pipobroman Fluvoxamine*$ Felbamate Levonorgestrel* Nateglinide Methyldopa* Butabarbital |
| Cardiovascular/Arrhythmia | carotid stenosis brain ischemia renal artery disease acute anterolateral myocardial infarction acute inferolateral myocardial infarction acute inferoposterior infarction subendocardial infarction acute myocardial infarction strictly posterior acute myocardial infarction arrhythmogenic right ventricular cardiomyopathy myocardial stunning arteriosclerosis obliterans left bundle branch hemiblock mitral valve stenosis Dressler's syndrome aortic aneurysm abdominal aortic aneurysm intracranial embolism aortic valve insufficiency long QT syndrome peripheral vascular disease lymphedema thromboangiitis obliterans cardiac arrest thoracic aortic aneurysm intermediate coronary syndrome cardiovascular system disease acute myocardial infarction congestive heart failure myocardial infarction heart disease hypertensive heart disease secondary hypertension cerebral arterial disease essential hypertension coronary artery disease cerebrovascular disease pulmonary embolism and infarction aortic disease atrial fibrillation renovascular hypertension nephrosclerosis dilated cardiomyopathy coronary artery vasospasm ischemia hypertension systolic heart failure heart valve disease cardiomyopathy atrioventricular block varicose veins hypertrophic cardiomyopathy | APLNR ADRB3 PTGDR2 OR52B4 F2RL2 GPR25 ADRB2 TACR2 OR5M1 GALR1 CXCR6 XCR1 SUCNR1 OR13A1 TAAR6 OR5M10 OR52N2 BRS3 GPR149 KISS1R | Class A/1 (Rhodopsin-like receptors) | Signal transduction GPCR ligand binding | Signal transduction Peptide ligand-binding receptors | Signal transduction GPCR downstream signalling | Signal transduction Signaling by GPCR | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease Amine ligand-binding receptors | Signal transduction G alpha (s) signalling events | Signal transduction Anti-inflammatory response favouring Leishmania parasite infection | Disease Leishmania parasite growth and survival | Disease Adrenoceptors | Signal transduction G alpha (i) signalling events | Signal transduction Olfactory Signaling Pathway | Signal transduction Tachykinin receptors bind tachykinins | Signal transduction Leishmania infection | Disease Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) | Disease G alpha (q) signalling events | Signal transduction | Codeine* Trandolapril* Acarbose* Prasterone Ramipril*$ Prednisolone*$ Enalapril* Pravastatin* Betaxolol Paliperidone Reserpine* Caffeine* Nimodipine Pindolol Estriol Olmesartan* Medrogestone Temazepam Trihexyphenidyl Orphenadrine | Modafinil Mephentermine Salbutamol* Imipramine* Amphetamine* Orciprenaline Tolazoline Pinaverium Betaxolol Epirubicin Naltrexone*$ Timolol Trihexyphenidyl Drostanolone Pseudoephedrine Levonorgestrel Oxprenolol Nimodipine Citalopram* Tiagabine |
| Endocrine | obsolete Cushing's syndrome nodular goiter hyperinsulinemic hypoglycemia alpha 1-antitrypsin deficiency hyperthyroidism adrenal gland hyperfunction Addison's disease premature menopause premature ovarian failure phenylketonuria empty sella syndrome diabetic polyneuropathy familial hyperlipidemia diabetes mellitus non-renal secondary hyperparathyroidism diabetic neuropathy morbid obesity primary hyperaldosteronism Conn's syndrome adrenal cortical hypofunction type 2 diabetes mellitus diabetic retinopathy hyperlipoproteinemia type IV hypoglycemia familial partial lipodystrophy cerebrotendinous xanthomatosis xanthomatosis glycine encephalopathy hypothyroidism amino acid metabolic disorder hypogonadism hyperinsulinism abdominal obesity-metabolic syndrome 1 obesity pellagra ariboflavinosis beriberi | COX7A1 COX7A2L COX7A2 ELOVL7 ELOVL1 SLC8A3 NR4A3 ELOVL4 CELA2B SLC8A1 APH1B KALRN OSBPL5 OSBPL8 LXN GRP RARRES1 KCNA10 TSPAN13 PLEKHG4 | Olfactory Signaling Pathway | Signal transduction Nuclear Receptor transcription pathway | Gene expression (Transcription) Sensory Perception | Sensory perception SUMOylation of intracellular receptors | Metabolism of proteins | Prasterone Prednisolone*$ Codeine Gallium citrate Ga 67 Drostanolone Pravastatin* Gonadorelin* Prednisone*$ Ifosfamide Estriol Tetrahydrofolic acid Pomalidomide Vindesine Medrogestone Magnesium carbonate Hydrocortisone*$ Tibolone Cabazitaxel Lactulose* Fludrocortisone* | Betamethasone* Levonorgestrel* Drostanolone Prednisolone*$ Citric Acid Mometasone$ Norelgestromin Carboplatin* Deflazacort Gestodene Calcidiol Triamcinolone* Exemestane Fluorometholone Carboprost Tromethamine Gestrinone Alprostadil Fluticasone furoate Ergocalciferol* Tixocortol |
