Table S6.

Interactome¹ as input predicted neoplasm comorbidity enriched MOA proteins that are labeled as cancer associated in the COSMIC³⁶ database.

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Gene Symbol	Name	Combined score
EGFR	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	0.20221722589074
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.19863769406176
ERBB3	erb-b2 receptor tyrosine kinase 3	0.19863769406176
FHIT	fragile histidine triad gene	0.19610143159145
ERBB4	erb-b2 receptor tyrosine kinase 4	0.1938541695962
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.18914989334917
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.18888068954869
FES	FES proto-oncogene, tyrosine kinase	0.18887029049881
RET	ret proto-oncogene	0.18887029049881
NTRK1	neurotrophic tyrosine kinase, receptor, type 1	0.18799279786223
FLT3	fms-related tyrosine kinase 3	0.18768717244656
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.18657916888361
KDR	vascular endothelial growth factor receptor 2	0.18595018266033
FGFR1	fibroblast growth factor receptor 1	0.1859393783848
FGFR3	fibroblast growth factor receptor 3	0.18441012327791
ALK	anaplastic lymphoma kinase (Ki-1)	0.18437112066508
FLT4	fms-related tyrosine kinase 4	0.18351817529691
RHOH	ras homolog family member H	0.18234620950119
JAK3	Janus kinase 3	0.17818861900238
FGFR2	fibroblast growth factor receptor 2	0.17755744584323
DDR2	discoidin domain receptor 2	0.17487447743468
BTK	Bruton agammaglobulinemia tyrosine kinase	0.17447668503563
MAP3K13	mitogen-activated protein kinase kinase kinase 13	0.1741858648456
EPHA7	EPH receptor A7	0.17414157957245
CDK4	cyclin-dependent kinase 4	0.17393876555819
JAK1	Janus kinase 1	0.17347340095012
JAK2	Janus kinase 2	0.17347340095012
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.1716475391924
RHOA	ras homolog family member A	0.17118880451306
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.17118880451306
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.17088547957245
SETDB1	SET domain bifurcated 1	0.16993094489311
TGFBR2	transforming growth factor beta receptor II	0.16950406603325
ACVR2A	activin A receptor type 2A	0.16714855225653
EPHA3	EPH receptor A3	0.16504574014252
POLD1	DNA polymerase delta 1, catalytic subunit	0.16271889928741
ERG	v-ets erythroblastosis virus E26 oncogene like (avian)	0.16181007315915
SEPT6	septin 6	0.16023433800475
GNAS	guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1	0.16022825249406
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.15905508669834
SYK	spleen tyrosine kinase	0.15866822144893
SEPT9	septin 9	0.15859568764846
KRAS	v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog	0.15859568764846
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.15859568764846
PDGFRA	platelet-derived growth factor, alpha-receptor	0.15689808574822
FGFR4	fibroblast growth factor receptor 4	0.15654238361045
ARHGAP5	Rho GTPase activating protein 5	0.15641006555819
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.15588312897862
STK11	serine/threonine kinase 11 gene (LKB1)	0.15362153187648
TEC	tec protein tyrosine kinase	0.15347685059382

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