Interactome1 as input predicted neoplasm comorbidity enriched MOA proteins that are labeled as cancer associated in the COSMIC36 database.
| Gene Symbol | Name | Combined score |
|---|---|---|
| EGFR | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 0.20221722589074 |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.19863769406176 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | 0.19863769406176 |
| FHIT | fragile histidine triad gene | 0.19610143159145 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.1938541695962 |
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.18914989334917 |
| NTRK3 | neurotrophic tyrosine kinase, receptor, type 3 | 0.18888068954869 |
| FES | FES proto-oncogene, tyrosine kinase | 0.18887029049881 |
| RET | ret proto-oncogene | 0.18887029049881 |
| NTRK1 | neurotrophic tyrosine kinase, receptor, type 1 | 0.18799279786223 |
| FLT3 | fms-related tyrosine kinase 3 | 0.18768717244656 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.18657916888361 |
| KDR | vascular endothelial growth factor receptor 2 | 0.18595018266033 |
| FGFR1 | fibroblast growth factor receptor 1 | 0.1859393783848 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.18441012327791 |
| ALK | anaplastic lymphoma kinase (Ki-1) | 0.18437112066508 |
| FLT4 | fms-related tyrosine kinase 4 | 0.18351817529691 |
| RHOH | ras homolog family member H | 0.18234620950119 |
| JAK3 | Janus kinase 3 | 0.17818861900238 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.17755744584323 |
| DDR2 | discoidin domain receptor 2 | 0.17487447743468 |
| BTK | Bruton agammaglobulinemia tyrosine kinase | 0.17447668503563 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | 0.1741858648456 |
| EPHA7 | EPH receptor A7 | 0.17414157957245 |
| CDK4 | cyclin-dependent kinase 4 | 0.17393876555819 |
| JAK1 | Janus kinase 1 | 0.17347340095012 |
| JAK2 | Janus kinase 2 | 0.17347340095012 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | 0.1716475391924 |
| RHOA | ras homolog family member A | 0.17118880451306 |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.17118880451306 |
| BRAF | v-raf murine sarcoma viral oncogene homolog B1 | 0.17088547957245 |
| SETDB1 | SET domain bifurcated 1 | 0.16993094489311 |
| TGFBR2 | transforming growth factor beta receptor II | 0.16950406603325 |
| ACVR2A | activin A receptor type 2A | 0.16714855225653 |
| EPHA3 | EPH receptor A3 | 0.16504574014252 |
| POLD1 | DNA polymerase delta 1, catalytic subunit | 0.16271889928741 |
| ERG | v-ets erythroblastosis virus E26 oncogene like (avian) | 0.16181007315915 |
| SEPT6 | septin 6 | 0.16023433800475 |
| GNAS | guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1 | 0.16022825249406 |
| NRAS | neuroblastoma RAS viral (v-ras) oncogene homolog | 0.15905508669834 |
| SYK | spleen tyrosine kinase | 0.15866822144893 |
| SEPT9 | septin 9 | 0.15859568764846 |
| KRAS | v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog | 0.15859568764846 |
| HRAS | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 0.15859568764846 |
| PDGFRA | platelet-derived growth factor, alpha-receptor | 0.15689808574822 |
| FGFR4 | fibroblast growth factor receptor 4 | 0.15654238361045 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.15641006555819 |
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.15588312897862 |
| STK11 | serine/threonine kinase 11 gene (LKB1) | 0.15362153187648 |
| TEC | tec protein tyrosine kinase | 0.15347685059382 |
| CSF1R | colony stimulating factor 1 receptor | 0.15241307292161 |
| CDK12 | cyclin-dependent kinase 12 | 0.15226757862233 |
| CHEK2 | CHK2 checkpoint homolog (S. pombe) | 0.15203150190024 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.15190898123515 |
| ACSL6 | acyl-CoA synthetase long-chain family member 6 | 0.15081620142518 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.15023287482185 |
| ACVR1 | activin A receptor, type I | 0.14982592375297 |
| PIM1 | pim-1 oncogene | 0.14694613610451 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.14658079180523 |
| AR | Androgen Receptor | 0.14638564988124 |
| CDK6 | cyclin-dependent kinase 6 | 0.14204110475059 |
| CHD2 | chromodomain helicase DNA binding protein 2 | 0.13787985368171 |
| WRN | Werner syndrome (RECQL2) | 0.13494745090261 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.13153199173397 |
| MAP2K2 | mitogen-activated protein kinase kinase 2 | 0.13153199173397 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.13007472764846 |
| ARAF | A-Raf proto-oncogene, serine/threonine kinase | 0.1295116152019 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 0.12917194 |
| ABL1 | v-abl Abelson murine leukemia viral oncogene homolog 1 | 0.12726326912114 |
| ABL2 | c-abl oncogene 2, non-receptor tyrosine kinase | 0.1265996175772 |
| PTK6 | protein tyrosine kinase 6 | 0.1265996175772 |
| POT1 | protection of telomeres 1 | 0.12292931895487 |
| RAD17 | RAD17 checkpoint clamp loader component | 0.12207642969121 |
| BCL10 | B-cell CLL/lymphoma 10 | 0.12200010285036 |
| SEPT5 | septin 5 | 0.12157672731591 |
| ITK | IL2-inducible T-cell kinase | 0.12106702206651 |
| PMS2 | PMS2 postmeiotic segregation increased 2 (S. cerevisiae) | 0.11900840760095 |
| EZH2 | enhancer of zeste homolog 2 | 0.1188327304038 |
| DICER1 | dicer 1, ribonuclease type III | 0.11612236342043 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | 0.11591989429929 |
| ERCC3 | excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) | 0.11530477078385 |
| KIF5B | kinesin family member 5B | 0.11171278503563 |
| RAD51B | RAD51 paralog B | 0.10927628598575 |
| BUB1B | BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) | 0.10677704296912 |
| CIITA | class II, major histocompatibility complex, transactivator | 0.10424687413302 |
| MSH6 | mutS homolog 6 (E. coli) | 0.1033385871734 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.10228345059382 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 | 0.10228345059382 |
| ATIC | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase | 0.10164741306413 |