Hierarchically ranked comorbidities, comorbidity enriched MOA proteins, and the pathways for each uncharacterized COVID-19 manifestation from the SARS-CoV-2 interactome1 as input results.
| Uncharacterized manifestations | Comorbidities | Comorbidity enriched MOA proteins | Pathways | Top pathways |
|---|---|---|---|
| Neoplasms | germinoma acinar cell carcinoma skin cancer skin benign neoplasm salivary gland adenoid cystic carcinoma malignant peripheral nerve sheath tumor peripheral nerve sheath neoplasm fibrosarcoma myxoid leiomyosarcoma epithelioid leiomyosarcoma leiomyosarcoma lung oat cell carcinoma tongue squamous cell carcinoma protoplasmic astrocytoma childhood cerebral astrocytoma gemistocytic astrocytoma juvenile pilocytic astrocytoma fibrillary astrocytoma subependymal giant cell astrocytoma pilocytic astrocytoma grade III astrocytoma synovial sarcoma glioblastoma multiforme malignant mesothelioma systemic mastocytosis squamous cell carcinoma giant cell glioblastoma mesenchymoma papillary adenocarcinoma indolent systemic mastocytosis chondrosarcoma alveolar soft part sarcoma pleomorphic liposarcoma liposarcoma epithelioid sarcoma spindle cell sarcoma adenosquamous carcinoma thyroid gland carcinoma thyroid adenoma bile duct carcinoma carcinosarcoma Kaposi's sarcoma myelodysplastic/myeloproliferative neoplasm pancreatic adenocarcinoma osteosarcoma astrocytoma neurofibrosarcoma Ewing sarcoma chronic myeloid leukemia hemangiopericytoma reticulosarcoma ovarian carcinoma Leydig cell tumor sarcomatoid renal cell carcinoma chromophobe renal cell carcinoma clear cell renal cell carcinoma papillary renal cell carcinoma collecting duct carcinoma pleural cancer giant cell tumor thrombocytosis embryonal carcinoma urinary system benign neoplasm melanoma lung benign neoplasm mediastinal cancer myelodysplastic syndrome prolymphocytic leukemia acute monocytic leukemia acute T cell leukemia hepatocellular carcinoma cribriform carcinoma tubular adenocarcinoma granular cell carcinoma adenocarcinoma obsolete lymphoid leukemia acute promyelocytic leukemia liver cancer brain cancer lymphoma malignant glioma Klatskin's tumor hemangioma polycythemia vera bone marrow cancer nevoid basal cell carcinoma syndrome meningioma B- and T-cell mixed leukemia Sezary's disease sarcoma myeloid leukemia mixed glioma acute myeloid leukemia pancreatic cancer fallopian tube carcinoma mucinous adenocarcinoma isthmus cancer cerebrum cancer nervous system cancer lacrimal gland cancer female breast upper-inner quadrant cancer lacrimal duct cancer female breast nipple and areola cancer head and neck cancer Burkitt lymphoma renal cell carcinoma megakaryocytic leukemia chronic monocytic leukemia Sertoli-Leydig cell tumor sex cord-gonadal stromal tumor obsolete ymphosarcoma juvenile myelomonocytic leukemia lymphocytic leukemia urethral benign neoplasm T-cell leukemia neuroendocrine tumor mycosis fungoides inflammatory breast carcinoma myeloid sarcoma hairy cell leukemia plasma cell leukemia rectosigmoid junction cancer transverse colon cancer hepatic flexure cancer ascending colon cancer cecum cancer sigmoid colon cancer splenic flexure cancer descending colon cancer lymphoplasmacytic lymphoma macroglobulinemia cardia cancer pyloric antrum cancer pylorus cancer gastric fundus cancer small intestine cancer ileum cancer ampulla of Vater cancer retroperitoneal cancer thoracic cancer pancreatic ductal carcinoma anus cancer jejunal cancer chronic lymphocytic leukemia nasal cavity cancer broad ligament malignant neoplasm epididymis cancer malignant neoplasm of short bones of lower limb long bones of lower limb cancer female breast upper-outer quadrant cancer uterine corpus cancer occipital lobe neoplasm Waldeyer's ring cancer carotid body cancer urethra cancer spinal meninges cancer cornea cancer scrotum neoplasm renal pelvis