| Ocular symptoms | auditory system disease ocular hyperemia amblyopia suppression amblyopia Brown's tendon sheath syndrome internuclear ophthalmoplegia ocular motility disease low tension glaucoma primary open angle glaucoma residual stage of open angle glaucoma borderline glaucoma chronic closed-angle glaucoma primary angle-closure glaucoma residual stage angle-closure glaucoma acute closed-angle glaucoma interval angle-closure glaucoma aqueous misdirection hypersecretion glaucoma optic nerve disease central sleep apnea eye accommodation disease eye disease glaucoma open-angle glaucoma Foster-Kennedy syndrome retinal disease central nervous system origin vertigo cycloplegia retinitis pigmentosa retinal degeneration ocular hypertension | NR4A3 NR3C2 KCNA10 NR3C1 OSBPL5 OSBPL8 PGR SLC8A3 TSPAN13 ANXA1 NUP107 ARFGEF2 GRP ELOVL7 SLC8A1 TMEM86B ELOVL1 ARFGEF1 COX7A2L COX7A1 | Nuclear Receptor transcription pathway | Gene expression (Transcription) SUMOylation of intracellular receptors | Metabolism of proteins Reduction of cytosolic Ca++ levels | Hemostasis Sodium/Calcium exchangers | Transport of small molecules Noncanonical activation of NOTCH3 | Signal transduction PP2A-mediated dephosphorylation of key metabolic factors | Metabolism Molecules associated with elastic fibres | Extracellular matrix organization E2F mediated regulation of DNA replication | Cell cycle | Prednisolone*$ Framycetin Dicloxacillin Piperacillin$ Prednisone*$ Prasterone Amikacin Hydrocortisone*$ Fludrocortisone Tafluprost* Gentamicin* Pefloxacin Lomefloxacin Codeine Demecarium Kanamycin Travoprost* Amoxicillin*$ Carbachol Viomycin | Diflorasone Betamethasone* Clocortolone Clobetasone Levonorgestrel* Deflazacort Prednisolone*$ Alitretinoin Ulobetasol Mometasone*$ Alclometasone Fluticasone* furoate Triamcinolone* Desoximetasone Fluorometholone* Loteprednol* Carboplatin* Gestodene Norelgestromin Exemestane |
| Respiratory | upper respiratory tract disease lower respiratory tract disease vasomotor rhinitis allergic asthma intrinsic asthma croup asthma chronic rhinitis status asthmaticus pulmonary emphysema obstructive lung disease rhinitis pulmonary fibrosis adult respiratory distress syndrome nasopharyngitis maple bark strippers' lung cork-handlers' disease mushroom workers' lung malt worker's lung farmer's lung bird fancier's lung bagassosis ventilation pneumonitis chronic obstructive pulmonary disease lymphangioleiomyomatosis bronchiolitis tonsillitis pulmonary edema respiratory failure lung disease | COX7A1 COX7A2L COX7A2 NR4A3 ELOVL7 ELOVL1 ANXA1 NR3C2 NR3C1 OSBPL8 TSPAN13 OSBPL5 PRLR ITGB6 APH1B ITGB7 ITGB5 OR5AK2 LXN IL22RA2 | Nuclear Receptor transcription pathway | Gene expression (Transcription) Olfactory Signaling Pathway | Signal transduction Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Class A/1 (Rhodopsin-like receptors) | Signal transduction Amine ligand-binding receptors | Signal transduction Peptide ligand-binding receptors | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease G alpha (s) signalling events | Signal transduction Relaxin receptors | Signal transduction Noncanonical activation of NOTCH3 | Signal transduction PP2A-mediated dephosphorylation of key metabolic factors | Metabolism | Prednisolone*$ Codeine* Dicloxacillin Piperacillin*$ Caffeine* Pefloxacin Ipratropium* bromide Prasterone Kanamycin Lomefloxacin Amoxicillin*$ Pravastatin Viomycin Ampicillin* Ceftizoxime Temazepam* Cefradine Cefpodoxime Cefmenoxime Fludrocortisone | Betamethasone* Deflazacort Levonorgestrel Citric* Acid Prednisolone*$ Modafinil* Mometasone*$ Fluticasone* furoate Drostanolone Mephentermine Digoxin* Triamcinolone* Fluorometholone Amphetamine Exemestane Salbutamol* Imipramine Calcidiol Norelgestromin Gestodene |
| Hepatocellular injury/Acute hepatitis/liver failure | biliary dyskinesia acalculous cholecystitis cholecystitis choledocholithiasis acute pancreatitis hepatorenal syndrome postgastrectomy syndrome alcoholic liver cirrhosis liver disease pancreatic steatorrhea strawberry gallbladder postcholecystectomy syndrome hydrops of gallbladder occlusion of gallbladder ascending cholangitis suppurative cholangitis perforation of bile duct coronary artery disease cholelithiasis cholecystolithiasis blind loop syndrome dumping syndrome gallbladder disease primary biliary cirrhosis drug-induced hepatitis intrahepatic cholestasis short bowel syndrome liver cirrhosis pancreatitis | CX3CR1 OR51V1 CMKLR1 CCR5 CCR2 CHRM3 GPR132 GPR32 OR4K5 OR10G7 CHRM5 CCRL2 CHRM1 CCR1 OR51E2 OR2J2 OR10H5 OR4N2 OR10S1 OR5C1 | Olfactory Signaling Pathway | Signal transduction APC truncation mutants have impaired AXIN binding | Disease AXIN missense mutants destabilize the destruction complex | Disease Truncations of AMER1 destabilize the destruction complex | Disease Signaling by APC mutants | Disease Signaling by GSK3beta mutants | Disease Signaling by AMER1 mutants | Disease Signaling by AXIN mutants | Disease Signaling by CTNNB1 phospho-site mutants | Disease T41 mutants of beta-catenin aren't phosphorylated | Disease S33 mutants of beta-catenin aren't phosphorylated | Disease S45 mutants of beta-catenin aren't phosphorylated | Disease S37 mutants of beta-catenin aren't phosphorylated | Disease Chemokine receptors bind chemokines | Signal transduction Beta-catenin phosphorylation cascade | Signal transduction Platelet sensitization by LDL | Hemostasis CTLA4 inhibitory signaling | Immune system Sensory Perception | Sensory perception Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | Cell cycle Amplification of signal from the kinetochores | Cell cycle Muscarinic acetylcholine receptors | Signal transduction Disassembly of the destruction complex and recruitment of AXIN to the membrane | Signal transduction G beta:gamma signalling through BTK | Signal transduction Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 | Cell cycle TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | Gene expression (Transcription) G beta:gamma signalling through CDC42 | Signal transduction Degradation of beta-catenin by the destruction complex | Signal transduction PP2A-mediated dephosphorylation of key metabolic factors | Metabolism Mitotic Spindle Checkpoint | Cell cycle Class A/1 (Rhodopsin-like receptors) | Signal transduction G beta:gamma signalling through PLC beta | Signal transduction Prostacyclin signalling through prostacyclin receptor | Hemostasis Presynaptic function of Kainate receptors | Neuronal system Signaling by WNT in cancer | Disease Trafficking and processing of endosomal TLR | Immune system | Codeine Prasterone Drostanolone Lactulose Prednisolone$ Gonadorelin Cabazitaxel Paclitaxel Ifosfamide Pravastatin Tibolone Naltrexone$ Tetrahydrofolic acid Erlotinib Docetaxel Methylscopolamine bromide Idarubicin Mepivacaine Estriol Temazepam | Ipratropium bromide Propantheline Trihexyphenidyl Cisatracurium besylate Cevimeline Drostanolone Naltrexone$ Oxyphencyclimine Meclizine Levomethadyl Acetate Amphetamine Methadone Imipramine Metixene Mivacurium Mephentermine Solifenacin Buprenorphine Levonorgestrel Tiotropium |
| Renal/Acute kidney failure injury | gynecomastia premenstrual tension female reproductive system disease kidney hypertrophy non-congenital cyst of kidney pyeloureteritis cystica impaired renal function disease nephrosclerosis ureterolithiasis enterocele breast fibrocystic disease nephrolithiasis urethral disease endometriosis chronic interstitial cystitis interstitial cystitis | SLC8A3 ELOVL7 NR4A3 KCNA10 ELOVL1 RARRES3 LXN PLEKHG4 HRASLS5 COX7A2L COX7A2 COX7A1 ELOVL4 PLA2G16 FAM84A FAM84B NR0B1 KALRN OSBPL8 OSBPL5 | Nuclear Receptor transcription pathway | Gene expression (Transcription) The canonical retinoid cycle in rods (twilight vision) | Signal transduction Acyl chain remodelling of PS | Metabolism Small interfering RNA (siRNA) biogenesis | Gene expression (Transcription) | Dicloxacillin Piperacillin*$ Pefloxacin Lomefloxacin Viomycin Amoxicillin*$ Kanamycin Cefradine Ceftizoxime Cefmenoxime Cefprozil Ampicillin* Cephalexin* Ceftibuten* Cefoperazone Cefpiramide Cefmetazole Cefaclor Cefamandole Cefapirin | Levonorgestrel Citric* Acid Betamethasone Calcidiol* Norelgestromin Drostanolone Prednisolone*$ Ergocalciferol* Glimepiride* Exemestane* Carboplatin* Gestrinone Gestodene Mometasone$ Medrogestone Dienogest Carboprost Tromethamine Methylscopolamine bromide Triamcinolone Alprostadil* |
| Cerebral ischemia/infarction | carotid stenosis brain ischemia renal artery disease arteriosclerosis obliterans aortic aneurysm abdominal aortic aneurysm intracranial embolism peripheral vascular disease lymphedema thromboangiitis obliterans thoracic aortic aneurysm cerebral arterial disease cerebrovascular disease varicose veins | PTGDR2 APLNR F2RL2 GPR25 CXCR6 XCR1 GALR1 OR12D2 ADRB3 OR52B4 GPR55 SUCNR1 CCR9 BRS3 NPY2R TACR2 ADRB2 OR5M10 GALR3 OR5M1 | Class A/1 (Rhodopsin-like receptors) | Signal transduction GPCR ligand binding | Signal transduction Peptide ligand-binding receptors | Signal transduction GPCR downstream signalling | Signal transduction Signaling by GPCR | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease G alpha (s) signalling events | Signal transduction Amine ligand-binding receptors | Signal transduction Anti-inflammatory response favouring Leishmania parasite infection | Disease Leishmania parasite growth and survival | Disease Adrenoceptors | Signal transduction G alpha (i) signalling events | Signal transduction Tachykinin receptors bind tachykinins | Signal transduction Relaxin receptors | Signal transduction Leishmania infection | Disease Chemokine receptors bind chemokines | Signal transduction Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) | Disease G alpha (q) signalling events | Signal transduction | Codeine Acarbose Paliperidone Trandolapril Naltrexone$ Prasterone Ramipril$ Cabazitaxel Mepivacaine Reserpine Pravastatin Lactulose Caffeine Prednisolone$ Enalapril Temazepam Medrogestone Betaxolol Gonadorelin Pindolol | Naltrexone$ Salbutamol Mephentermine Modafinil Imipramine Timolol Orciprenaline Buprenorphine Epirubicin Betaxolol Morphine$ Tolazoline Codeine Amphetamine Trihexyphenidyl Oxprenolol Levallorphan Amitriptyline Bisoprolol Drostanolone |
