Hierarchically ranked comorbidities, comorbidity enriched MOA proteins, and pathways for each uncharacterized COVID-19 manifestation from the GWAS risk genes2 as input results.
| Uncharacterized manifestations | Comorbidities | Comorbidity enriched MOA proteins | Pathways | Top pathways |
|---|---|---|---|
| Mental and behavioural disorders | panic disorder depersonalization disorder agoraphobia morphine dependence substance dependence substance abuse anorexia nervosa borderline personality disorder subacute delirium pyromania dysthymic disorder anxiety disorder dyslexia obsessive-compulsive disorder hypochondriasis cognitive disorder mood disorder heroin dependence dementia Rett syndrome obsessive-compulsive personality disorder cyclothymic disorder cannabis abuse cannabis dependence intermittent explosive disorder kleptomania impulse control disorder pathological gambling eating disorder narcissistic personality disorder avoidant personality disorder schizotypal personality disorder intellectual disability hypoactive sexual desire disorder melancholia endogenous depression specific phobia cocaine dependence cocaine abuse neurotic disorder post-traumatic stress disorder mental depression social phobia phobic disorder learning disability schizoaffective disorder substance-related disorder schizophreniform disorder bulimia nervosa stereotypic movement disorder conversion disorder dissociative disorder postpartum depression sexual sadism exhibitionism psychologic vaginismus hallucinogen dependence developmental coordination disorder language disorder barbiturate abuse inhibited female orgasm inhibited male orgasm histrionic personality disorder X-linked intellectual disability-psychosis-macroorchidism syndrome communication disorder syndromic X-linked intellectual disability 94 factitious disorder premature ejaculation childhood disintegrative disease hallucinogen abuse mixed receptive-expressive language disorder fetishism gender identity disorder transvestism expressive language disorder opioid abuse psychologic dyspareunia paranoid personality disorder schizoid personality disorder multiple personality disorder dependent personality disorder sexual masochism voyeurism Gilles de la Tourette syndrome major depressive disorder nicotine dependence Asperger syndrome attention deficit hyperactivity disorder schizophrenia conduct disorder antisocial personality disorder combat disorder vascular dementia bipolar disorder generalized anxiety disorder autistic disorder somatoform disorder somatization disorder opiate dependence alcohol dependence alcohol use disorder CADASIL 2 CADASIL 1 disease of mental health | SLC6A20 SLC6A7 SLC6A16 SLC6A14 SLC6A15 SLC6A2 SLC6A3 SLC6A5 ND1 SLC6A17 SLC6A4 TMEM64 SLC6A9 HRH4 SLC6A6 SLC6A13 TAAR2 FSHR GPR39 DRD3 | Amine ligand-binding receptors | Signal transduction Olfactory Signaling Pathway | Signal transduction Class A/1 (Rhodopsin-like receptors) | Signal transduction GPCR ligand binding | Signal transduction Signaling by GPCR | Signal transduction GPCR downstream signalling | Signal transduction Sensory Perception | Sensory perception Serotonin receptors | Signal transduction ADORA2B mediated anti-inflammatory cytokines production | Disease G alpha (i) signalling events | Signal transduction G alpha (s) signalling events | Signal transduction Peptide ligand-binding receptors | Signal transduction Adrenoceptors | Signal transduction Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules Dopamine receptors | Signal transduction Eicosanoid ligand-binding receptors | Signal transduction Adenosine P1 receptors | Signal transduction Prostanoid ligand receptors | Signal transduction Adrenaline signalling through Alpha-2 adrenergic receptor | Hemostasis Reuptake of GABA | Neuronal system G alpha (q) signalling events | Signal transduction Nucleotide-like (purinergic) receptors | Signal transduction Class B/2 (Secretin family receptors) | Signal transduction Class C/3 (Metabotropic glutamate/pheromone receptors) | Signal transduction Leishmania parasite growth and survival | Disease Anti-inflammatory response favouring Leishmania parasite infection | Disease Orexin and neuropeptides FF and QRFP bind to their respective receptors | Signal transduction Histamine receptors | Signal transduction |
| Diseases of the digestive system | suppurative periapical periodontitis ileus esophageal disease burning mouth syndrome pulpitis root caries dentin sensitivity intestinal obstruction intestinal volvulus tooth disease lymphocytic colitis collagenous colitis microscopic colitis functional colonic disease dentin caries parotitis tooth agenesis amelogenesis imperfecta type 1G amelogenesis imperfecta type 1F amelogenesis imperfecta type 1H amelogenesis imperfecta hypomaturation type 2A5 amelogenesis imperfecta hypomaturation type 2A4 amelogenesis imperfecta hypomaturation type 2A3 amelogenesis imperfecta hypomaturation type 2A2 bowel dysfunction X-linked amelogenesis imperfecta hypoplastic/hypomaturation 2 amelogenesis imperfecta type 1E amelogenesis