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Table S4.

Hierarchically ranked comorbidities, comorbidity enriched MOA proteins, and pathways for each uncharacterized COVID-19 manifestation from the GWAS risk genes2 as input results.

Uncharacterized manifestationsComorbiditiesComorbidity enriched MOA proteinsPathways | Top pathways
Mental and behavioural disorderspanic disorder
depersonalization disorder
agoraphobia
morphine dependence
substance dependence
substance abuse
anorexia nervosa
borderline personality disorder
subacute delirium
pyromania
dysthymic disorder
anxiety disorder
dyslexia
obsessive-compulsive disorder
hypochondriasis
cognitive disorder
mood disorder
heroin dependence
dementia
Rett syndrome
obsessive-compulsive personality disorder
cyclothymic disorder
cannabis abuse
cannabis dependence
intermittent explosive disorder
kleptomania
impulse control disorder
pathological gambling
eating disorder
narcissistic personality disorder
avoidant personality disorder
schizotypal personality disorder
intellectual disability
hypoactive sexual desire disorder
melancholia
endogenous depression
specific phobia
cocaine dependence
cocaine abuse
neurotic disorder
post-traumatic stress disorder
mental depression
social phobia
phobic disorder
learning disability
schizoaffective disorder
substance-related disorder
schizophreniform disorder
bulimia nervosa
stereotypic movement disorder
conversion disorder
dissociative disorder
postpartum depression
sexual sadism
exhibitionism
psychologic vaginismus
hallucinogen dependence
developmental coordination disorder
language disorder
barbiturate abuse
inhibited female orgasm
inhibited male orgasm
histrionic personality disorder
X-linked intellectual disability-psychosis-macroorchidism syndrome
communication disorder
syndromic X-linked intellectual disability 94
factitious disorder
premature ejaculation
childhood disintegrative disease
hallucinogen abuse
mixed receptive-expressive language disorder
fetishism
gender identity disorder
transvestism
expressive language disorder
opioid abuse
psychologic dyspareunia
paranoid personality disorder
schizoid personality disorder
multiple personality disorder
dependent personality disorder
sexual masochism
voyeurism
Gilles de la Tourette syndrome
major depressive disorder
nicotine dependence
Asperger syndrome
attention deficit hyperactivity disorder
schizophrenia
conduct disorder
antisocial personality disorder
combat disorder
vascular dementia
bipolar disorder
generalized anxiety disorder
autistic disorder
somatoform disorder
somatization disorder
opiate dependence
alcohol dependence
alcohol use disorder
CADASIL 2
CADASIL 1
disease of mental health
SLC6A20
SLC6A7
SLC6A16
SLC6A14
SLC6A15
SLC6A2
SLC6A3
SLC6A5
ND1
SLC6A17
SLC6A4
TMEM64
SLC6A9
HRH4
SLC6A6
SLC6A13
TAAR2
FSHR
GPR39
DRD3
Amine ligand-binding receptors | Signal transduction
Olfactory Signaling Pathway | Signal transduction
Class A/1 (Rhodopsin-like receptors) | Signal transduction
GPCR ligand binding | Signal transduction
Signaling by GPCR | Signal transduction
GPCR downstream signalling | Signal transduction
Sensory Perception | Sensory perception
Serotonin receptors | Signal transduction
ADORA2B mediated anti-inflammatory cytokines production | Disease
G alpha (i) signalling events | Signal transduction
G alpha (s) signalling events | Signal transduction
Peptide ligand-binding receptors | Signal transduction
Adrenoceptors | Signal transduction
Na+/Cl- dependent neurotransmitter transporters | Transport of small molecules
Dopamine receptors | Signal transduction
Eicosanoid ligand-binding receptors | Signal transduction
Adenosine P1 receptors | Signal transduction
Prostanoid ligand receptors | Signal transduction
Adrenaline signalling through Alpha-2 adrenergic receptor | Hemostasis
Reuptake of GABA | Neuronal system
G alpha (q) signalling events | Signal transduction
Nucleotide-like (purinergic) receptors | Signal transduction
Class B/2 (Secretin family receptors) | Signal transduction
Class C/3 (Metabotropic glutamate/pheromone receptors) | Signal transduction
Leishmania parasite growth and survival | Disease
Anti-inflammatory response favouring Leishmania parasite infection | Disease
Orexin and neuropeptides FF and QRFP bind to their respective receptors | Signal transduction
Histamine receptors | Signal transduction
Diseases of the digestive systemsuppurative periapical periodontitis
ileus
esophageal disease
burning mouth syndrome
pulpitis
root caries
dentin sensitivity
intestinal obstruction
intestinal volvulus
tooth disease
lymphocytic colitis
collagenous colitis
microscopic colitis
functional colonic disease
dentin caries
parotitis
tooth agenesis
amelogenesis imperfecta type 1G
amelogenesis imperfecta type 1F
amelogenesis imperfecta type 1H
amelogenesis imperfecta hypomaturation type 2A5
amelogenesis imperfecta hypomaturation type 2A4
amelogenesis imperfecta hypomaturation type 2A3
amelogenesis imperfecta hypomaturation type 2A2
bowel dysfunction
X-linked amelogenesis imperfecta hypoplastic/hypomaturation 2
amelogenesis imperfecta type 1E