| Acute myocardial infarction | acute anterolateral myocardial infarction acute inferolateral myocardial infarction acute inferoposterior infarction subendocardial infarction acute myocardial infarction strictly posterior acute myocardial infarction intermediate coronary syndrome acute myocardial infarction myocardial infarction coronary artery disease coronary artery vasospasm | ADRB3 SLC6A16 SLC6A5 SLC6A20 SLC6A7 SLC6A14 SLC6A9 TACR2 OR5M1 SLC6A15 APLNR OR52B4 SLC6A6 SLC6A13 ADRB2 SLC6A12 OR52N2 YARS2 TAAR9 TAAR6 | Class A/1 (Rhodopsin-like receptors) | Signal transduction Amine ligand-binding receptors | Signal transduction GPCR ligand binding | Signal transduction GPCR downstream signalling | Signal transduction Adrenoceptors | Signal transduction Signaling by GPCR | Signal transduction Olfactory Signaling Pathway | Signal transduction Peptide ligand-binding receptors | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease G alpha (s) signalling events | Signal transduction Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Dopamine receptors | Signal transduction TWIK-releated acid-sensitive K+ channel (TASK) | Neuronal system Sensory Perception | Sensory perception Opsins | Signal transduction G alpha (i) signalling events | Signal transduction Anti-inflammatory response favouring Leishmania parasite infection | Disease Leishmania parasite growth and survival | Disease G alpha (q) signalling events | Signal transduction Adrenaline signalling through Alpha-2 adrenergic receptor | Hemostasis Tachykinin receptors bind tachykinins | Signal transduction Histamine receptors | Signal transduction Serotonin receptors | Signal transduction | Trandolapril Prednisolone*$ Codeine Paliperidone Ramipril*$ Enalapril Temazepam Pravastatin* Prasterone Trihexyphenidyl Caffeine* Orphenadrine Betaxolol Medrogestone Methylscopolamine bromide Estriol Reserpine Nimodipine Epinephrine* Pindolol | Modafinil Mephentermine Pinaverium Salbutamol Tiagabine Amphetamine Tolazoline Orciprenaline Imipramine* Betaxolol Citalopram* Pseudoephedrine Epirubicin Trihexyphenidyl Timolol Oxprenolol Selegiline Mirabegron Bisoprolol* Naltrexone*$ |
| Hematologic | methemoglobinemia hemorrhagic disease lymphopenia hypersplenism myofascial pain syndrome autoimmune lymphoproliferative syndrome sickle cell anemia platelet storage pool deficiency | COX7A2L COX7A1 COX7A2 SLC8A3 ELOVL7 NR4A3 ELOVL1 ELOVL4 SLC8A1 APH1B OR2A1 GPR4 RARRES1 KALRN CELA2B PTGER1 SF3B1 APH1A SHBG MC1R | Olfactory Signaling Pathway | Signal transduction Nuclear Receptor transcription pathway | Gene expression (Transcription) Class A/1 (Rhodopsin-like receptors) | Signal transduction Sensory Perception | Sensory perception Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Eicosanoid ligand-binding receptors | Signal transduction Peptide ligand-binding receptors | Signal transduction GPCR ligand binding | Signal transduction Prostanoid ligand receptors | Signal transduction Adenosine P1 receptors | Signal transduction Histamine receptors | Signal transduction | Prasterone Prednisolone*$ Codeine* Drostanolone Pomalidomide* Vindesine Ifosfamide* Cabazitaxel* Pravastatin* Tetrahydrofolic acid Paliperidone Temazepam Gonadorelin Methylscopolamine bromide Orphenadrine Medrogestone Everolimus* Prednisone*$ Estriol* Regorafenib* | Drostanolone Levonorgestrel* Betamethasone Modafinil* Imipramine Naltrexone$ Prednisolone*$ Mephentermine Tolazoline Carboplatin* Carboprost Tromethamine Amphetamine Trihexyphenidyl Alprostadil Mometasone*$ Citalopram Calcidiol Ergocalciferol Testosterone*$ Buprenorphine* |
| Gastrointestinal symptoms | sexual dysfunction alexia disease chronic fatigue syndrome papilloma hyperglycemia | SLC6A20 SLC6A16 SLC6A7 SLC6A14 SLC6A5 SLC6A15 SLC6A9 SLC6A6 SLC6A13 SLC6A2 SLC6A3 SLC6A12 TMEM64 SLC6A4 SLC6A17 OR2A1 SLC6A1 HCAR2 GPR4 OR4A5 | Amine ligand-binding receptors | Signal transduction Class A/1 (Rhodopsin-like receptors) | Signal transduction GPCR ligand binding | Signal transduction Signaling by GPCR | Signal transduction Peptide ligand-binding receptors | Signal transduction GPCR downstream signalling | Signal transduction Adrenoceptors | Signal transduction Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Dopamine receptors | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease G alpha (s) signalling events | Signal transduction G alpha (i) signalling events | Signal transduction Reuptake of GABA | Neuronal system Adrenaline signalling through Alpha-2 adrenergic receptor | Hemostasis G alpha (q) signalling events | Signal transduction Serotonin receptors | Signal transduction Orexin and neuropeptides FF and QRFP bind to their respective receptors | Signal transduction TWIK-releated acid-sensitive K+ channel (TASK) | Neuronal system Tachykinin receptors bind tachykinins | Signal transduction Histamine receptors | Signal transduction Hormone ligand-binding receptors | Signal transduction Leishmania parasite growth and survival | Disease Anti-inflammatory response favouring Leishmania parasite infection | Disease Eicosanoid ligand-binding receptors | Signal transduction | Tetrahydrofolic acid Cabazitaxel Regorafenib* Pomalidomide Ifosfamide Vindesine Paliperidone Codeine* Everolimus* Prasterone Temazepam Naltrexone*$ Gallium citrate Ga 67 Trihexyphenidyl Idarubicin Docetaxel* Paclitaxel* Gonadorelin Pravastatin* Methylscopolamine bromide | Modafinil* Mephentermine Amphetamine Imipramine* Tiagabine Naltrexone*$ Tolazoline Salbutamol Trihexyphenidyl Orciprenaline Drostanolone Citalopram* Citric* Acid Levallorphan Pseudoephedrine Ipratropium bromide Pinaverium* Morphine*$ Buprenorphine* Codeine* |
| Bacteremia | sexual dysfunction alexia disease chronic fatigue syndrome papilloma hyperglycemia | SLC6A20 SLC6A16 SLC6A7 SLC6A14 SLC6A5 SLC6A15 SLC6A9 SLC6A6 SLC6A13 SLC6A2 SLC6A3 SLC6A12 TMEM64 SLC6A4 SLC6A17 OR2A1 SLC6A1 HCAR2 GPR4 OR4A5 | Amine ligand-binding receptors | Signal transduction Class A/1 (Rhodopsin-like receptors) | Signal transduction GPCR ligand binding | Signal transduction Signaling by GPCR | Signal transduction Peptide ligand-binding receptors | Signal transduction GPCR downstream signalling | Signal transduction Adrenoceptors | Signal transduction Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Dopamine receptors | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease G alpha (s) signalling events | Signal transduction G alpha (i) signalling events | Signal transduction Reuptake of GABA | Neuronal system Adrenaline signalling through Alpha-2 adrenergic receptor | Hemostasis G alpha (q) signalling events | Signal transduction Serotonin receptors | Signal transduction Orexin and neuropeptides FF and QRFP bind to their respective receptors | Signal transduction TWIK-releated acid-sensitive K+ channel (TASK) | Neuronal system Tachykinin receptors bind tachykinins | Signal transduction Histamine receptors | Signal transduction Hormone ligand-binding receptors | Signal transduction Leishmania parasite growth and survival | Disease Anti-inflammatory response favouring Leishmania parasite infection | Disease Eicosanoid ligand-binding receptors | Signal transduction | Tetrahydrofolic acid Cabazitaxel Regorafenib Pomalidomide Ifosfamide Vindesine Paliperidone Codeine Everolimus Prasterone Temazepam Naltrexone$ Gallium citrate Ga 67 Trihexyphenidyl Idarubicin Docetaxel Paclitaxel Gonadorelin Pravastatin Methylscopolamine bromide | Modafinil Mephentermine Amphetamine Imipramine Tiagabine Naltrexone$ Tolazoline Salbutamol Trihexyphenidyl Orciprenaline Drostanolone Citalopram Citric Acid Levallorphan Pseudoephedrine Ipratropium bromide Pinaverium Morphine$ Buprenorphine Codeine |
| Sepsis | bacterial sepsis fungal meningitis tinea unguium respiratory syncytial virus infectious disease | SLC6A16 SLC6A20 SLC6A7 SLC6A14 SLC6A5 SLC6A9 SLC6A15 SLC6A13 SLC6A6 TMEM64 SLC6A12 SLC6A2 SLC6A4 SLC6A3 SLC6A17 SLC6A1 YARS2 ASMTL SLC6A11 TUBE1 | RAB geranylgeranylation | Metabolism of proteins | Vindesine Pomalidomide Ifosfamide Tetrahydrofolic acid Cabazitaxel Gonadorelin Lactulose* Epirubicin Azacitidine Prednisolone*$ Idarubicin Vidarabine Cyclophosphamide Vincristine Miconazole Valaciclovir Fludarabine Prasterone Clofarabine Vinorelbine | Modafinil Tiagabine Emtricitabine*$ Lamivudine* Mephentermine Vindesine Adefovir Dipivoxil Tenofovir*$ disoproxil Amphetamine Capecitabine Tetrahydrofolic acid Decitabine$ Cidofovir* Azacitidine Vidarabine Sofosbuvir$ Famciclovir Mipomersen Pentostatin Ticagrelor*$ |
| Asthma exacerbation | allergic asthma intrinsic asthma asthma status asthmaticus | NR3C1 NR3C2 ANXA1 TSPAN13 GPR21 ADRB3 OR51B6 PRLR ITGB7 ITGB5 ITGB6 ARFGEF1 IL22RA2 OR5M11 ARFGEF2 OR5AK2 ADRB2 TMEM86B F2RL2 OR5M1 | Olfactory Signaling Pathway | Signal transduction Class A/1 (Rhodopsin-like receptors) | Signal transduction Nuclear Receptor transcription pathway | Gene expression (Transcription) Amine ligand-binding receptors | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease Peptide ligand-binding receptors | Signal transduction GPCR ligand binding | Signal transduction G alpha (s) signalling events | Signal transduction Sensory Perception | Sensory perception GPCR downstream signalling | Signal transduction TWIK-releated acid-sensitive K+ channel (TASK) | Neuronal system Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Opsins | Signal transduction Signaling by GPCR | Signal transduction Adrenoceptors | Signal transduction Adenosine P1 receptors | Signal transduction Tachykinin receptors bind tachykinins | Signal transduction | Prednisolone*$ Caffeine* Ipratropium* bromide Codeine Prasterone Temazepam Methylscopolamine bromide Fludrocortisone Pravastatin Prednisone*$ Epinephrine* Medrogestone Estriol Hydrocortisone*$ Orciprenaline Imipramine Mephentermine Flurazepam Isoprenaline Dopamine | Betamethasone* Deflazacort* Fluticasone* furoate Levonorgestrel Mometasone*$ Modafinil Salbutamol* Mephentermine Prednisolone*$ Triamcinolone* Fluorometholone Exemestane Norelgestromin Betaxolol Orciprenaline Epirubicin Imipramine Amphetamine Calcidiol Gestodene |
