Georgia Tech presents great opportunities for cross-disciplinary collaboration. Under the leadership of Prof. Nick Hud, who has long been interested in the chemical origins of informational polymers such as DNA and RNA, we worked with the NSF/NASA Center for Chemical Evolution (CCE) providing the latest bioanalytical tools to support answering key prebiotic chemistry questions, such as the origin of informational polymers. We participated in collaborations to understand the origin of protopeptides, the roles of minerals in the origins of life and reanalyzing samples from the original Miller-Urey experiment to look for more complex molecules that may have been missed by the technologies available at the time. New projects in this front involve the investigation of the role of thioesters in the formation of proto peptides, and the investigation of the assembly of proto-nucleic acid molecules using structural ion mobility-mass spectrometry techniques.