amelogenesis imperfecta type 2A1
amelogenesis imperfecta type 1C
ulcerative stomatitis
amelogenesis imperfecta type 3A
amelogenesis imperfecta type 1A
amelogenesis imperfecta type 4
amelogenesis imperfecta type 1B
rectal prolapse
lip disease
alcoholic gastritis
duodenitis
intestinal impaction
periapical periodontitis
dentin dysplasia
oral submucous fibrosis
dental pulp calcification
dentinogenesis imperfecta
dermoid cyst
amelogenesis imperfecta
teeth hard tissue disease
outlet dysfunction constipation
toxic megacolon
atrophic glossitis
external pathological resorption
median rhomboid glossitis
anodontia
ulcer of anus and rectum
hypertrophy of tongue papillae
tooth resorption
sialolithiasis
mucocele of salivary gland
necrotizing sialometaplasia
Mikulicz disease
benign lymphoepithelial lesion of salivary gland
hypercementosis
tooth ankylosis
hiatus hernia
anal fistula
dental abscess
cascade stomach
Dieulafoy lesion
uvulitis
acute apical periodontitis
fissured tongue
anal spasm
megacolon
chronic apical periodontitis
Crohn's colitis
gastroduodenal Crohn's disease
pulp degeneration
ileocolitis
ileitis
jejunoileitis
diversion colitis
chemical colitis
anorectal stricture
tongue disease
gastrojejunal ulcer
sialadenitis
inguinal hernia
stomatitis
dyskinesia of esophagus
atrophic gastritis
gastroparesis
duodenal obstruction
chronic duodenal ileus
dental fluorosis
intussusception
dental caries
intestinal disease
stomach disease
hemorrhoid
irritable bowel syndrome
constipation
CX3CR1
OR51V1
CHRM3
CMKLR1
CCR2
CHRM5
CCR5
CHRM1
GPR132
OR10G7
OR5C1
OR2J2
GPR32
HRH1
OR4K5
OR4N2
OR2T27
CCR1
OR6C65
CCRL2
Translocation of ZAP-70 to Immunological synapse | Immune system
Olfactory Signaling Pathway | Signal transduction
Phosphorylation of CD3 and TCR zeta chains | Immune system
PD-1 signaling | Immune system
MHC class II antigen presentation | Immune system
Costimulation by the CD28 family | Immune system
Generation of second messenger molecules | Immune system
Truncations of AMER1 destabilize the destruction complex | Disease
AXIN missense mutants destabilize the destruction complex | Disease
APC truncation mutants have impaired AXIN binding | Disease
Signaling by APC mutants | Disease
Signaling by GSK3beta mutants | Disease
Signaling by AXIN mutants | Disease
Signaling by AMER1 mutants | Disease
Signaling by CTNNB1 phospho-site mutants | Disease
T41 mutants of beta-catenin aren't phosphorylated | Disease
S45 mutants of beta-catenin aren't phosphorylated | Disease
S33 mutants of beta-catenin aren't phosphorylated | Disease
S37 mutants of beta-catenin aren't phosphorylated | Disease
Downstream TCR signaling | Immune system
Beta-catenin phosphorylation cascade | Signal transduction
Interleukin-33 signaling | Immune system
Platelet sensitization by LDL | Hemostasis
TCR signaling | Immune system
CTLA4 inhibitory signaling | Immune system
Muscarinic acetylcholine receptors | Signal transduction
Degradation of beta-catenin by the destruction complex | Signal transduction
Neoplasmssubependymal glioma
myofibroma
leiomyoma
skin hemangioma
endometrial adenocarcinoma
histiocytoid hemangioma
intramuscular hemangioma
chorioangioma
diabetic autonomic neuropathy
pleomorphic lipoma
pituitary carcinoma
pituitary adenoma
lipoma
squamous cell papilloma
prolactinoma
head and neck cancer
in situ carcinoma
hemangioma
duodenal benign neoplasm
angiosarcoma
myelodysplastic syndrome
bone marrow cancer
prostatic adenoma
COX7A2L
COX7A1
COX7A2
NR4A3
SLC8A3
ELOVL7
ELOVL1
SLC8A1
ELOVL4
APH1A
APH1B
KCNA10
GRP
NR3C2
TSPAN13
NR3C1
OSBPL5
ANXA1
OSBPL8
RARRES1
Nuclear Receptor transcription pathway | Gene expression (Transcription)
Signaling by FGFR2 IIIa TM | Disease
Signaling by FGFR in disease | Disease
Peptide ligand-binding receptors | Signal transduction
FGFR2 mutant receptor activation | Disease
Phospholipase C-mediated cascade; FGFR2 | Signal transduction
SUMOylation of intracellular receptors | Metabolism of proteins
FGFR2 ligand binding and activation | Signal transduction
Negative regulation of FGFR2 signaling | Signal transduction
Signaling by FGFR2 in disease | Disease
PI3K Cascade | Signal transduction
Signaling by FGFR1 amplification mutants | Disease
Signaling by FGFR2 amplification mutants | Disease
PI-3K cascade:FGFR2 | Signal transduction
IRS-mediated signalling | Signal transduction
SHC-mediated cascade:FGFR2 | Signal transduction
IRS-related events triggered by IGF1R | Signal transduction
FRS-mediated FGFR2 signaling | Signal transduction
Noncanonical activation of NOTCH3 | Signal transduction
IGF1R signaling cascade | Signal transduction
Insulin receptor signalling cascade | Signal transduction
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | Signal transduction
PP2A-mediated dephosphorylation of key metabolic factors | Metabolism
Activated point mutants of FGFR2 | Disease
Class A/1 (Rhodopsin-like receptors) | Signal transduction
E2F mediated regulation of DNA replication | Cell cycle
Downstream signaling of activated FGFR2 | Signal transduction
Acyl chain remodelling of PE | Metabolism
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