| Dermatologic complications/pressure ulcer | decubitus ulcer dermatographia hair disease | HOXA1 ADNP HMX3 NANOGNB ND1 SLC1A4 EVX1 SLC1A5 GPRC6A CEP57L1 ZHX1 NKX6-2 SLC25A2 S100A4 S100A5 OAZ3 LARS2 SIX4 MNX1 NAGS | tRNA Aminoacylation | Metabolism of proteins Urea cycle | Metabolism Transport of inorganic cations/anions and amino acids/oligopeptides | Transport of small molecules Mitochondrial tRNA aminoacylation | Metabolism of proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis | Developmental biology Activation of HOX genes during differentiation | Developmental biology Regulation of ornithine decarboxylase (ODC) | Metabolism Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) | Disease | Gallium citrate Ga 67 Temazepam Lurasidone Codeine Methylscopolamine bromide Apraclonidine Orphenadrine Imipramine Caffeine Paliperidone Flurazepam Trifluoperazine Prasterone Mephentermine Magnesium carbonate Amphetamine Ipratropium bromide Prednisolone$ Naltrexone$ Morphine$ | Drostanolone Citric Acid Glycine$ Vortioxetine Rimantadine Succinic acid Glecaprevir L-Lysine Sodium aurothiomalate Bisoxatin Fluciclovine Sonidegib Vigabatrin Fludeoxyglucose F-18 Methyl aminolevulinate Safinamide Mersalyl Olanzapine Ipratropium bromide Ethopropazine |
| COPD | Dressler's syndrome obstructive lung disease chronic obstructive pulmonary disease | NR4A3 KCNA10 SLC8A3 COX7A2 COX7A1 COX7A2L ELOVL7 ELOVL1 OSBPL8 ELOVL4 LXN RARRES1 OSBPL5 ITGB7 ITGB5 RARRES3 PLEKHG4 HRASLS5 NR3C2 PIGQ | Nuclear Receptor transcription pathway | Gene expression (Transcription) Olfactory Signaling Pathway | Signal transduction Sensory Perception | Sensory perception Noncanonical activation of NOTCH3 | Signal transduction PP2A-mediated dephosphorylation of key metabolic factors | Metabolism E2F mediated regulation of DNA replication | Cell cycle Acyl chain remodelling of PE | Metabolism | Prednisolone*$ Acarbose Caffeine* Codeine Ipratropium* bromide Kanamycin Prasterone Pravastatin Prednisone*$ Hydrocortisone$ Fludrocortisone Temazepam* Magnesium carbonate Methylscopolamine bromide Orciprenaline Medrogestone Mephentermine Estriol Barium sulfate Epinephrine* | Betamethasone Deflazacort Levonorgestrel Mometasone*$ Norelgestromin Prednisolone*$ Triamcinolone* Exemestane Fluticasone* furoate Fluorometholone Calcidiol Carboplatin Gestodene Gestrinone Medrogestone Dienogest Ergocalciferol Tixocortol Fludrocortisone Fluoxymesterone |
| Diabetic ketoacidosis/Hyperglycemia ketosis | type 2 diabetes mellitus diabetic retinopathy | NR4A3 NR3C2 NR3C1 ANXA1 OSBPL8 LXN RARRES1 IL22RA2 SLC8A3 ELOVL7 HRASLS5 PLEKHG4 KCNA10 PGR GPRC5A COX7A2 COX7A1 COX7A2L ELOVL1 PLA2G16 | Nuclear Receptor transcription pathway | Gene expression (Transcription) SUMOylation of intracellular receptors | Metabolism of proteins Noncanonical activation of NOTCH3 | Signal transduction PP2A-mediated dephosphorylation of key metabolic factors | Metabolism | Prednisolone$ Prasterone Trandolapril Fludrocortisone Prednisone$ Pravastatin Hydrocortisone$ Ramipril$ Enalapril Codeine Betaxolol Ifosfamide Everolimus Olmesartan Estriol Reserpine Pindolol Methyclothiazide Metoprolol Nimodipine | Betamethasone Deflazacort Fluticasone furoate Mometasone$ Triamcinolone Prednisolone$ Fluorometholone Levonorgestrel Norelgestromin Exemestane Gestodene Carboplatin Gestrinone Spironolactone$ Fludrocortisone Dienogest Beclomethasone dipropionate Norgestimate Fluoxymesterone Idebenone |
| CHF | congestive heart failure systolic heart failure | OSBPL8 OSBPL5 SHBG LXN RARRES1 VDR CHDC2 OSBPL9 KALRN PLEKHG4 HRASLS2 HRASLS5 COX7A2 COX7A2L COX7A1 CELA2B NR3C2 PLA2G16 FAM84A SLC8A1 | Nuclear Receptor transcription pathway | Gene expression (Transcription) Assembly of the pre-replicative complex | DNA replication CDT1 association with the CDC6:ORC:origin complex | DNA replication Regulation of activated PAK-2p34 by proteasome mediated degradation | Programmed cell death Regulation of ornithine decarboxylase (ODC) | Metabolism Vpu mediated degradation of CD4 | Disease Cross-presentation of soluble exogenous antigens (endosomes) | Immune system Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | Cell cycle p53-Independent G1/S DNA damage checkpoint | Cell cycle p53-Independent DNA Damage Response | Cell cycle Autodegradation of the E3 ubiquitin ligase COP1 | Cell cycle Regulation