carcinoma posterior mediastinum cancer cerebellum cancer brain stem cancer orbital cancer urinary system cancer main bronchus cancer cerebral ventricle cancer cranial nerve malignant neoplasm glottis cancer clitoris cancer mandibular cancer temporal lobe neoplasm placenta cancer female breast axillary tail cancer female breast lower-inner quadrant cancer parathyroid carcinoma sphenoidal sinus cancer parietal lobe neoplasm paraurethral gland cancer female breast lower-outer quadrant cancer female breast central part cancer ethmoid sinus cancer frontal sinus cancer maxillary sinus cancer supraglottis cancer laryngeal cartilage cancer spermatic cord cancer prepuce cancer choroid cancer labia minora cancer malignant tumor of undescended testis frontal lobe neoplasm labium majus cancer glans penis cancer bladder dome cancer ureteric orifice cancer urachus cancer urinary bladder anterior wall cancer bladder trigone cancer urinary bladder posterior wall cancer bladder neck cancer round ligament malignant neoplasm parametrium malignant neoplasm heart cancer bladder lateral wall cancer subglottis cancer multiple myeloma subacute monocytic leukemia splenic manifestation of hairy cell leukemia subacute leukemia intra-abdominal lymph node mast cell malignancy intrapelvic lymph node leukemic reticuloendotheliosis chronic erythremia essential thrombocythemia intestinal cancer Hodgkin's lymphoma, mixed cellularity Hodgkin's granuloma Hodgkin's lymphoma, lymphocytic depletion Hodgkin's lymphoma Hodgkin's lymphoma, lymphocytic-histiocytic predominance histiocytoid hemangioma intramuscular hemangioma chorioangioma acute lymphocytic leukemia acute leukemia thyroid gland cancer plasmacytoma angiosarcoma angiomyolipoma leukemia hepatoblastoma adrenal gland cancer Castleman disease autoimmune lymphoproliferative syndrome type 3 autoimmune lymphoproliferative syndrome type 2B autoimmune lymphoproliferative syndrome type 2A eye carcinoma in situ extracutaneous mastocytoma benign mastocytoma chromosome 5q deletion syndrome diffuse cutaneous mastocytosis mast cell neoplasm cutaneous mastocytosis transient myeloproliferative syndrome lymphoproliferative syndrome 2 lymphoproliferative syndrome 1 urticaria pigmentosa cancer breast cancer neurofibroma clear cell sarcoma gallbladder cancer stomach cancer rectal neoplasm cholangiocarcinoma mucoepidermoid carcinoma larynx cancer male reproductive organ cancer spinal cancer penile cancer lipoma of spermatic cord skin lipoma hemangioma of intra-abdominal structure intracranial structure hemangioma lymphangioma uterus interstitial leiomyoma subserous uterine fibroid submucous uterine fibroid cervical polyp medulloblastoma gastrointestinal system cancer thymus cancer fallopian tube cancer kidney cancer esophageal cancer tongue cancer spindle cell carcinoma carcinoma angiolipoma childhood medulloblastoma adult medulloblastoma medullomyoblastoma gastrinoma ureter cancer thymic carcinoma Meckel's diverticulum cancer intrahepatic gall duct cancer colon cancer cervical cancer peritoneum cancer histiocytoma rectum cancer gastrointestinal stromal tumor ovarian cancer gliosarcoma vulva cancer salivary gland cancer mast-cell leukemia vaginal cancer somatostatinoma olfactory neuroblastoma inverted papilloma monocytic leukemia laryngeal benign neoplasm retinal cancer lung small cell carcinoma paranasal sinus neoplasm skin melanoma nasopharynx carcinoma pyriform sinus cancer vestibule of mouth cancer submandibular gland cancer hard palate cancer lower gum cancer tonsillar fossa cancer retromolar area cancer lower lip cancer tonsil cancer sublingual gland cancer cheek mucosa cancer tonsillar pillar cancer aryepiglottic fold cancer postcricoid region cancer uvula cancer upper lip cancer oral cavity cancer gum cancer upper gum cancer soft palate cancer oropharynx cancer vallecula