imperfecta type 2A1 amelogenesis imperfecta type 1C ulcerative stomatitis amelogenesis imperfecta type 3A amelogenesis imperfecta type 1A amelogenesis imperfecta type 4 amelogenesis imperfecta type 1B rectal prolapse lip disease alcoholic gastritis duodenitis intestinal impaction periapical periodontitis dentin dysplasia oral submucous fibrosis dental pulp calcification dentinogenesis imperfecta dermoid cyst amelogenesis imperfecta teeth hard tissue disease outlet dysfunction constipation toxic megacolon atrophic glossitis external pathological resorption median rhomboid glossitis anodontia ulcer of anus and rectum hypertrophy of tongue papillae tooth resorption sialolithiasis mucocele of salivary gland necrotizing sialometaplasia Mikulicz disease benign lymphoepithelial lesion of salivary gland hypercementosis tooth ankylosis hiatus hernia anal fistula dental abscess cascade stomach Dieulafoy lesion uvulitis acute apical periodontitis fissured tongue anal spasm megacolon chronic apical periodontitis Crohn's colitis gastroduodenal Crohn's disease pulp degeneration ileocolitis ileitis jejunoileitis diversion colitis chemical colitis anorectal stricture tongue disease gastrojejunal ulcer sialadenitis inguinal hernia stomatitis dyskinesia of esophagus atrophic gastritis gastroparesis duodenal obstruction chronic duodenal ileus dental fluorosis intussusception dental caries intestinal disease stomach disease hemorrhoid irritable bowel syndrome constipation | CX3CR1 OR51V1 CHRM3 CMKLR1 CCR2 CHRM5 CCR5 CHRM1 GPR132 OR10G7 OR5C1 OR2J2 GPR32 HRH1 OR4K5 OR4N2 OR2T27 CCR1 OR6C65 CCRL2 | Translocation of ZAP-70 to Immunological synapse | Immune system Olfactory Signaling Pathway | Signal transduction Phosphorylation of CD3 and TCR zeta chains | Immune system PD-1 signaling | Immune system MHC class II antigen presentation | Immune system Costimulation by the CD28 family | Immune system Generation of second messenger molecules | Immune system Truncations of AMER1 destabilize the destruction complex | Disease AXIN missense mutants destabilize the destruction complex | Disease APC truncation mutants have impaired AXIN binding | Disease Signaling by APC mutants | Disease Signaling by GSK3beta mutants | Disease Signaling by AXIN mutants | Disease Signaling by AMER1 mutants | Disease Signaling by CTNNB1 phospho-site mutants | Disease T41 mutants of beta-catenin aren't phosphorylated | Disease S45 mutants of beta-catenin aren't phosphorylated | Disease S33 mutants of beta-catenin aren't phosphorylated | Disease S37 mutants of beta-catenin aren't phosphorylated | Disease Downstream TCR signaling | Immune system Beta-catenin phosphorylation cascade | Signal transduction Interleukin-33 signaling | Immune system Platelet sensitization by LDL | Hemostasis TCR signaling | Immune system CTLA4 inhibitory signaling | Immune system Muscarinic acetylcholine receptors | Signal transduction Degradation of beta-catenin by the destruction complex | Signal transduction |
| Neoplasms | subependymal glioma myofibroma leiomyoma skin hemangioma endometrial adenocarcinoma histiocytoid hemangioma intramuscular hemangioma chorioangioma diabetic autonomic neuropathy pleomorphic lipoma pituitary carcinoma pituitary adenoma lipoma squamous cell papilloma prolactinoma head and neck cancer in situ carcinoma hemangioma duodenal benign neoplasm angiosarcoma myelodysplastic syndrome bone marrow cancer prostatic adenoma | COX7A2L COX7A1 COX7A2 NR4A3 SLC8A3 ELOVL7 ELOVL1 SLC8A1 ELOVL4 APH1A APH1B KCNA10 GRP NR3C2 TSPAN13 NR3C1 OSBPL5 ANXA1 OSBPL8 RARRES1 | Nuclear Receptor transcription pathway | Gene expression (Transcription) Signaling by FGFR2 IIIa TM | Disease Signaling by FGFR in disease | Disease Peptide ligand-binding receptors | Signal transduction FGFR2 mutant receptor activation | Disease Phospholipase C-mediated cascade; FGFR2 | Signal transduction SUMOylation of intracellular receptors | Metabolism of proteins FGFR2 ligand binding and activation | Signal transduction Negative regulation of FGFR2 signaling | Signal transduction Signaling by FGFR2 in disease | Disease PI3K Cascade | Signal transduction Signaling by FGFR1 amplification mutants | Disease Signaling by FGFR2 amplification mutants | Disease PI-3K cascade:FGFR2 | Signal transduction IRS-mediated signalling | Signal transduction SHC-mediated cascade:FGFR2 | Signal transduction IRS-related events triggered by IGF1R | Signal transduction FRS-mediated FGFR2 signaling | Signal transduction Noncanonical activation of NOTCH3 | Signal transduction IGF1R signaling cascade | Signal transduction Insulin receptor signalling cascade | Signal transduction Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | Signal transduction PP2A-mediated dephosphorylation of key metabolic factors | Metabolism Activated point mutants of FGFR2 | Disease Class A/1 (Rhodopsin-like receptors) | Signal transduction E2F mediated regulation of DNA replication | Cell cycle Downstream signaling of activated FGFR2 | Signal transduction Acyl chain remodelling of PE | Metabolism |