of Apoptosis | Programmed cell death Ubiquitin-dependent degradation of Cyclin D | Cell cycle FBXL7 down-regulates AURKA during mitotic entry and in early mitosis | Cell cycle SCF-beta-TrCP mediated degradation of Emi1 | Cell cycle DNA Replication Pre-Initiation | DNA replication AUF1 (hnRNP D0) binds and destabilizes mRNA | Metabolism of RNA Vif-mediated degradation of APOBEC3G | Disease Degradation of DVL | Signal transduction Degradation of AXIN | Signal transduction Negative regulation of NOTCH4 signaling | Signal transduction Regulation of RUNX3 expression and activity | Gene expression (Transcription) Stabilization of p53 | Cell cycle ROS sensing by NFE2L2 | Cellular responses to external stimuli Hh mutants are degraded by ERAD | Disease NIK-->noncanonical NF-kB signaling | Immune system Orc1 removal from chromatin | Cell cycle Degradation of GLI1 by the proteasome | Signal transduction Degradation of GLI2 by the proteasome | Signal transduction GLI3 is processed to GLI3R by the proteasome | Signal transduction SCF(Skp2)-mediated degradation of p27/p21 | Cell cycle Autodegradation of Cdh1 by Cdh1:APC/C | Cell cycle Hh mutants abrogate ligand secretion | Disease Defective CFTR causes cystic fibrosis | Disease Asymmetric localization of PCP proteins | Signal transduction Dectin-1 mediated noncanonical NF-kB signaling | Immune system Degradation of beta-catenin by the destruction complex | Signal transduction Signaling by NOTCH4 | Signal transduction APC/C:Cdc20 mediated degradation of Securin | Cell cycle p53-Dependent G1/S DNA damage checkpoint | Cell cycle p53-Dependent G1 DNA Damage Response | Cell cycle Regulation of RUNX2 expression and activity | Gene expression (Transcription) Regulation of RAS by GAPs | Signal transduction Activation of NF-kappaB in B cells | Immune system Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Cellular responses to external stimuli G1/S DNA Damage Checkpoints | Cell cycle Hedgehog ligand biogenesis | Signal transduction Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Cell cycle APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | Cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | Cell cycle Regulation of PTEN stability and activity | Signal transduction CDK-mediated phosphorylation and removal of Cdc6 | Cell cycle Regulation of HMOX1 expression and activity | Cellular responses to external stimuli Cyclin E associated events during G1/S transition | Cell cycle APC/C:Cdc20 mediated degradation of mitotic proteins | Cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | Cell cycle Cyclin A:Cdk2-associated events at S phase entry | Cell cycle Metabolism of polyamines | Metabolism Switching of origins to a post-replicative state | Cell cycle The role of GTSE1 in G2/M progression after G2 checkpoint | Cell cycle Regulation of APC/C activators between G1/S and early anaphase | Cell cycle Cellular response to hypoxia | Cellular responses to external stimuli Mitotic G1 phase and G1/S transition | Cell cycle TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | Gene expression (Transcription) Downstream signaling events of B Cell Receptor (BCR) | Immune system G1/S Transition | Cell cycle MAPK6/MAPK4 signaling | Signal transduction APC/C-mediated degradation of cell cycle proteins | Cell cycle Regulation of mitotic cell cycle | Cell cycle Hedgehog 'on' state | Signal transduction Regulation of mRNA stability by proteins that bind AU-rich elements | Metabolism of RNA DNA Replication | DNA replication UCH proteinases | Metabolism of proteins ABC transporter disorders | Disease PCP/CE pathway | Signal transduction TNFR2 non-canonical NF-kB pathway | Immune system RUNX1 regulates transcription of genes involved in differentiation of HSCs | Gene expression (Transcription) Interleukin-1 signaling | Immune system Synthesis of DNA | DNA replication | Cell cycle CDC6 association with the ORC:origin complex | DNA replication Transcriptional regulation by RUNX3 | Gene expression (Transcription) CLEC7A (Dectin-1) signaling | Immune system ABC-family proteins mediated transport | Transport of small molecules Hedgehog 'off' state | Signal transduction Downstream TCR signaling | Immune system E2F mediated regulation of DNA replication | Cell cycle Prostanoid ligand receptors | Signal transduction Transcriptional regulation by RUNX2 | Gene expression (Transcription) Host Interactions of HIV factors | Disease Inhibition of replication initiation of damaged DNA by RB1/E2F1 | Cell cycle G2/M Checkpoints | Cell cycle Cytoprotection by HMOX1 | Cellular responses to external stimuli Separation of Sister Chromatids | Cell cycle S Phase | Cell cycle Acyl chain remodelling of PS | Metabolism Noncanonical activation of NOTCH3 | Signal transduction TCR signaling | Immune system | Prasterone Trandolapril Enalapril* Ramipril*$ Codeine Nimodipine Betaxolol Olmesartan Pravastatin Reserpine Pindolol Acarbose Spirapril Prednisolone$ Metoprolol* Estriol Lovastatin Methyclothiazide Pyrazinamide Isoprenaline | Betamethasone Levonorgestrel Deflazacort Norelgestromin Mometasone$ Prednisolone$ Gestodene Fluticasone furoate Exemestane Fluorometholone Triamcinolone Gestrinone Carboplatin Fluoxymesterone Tixocortol Dienogest Nimodipine Fludrocortisone Prednisone$ Dutasteride$ |