cancer epiglottis cancer benign mesothelioma bronchus cancer tracheal cancer lip cancer uterine adnexa cancer plexiform neurofibroma pseudomyxoma peritonei verrucous carcinoma squamous cell papilloma Langerhans-cell histiocytosis duodenum cancer pancreatic carcinoma hypopharynx cancer pancreatic endocrine carcinoma testicular cancer conjunctival cancer endocrine gland cancer neurilemmoma kidney carcinoma in situ rectum carcinoma in situ stomach carcinoma in situ liver carcinoma in situ esophagus carcinoma in situ bladder carcinoma in situ intestine carcinoma in situ larynx carcinoma in situ penis carcinoma in situ colon carcinoma in situ trachea carcinoma in situ lung carcinoma in situ breast carcinoma in situ skin carcinoma in situ lip carcinoma in situ prostate carcinoma in situ nasal cavity carcinoma in situ endometrium carcinoma in situ Richter's syndrome ureteral benign neoplasm Hodgkin's lymphoma, nodular sclerosis primary mediastinal B-cell lymphoma biliary tract cancer extramedullary plasmacytoma aggressive NK-cell leukemia adult T-cell leukemia atypical chronic myeloid leukemia squamous cell neoplasm appendix cancer intrahepatic cholangiocarcinoma liver angiosarcoma myeloproliferative neoplasm follicular adenoma microcystic adenoma papillary adenoma colorectal cancer transitional cell carcinoma parotid gland cancer uterine cancer lung cancer neuroblastoma pituitary cancer cystadenocarcinoma cervix carcinoma basal cell carcinoma female reproductive organ cancer olfactory groove meningioma transitional meningioma meningothelial meningioma fibrous meningioma psammomatous meningioma parasagittal meningioma angiomatous meningioma cerebral convexity meningioma rhabdoid meningioma microcystic meningioma secretory meningioma benign meningioma clear cell meningioma intraorbital meningioma intraventricular meningioma spinal meningioma mast-cell sarcoma colonic benign neoplasm endometrial carcinoma ganglioneuroblastoma alveolar rhabdomyosarcoma large cell carcinoma embryonal rhabdomyosarcoma serous cystadenocarcinoma Pancoast tumor astroblastoma | TUBE1 TUBAL3 ASMTL SEPT11 TUBA4A SEPT10 OR4S1 DGUOK TK2 TUBD1 NDUFA10 TUBB1 TAF6 ERI3 TREX2 ERI1 OR2T33 DCK OAS2 TUT1 | RAB geranylgeranylation | Metabolism of proteins |
| Congenital malformations, deformations and chromosomal abnormalities | tuberous sclerosis osteopetrosis Down syndrome Cowden syndrome Crouzon syndrome patent foramen ovale Klippel-Trenaunay syndrome pachyonychia congenita Peutz-Jeghers syndrome fragile X syndrome neurofibromatosis placental insufficiency pulmonary valve stenosis velocardiofacial syndrome Ehlers-Danlos syndrome aortic valve stenosis tethered spinal cord syndrome McCune Albright syndrome osteogenesis imperfecta | GMPR AMPD3 HENMT1 TRMT1 SETD8 METTL11B PRMT7 NDUFAF5 FAM86B1 PRMT5 NSUN5 SETDB1 SETMAR WHSC1L1 PRDM5 KIAA1456 METTL21C COQ5 SETD9 NSUN3 | RAB geranylgeranylation | Metabolism of proteins Folding of actin by CCT/TriC | Metabolism of proteins Kinesins | Hemostasis |
| Diseases of the digestive system | inflammatory bowel disease stomatitis oral hairy leukoplakia intestinal disease ulcerative colitis periodontitis epulis gingival disease gastroenteritis eosinophilic esophagitis periodontal disease esophagitis | RARRES3 HRASLS5 PLEKHG4 PLA2G16 RDH8 FAM84A HRASLS2 LRAT TMEM217 FAM84B ZDHHC16 BCMO1 RPE65 SLC50A1 KCNA10 EBPL ELOVL5 OSTM1 ORAI3 OSBPL5 | Nuclear Receptor transcription pathway | Gene expression (Transcription) The canonical retinoid cycle in rods (twilight vision) | Signal transduction Acyl chain remodelling of PE | Metabolism Diseases of the neuronal system | Disease Diseases associated with visual transduction | Disease Retinoid cycle disease events | Disease Acyl chain remodelling of PS | Metabolism Retinoid metabolism disease events | Disease Visual phototransduction | Signal transduction |