Table S9.

Statistical significance (p-value) of virus human interacting proteins’ overlap with the 723 COSMIC cancer drivers³⁶

Virus	Reference of interactome	# of interactome proteins	# of Neoplasm comorbid indications within top 100	p-value of all interactome protein overlap	p-value of overlap of top 100 proteins after LeMeDISCO prioritization
SARS-CoV-2	Ref.1	332	56	0.10	0.016
Known oncoviruses
Ad5	Ref.38	153	10	0.08	0.35
EBV	Ref.38	752	27	0.0040	1.0 X 10-13
PyV	Ref.38	314	21	3.0 X 10-4	0.04
HBV	Ref.39	146	51	1.9 X 10-24	1.3 X 10-20
HCV	Ref.40	617	72	9.2 X 10-10	1.3 X 10-22
HIV	Ref.41	4092	65	2.7 X 10-24	0.04
HPV	Ref.42	2049	89	2.3 X 10-18	1.3 X 10-20
KSHV	Ref.43	556	46	8.3 X 10-4	0.19
HTLV	Ref.44	122	6	0.10	0.55
Known non oncoviruses
Zaire-EBOLA	Ref.45	250	17	1.5 X 10-4	0.19
H1N1	Ref.46	87	3	0.66	0.75
DENV	Ref.47	222	20	8.4 X 10-6	0.19
HSV1	Ref.48	606	34	5.0 X 10-5	0.19