| Respiratory failure | respiratory failure | CDIPT SESTD1 RPRD2 TREML2 YOD1 ZNF829 PDP1 SHPK IKBKAP ZNF790 ZNF44 DTX2 PELI2 RMDN2 ZNF419 ZNF485 ZNF331 UBXN4 ZWINT TTC22 | Gallium citrate Ga 67 Kanamycin Prasterone Codeine Prednisolone*$ Dicloxacillin Piperacillin*$ Naltrexone$ Magnesium carbonate Amoxicillin$ Pefloxacin Dinoprostone Trandolapril Clarithromycin$ Caffeine* Prednisone*$ Lomefloxacin Cefpodoxime Ursodeoxycholic acid Glycerin | Citric Acid Succinic acid Digoxin Betamethasone Levonorgestrel Drostanolone Prednisolone*$ Norelgestromin Calcidiol Mometasone*$ Carboplatin Exemestane Gestodene Deflazacort Alprostadil Carboprost Tromethamine Gestrinone Lactic Acid Triamcinolone* Ergocalciferol |
|
| Pulmonary embolism | pulmonary embolism and infarction | C5orf52 L3HYPDH DNPEP ACYP1 FBXO31 ACYP2 PARS2 LANCL3 TXNDC12 CCL8 ATXN3 GSTT2 GGT6 GSTT1 MBLAC1 PLGLB2 GLRX2 DCAF6 C5orf63 WDR47 | Glutathione conjugation | Metabolism G beta:gamma signalling through BTK | Signal transduction G beta:gamma signalling through CDC42 | Signal transduction G beta:gamma signalling through PLC beta | Signal transduction Prostacyclin signalling through prostacyclin receptor | Hemostasis Presynaptic function of Kainate receptors | Neuronal system ADP signalling through P2Y purinoceptor 12 | Hemostasis Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | Disease G-protein activation | Signal transduction Transport of the SLBP independent Mature mRNA | Metabolism of RNA SUMOylation of SUMOylation proteins | Metabolism of proteins Thromboxane signalling through TP receptor | Hemostasis G beta:gamma signalling through PI3Kgamma | Signal transduction ADP signalling through P2Y purinoceptor 1 | Hemostasis Transport of the SLBP Dependant Mature mRNA | Metabolism of RNA Regulation of Glucokinase by Glucokinase Regulatory Protein | Metabolism Nuclear import of Rev protein | Disease Nuclear Pore Complex (NPC) Disassembly | Cell cycle Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits | Neuronal system Activation of G protein gated Potassium channels | Neuronal system G protein gated Potassium channels | Neuronal system SUMOylation of ubiquitinylation proteins | Metabolism of proteins Transport of Mature mRNA derived from an Intron-Containing Transcript | Metabolism of RNA Adrenaline,noradrenaline inhibits insulin secretion | Metabolism Vpr-mediated nuclear import of PICs | Disease Rev-mediated nuclear export of HIV RNA | Disease Activation of kainate receptors upon glutamate binding | Neuronal system Transport of Mature mRNA Derived from an Intronless Transcript | Metabolism of RNA Interactions of Rev with host cellular proteins | Disease NS1 Mediated Effects on Host Pathways | Disease Thrombin signalling through proteinase activated receptors (PARs) | Hemostasis Glucagon-type ligand receptors | Signal transduction Transport of Mature mRNAs Derived from Intronless Transcripts | Metabolism of RNA Interactions of Vpr with host cellular proteins | Disease GRB7 events in ERBB2 signaling | Signal transduction Transport of Ribonucleoproteins into the Host Nucleus | Disease Aflatoxin activation and detoxification | Metabolism Transport of Mature Transcript to Cytoplasm | Metabolism of RNA SUMOylation of DNA replication proteins | Metabolism of proteins Inwardly rectifying K+ channels | Neuronal system SUMOylation of RNA binding proteins | Metabolism of proteins | Gadobutrol Amphetamine Nateglinide Felbamate Ipratropium bromide Phenindione Hexylresorcinol Seratrodast Mephentermine Gadoteridol Fluvoxamine$ Pantethine Piracetam Levomethadyl Acetate Digoxin Trihexyphenidyl Cilastatin Nabilone Peramivir Ethinyl* Estradiol |
|
| ARDS | adult respiratory distress syndrome | RETSAT KCNA10 SLC8A3 RDH14 RDH12 RARRES1 OSBPL8 NR4A3 DHRS7 OSBPL5 HRASLS5 ELOVL7 LXN ELOVL1 COX7A2L COX7A1 COX7A2 RDH8 ASMTL ELOVL4 | RAB geranylgeranylation | Metabolism of proteins Nuclear Receptor transcription pathway | Gene expression (Transcription) | Tetrahydrofolic acid Vindesine Ifosfamide Cabazitaxel Pomalidomide Prednisolone*$ Regorafenib Idarubicin Codeine Cyclophosphamide Paclitaxel Everolimus Gonadorelin Lactulose Prasterone Epirubicin Vincristine Pravastatin Pyrazinamide Prednisone$ | Betamethasone* Levonorgestrel Prednisolone*$ Norelgestromin Mometasone$ Deflazacort Exemestane Triamcinolone Calcidiol Gestodene Fluorometholone Gestrinone Carboplatin Fluticasone furoate Emtricitabine$ Dienogest Tixocortol Ergocalciferol Medrogestone Fluoxymesterone |